UniProtKB - B4DN15 (B4DN15_HUMAN)
Protein
Submitted name:
cDNA FLJ55228, highly similar to Interstitial collagenase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 153 | UniRule annotation | 1 |
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | CalciumARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation |
Protein family/group databases
MEROPSi | M10.001 |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ55228, highly similar to Interstitial collagenaseImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- collagen trimer Source: UniProtKB-KW
- extracellular matrix Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 196 | ZnMcInterPro annotationAdd BLAST | 158 | |
Repeati | 209 – 258 | HemopexinPROSITE-ProRule annotationAdd BLAST | 50 | |
Repeati | 259 – 305 | HemopexinPROSITE-ProRule annotationAdd BLAST | 47 | |
Repeati | 308 – 356 | HemopexinPROSITE-ProRule annotationAdd BLAST | 49 | |
Repeati | 357 – 400 | HemopexinPROSITE-ProRule annotationAdd BLAST | 44 |
Sequence similaritiesi
Belongs to the peptidase M10A family.ARBA annotation
Keywords - Domaini
CollagenImported, RepeatARBA annotation, SignalARBA annotationFamily and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 1.10.101.10, 1 hit 2.110.10.10, 1 hit 3.40.390.10, 2 hits |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf IPR036366, PGBDSf |
Pfami | View protein in Pfam PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits |
i Sequence
Sequence statusi: Complete.
B4DN15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQEFFGLKVT GKPDAETLKV MKQPRCGVPD VAQFVLTEGN PRWEQTHLTY
60 70 80 90 100
RIENYTPDLP RADVDHAIEK AFQLWSNVTP LTFTKVSEGQ ADIMISFVRG
110 120 130 140 150
DHRDNSPFDG PGGNLAHAFQ PGPGIGGDAH FDEDERWTNN FREYNLHRVA
160 170 180 190 200
AHELGHSLGL SHSTDIGALM YPSYTFSGDV QLAQDDIDGI QAIYGRSQNP
210 220 230 240 250
VQPIGPQTPK ACDSKLTFDA ITTIRGEVMF FKDRFYMRTN PFYPEVELNF
260 270 280 290 300
ISVFWPQLPN GLEAAYEFAD RDEVRFFKGN KYWAVQGQNV LHGYPKDIYS
310 320 330 340 350
SFGFPRTVKH IDAALSEENT GKTYFFVANK YWRYDEYKRS MDPGYPKMIA
360 370 380 390 400
HDFPGIGHKV DAVFMKDGFF YFFHGTRQYK FDPKTKRILT LQKANSWFNC
RKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK297723 mRNA Translation: BAG60077.1 |
RefSeqi | NP_001139410.1, NM_001145938.1 |
Genome annotation databases
GeneIDi | 4312 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK297723 mRNA Translation: BAG60077.1 |
RefSeqi | NP_001139410.1, NM_001145938.1 |
3D structure databases
SMRi | B4DN15 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | M10.001 |
Proteomic databases
PeptideAtlasi | B4DN15 |
Protocols and materials databases
DNASUi | 4312 |
Genome annotation databases
GeneIDi | 4312 |
Organism-specific databases
CTDi | 4312 |
PharmGKBi | PA30867 |
Miscellaneous databases
BioGRID-ORCSi | 4312, 3 hits in 990 CRISPR screens |
GenomeRNAii | 4312 |
Gene expression databases
Genevisiblei | B4DN15, HS |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 1.10.101.10, 1 hit 2.110.10.10, 1 hit 3.40.390.10, 2 hits |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf IPR036366, PGBDSf |
Pfami | View protein in Pfam PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DN15_HUMAN | |
Accessioni | B4DN15Primary (citable) accession number: B4DN15 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |