UniProtKB - B4DKD2 (B4DKD2_HUMAN)
Protein
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 11
Gene
ADAM11
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
GO - Biological processi
- integrin-mediated signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | IntegrinImported |
Names & Taxonomyi
Protein namesi | Submitted name: Disintegrin and metalloproteinase domain-containing protein 11ImportedSubmitted name: cDNA FLJ60626, highly similar to ADAM 11 (A disintegrin and metalloproteinase domain 11)Imported |
Gene namesi | Name:ADAM11Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:189, ADAM11 |
VEuPathDBi | HostDB:ENSG00000073670.13 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 535 – 558 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 303 ↔ 323 | PROSITE-ProRule annotation | ||
Disulfide bondi | 500 ↔ 509 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | B4DKD2 |
ProteomicsDBi | 4450 |
Expressioni
Gene expression databases
Bgeei | ENSG00000073670, Expressed in right hemisphere of cerebellum and 171 other tissues |
ExpressionAtlasi | B4DKD2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 238 | Peptidase M12BInterPro annotationAdd BLAST | 200 | |
Domaini | 244 – 331 | DisintegrinInterPro annotationAdd BLAST | 88 | |
Domaini | 473 – 510 | EGF-likeInterPro annotationAdd BLAST | 38 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159790 |
HOGENOMi | CLU_012714_5_2_1 |
OrthoDBi | 162519at2759 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR013111, EGF_extracell IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF07974, EGF_2, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
B4DKD2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQGTRLPVCC ACPVGSSKPA EAEKEKVRRG HPTVHSETKY VELIVINDHQ
60 70 80 90 100
LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ
110 120 130 140 150
VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS
160 170 180 190 200
LSHGGGVNEY GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG
210 220 230 240 250
CIMEDTGFYL PRKFSRCSID EYNQFLQEGG GSCLFNKPLK LLDPPECGNG
260 270 280 290 300
FVEAGEECDC GSVQECSRAG GNCCKKCTLT HDAMCSDGLC CRRCKYEPRG
310 320 330 340 350
VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG RCYGGRCKTR
360 370 380 390 400
DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF
410 420 430 440 450
LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE
460 470 480 490 500
DGTACGPNML CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC
510 520 530 540 550
QPDWTGKDCS IHNPLPTSPP TGETERYKGP SGTNIIIGSI AGAVLVAAIV
560
LGGTGWGFKN IRRGRSGGA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO75078 | ADA11_HUMAN | Disintegrin and metalloproteinase d... | ADAM11 MDC | 769 | Annotation score: | ||
H7BY08 | H7BY08_HUMAN | Disintegrin and metalloproteinase d... | ADAM11 | 241 | Annotation score: | ||
K7EKA8 | K7EKA8_HUMAN | Disintegrin and metalloproteinase d... | ADAM11 | 517 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005180 Genomic DNA No translation available. AK296512 mRNA Translation: BAG59144.1 |
RefSeqi | NP_001305862.1, NM_001318933.1 |
Genome annotation databases
Ensembli | ENST00000535346; ENSP00000443773; ENSG00000073670 |
GeneIDi | 4185 |
UCSCi | uc060gbt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005180 Genomic DNA No translation available. AK296512 mRNA Translation: BAG59144.1 |
RefSeqi | NP_001305862.1, NM_001318933.1 |
3D structure databases
SMRi | B4DKD2 |
ModBasei | Search... |
Proteomic databases
PRIDEi | B4DKD2 |
ProteomicsDBi | 4450 |
Protocols and materials databases
Antibodypediai | 29870, 134 antibodies |
Genome annotation databases
Ensembli | ENST00000535346; ENSP00000443773; ENSG00000073670 |
GeneIDi | 4185 |
UCSCi | uc060gbt.1, human |
Organism-specific databases
CTDi | 4185 |
HGNCi | HGNC:189, ADAM11 |
OpenTargetsi | ENSG00000073670 |
VEuPathDBi | HostDB:ENSG00000073670.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159790 |
HOGENOMi | CLU_012714_5_2_1 |
OrthoDBi | 162519at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4185, 27 hits in 872 CRISPR screens |
ChiTaRSi | ADAM11, human |
GenomeRNAii | 4185 |
Gene expression databases
Bgeei | ENSG00000073670, Expressed in right hemisphere of cerebellum and 171 other tissues |
ExpressionAtlasi | B4DKD2, baseline and differential |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR013111, EGF_extracell IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF07974, EGF_2, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DKD2_HUMAN | |
Accessioni | B4DKD2Primary (citable) accession number: B4DKD2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |