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Entry version 66 (02 Jun 2021)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ54005, highly similar to Transcription elongation factor SPT5

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionElongation factorImported
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ54005, highly similar to Transcription elongation factor SPT5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B4DJK4

PeptideAtlas

More...
PeptideAtlasi
B4DJK4

PRoteomics IDEntifications database

More...
PRIDEi
B4DJK4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
4387

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 91KOWInterPro annotationAdd BLAST28
Domaini211 – 238KOWInterPro annotationAdd BLAST28
Domaini263 – 290KOWInterPro annotationAdd BLAST28
Domaini385 – 412KOWInterPro annotationAdd BLAST28
Domaini495 – 522KOWInterPro annotationAdd BLAST28
Domaini564 – 700CTDInterPro annotationAdd BLAST137
Domaini826 – 853KOWInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni462 – 492DisorderedSequence analysisAdd BLAST31
Regioni539 – 770DisorderedSequence analysisAdd BLAST232

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 23Acidic residuesSequence analysisAdd BLAST23
Compositional biasi539 – 623Polar residuesSequence analysisAdd BLAST85
Compositional biasi642 – 664Pro residuesSequence analysisAdd BLAST23
Compositional biasi665 – 739Polar residuesSequence analysisAdd BLAST75
Compositional biasi740 – 754Pro residuesSequence analysisAdd BLAST15

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06081, KOW_Spt5_1, 1 hit
cd06082, KOW_Spt5_2, 1 hit
cd06083, KOW_Spt5_3, 1 hit
cd06084, KOW_Spt5_4, 1 hit
cd06085, KOW_Spt5_5, 1 hit
cd06086, KOW_Spt5_6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005824, KOW
IPR041973, KOW_Spt5_1
IPR041975, KOW_Spt5_2
IPR041976, KOW_Spt5_3
IPR041977, KOW_Spt5_4
IPR041978, KOW_Spt5_5
IPR041980, KOW_Spt5_6
IPR014722, Rib_L2_dom2
IPR039659, SPT5
IPR024945, Spt5_C_dom
IPR017071, TF_Spt5_eukaryote
IPR008991, Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11125, PTHR11125, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00467, KOW, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036945, Spt5, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01104, CTD, 1 hit
SM00739, KOW, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104, SSF50104, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4DJK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSEDSNFS EEEDSERSSD GEEAEVDEER RSAVGNLRLG YWNQQMVPIK
60 70 80 90 100
EMTDVLKVVK EVANLKPKSW VRLKRGIYKD DIAQVDYVEP SQNTISLKMI
110 120 130 140 150
PRIDYDRIKA RMSLKDWFAK RKKFKRPPQR LFDAEKIRSL GGDVASDGDF
160 170 180 190 200
LIFEGNRYSR KGFLFKSFAM SAVITEGVKP TLSELEKFED QPEGIDLEVV
210 220 230 240 250
TESTGKEREH NFQPGDNVEV CEGELINLQG KILSVDGNKI TIMPKHEDLK
260 270 280 290 300
DMLEFPAQEL RKYFKMGDHV KVIAGRFEGD TGLIVRVEEN FVILFSDLTM
310 320 330 340 350
HELKVLPRDL QLCSETASGV DVGGQHEWGE LVQLDPQTVG VIVRLERETF
360 370 380 390 400
QVLNMYGKVV TVRHQAVTRK KDNRFAVALD SEQNNIHVKD IVKVIDGPHS
410 420 430 440 450
GREGEIRHLF RSFAFLHCKK LVENGGMFVC KTRHLVLAGG SKPRDVTNFT
460 470 480 490 500
VGGFAPMSPR ISSPMHPSAG GQRGGFGSPG GGSGGMSRGR GRRDNELIGQ
510 520 530 540 550
TVRISQGPYK GYIGVVKDAT ESTARVELHS TCQTISVDRQ RLTTVGSRRP
560 570 580 590 600
GGMTSTYGRT PMYGSQTPMY GSGSRTPMYG SQTPLQDGSR TPHYGSQTPL
610 620 630 640 650
HDGSRTPAQS GAWDPNNPNT PSRAEEEYEY AFDDEPTPSP QAYGGTPNPQ
660 670 680 690 700
TPGYPDPSSP QVNPQYNPQT PGTPAMYNTD QFSPYAAPSP QGSYQPSPSP
710 720 730 740 750
QSYHQVAPSP AGYQNTHSPA SYHPTPSPMA YQASPSPSPV GYSPMTPGAP
760 770 780 790 800
SPGGYNPHTP GSGIEQNSSD WVTTDIQVKV RDTYLDTQVV GQTGVIRSVT
810 820 830 840 850
GGMCSVYLKD SEKVVSISSE HLEPITPTKN NKVKVILGED REATGVLLSI
860 870
DGEDGIVRMD LDEQLKILNL RFLGKLLEA
Length:879
Mass (Da):96,915
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA3A7C258EFBDC9C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK296117 mRNA Translation: BAG58866.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296117 mRNA Translation: BAG58866.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiB4DJK4
PeptideAtlasiB4DJK4
PRIDEiB4DJK4
ProteomicsDBi4387

Family and domain databases

CDDicd06081, KOW_Spt5_1, 1 hit
cd06082, KOW_Spt5_2, 1 hit
cd06083, KOW_Spt5_3, 1 hit
cd06084, KOW_Spt5_4, 1 hit
cd06085, KOW_Spt5_5, 1 hit
cd06086, KOW_Spt5_6, 1 hit
Gene3Di2.30.30.30, 3 hits
InterProiView protein in InterPro
IPR005824, KOW
IPR041973, KOW_Spt5_1
IPR041975, KOW_Spt5_2
IPR041976, KOW_Spt5_3
IPR041977, KOW_Spt5_4
IPR041978, KOW_Spt5_5
IPR041980, KOW_Spt5_6
IPR014722, Rib_L2_dom2
IPR039659, SPT5
IPR024945, Spt5_C_dom
IPR017071, TF_Spt5_eukaryote
IPR008991, Translation_prot_SH3-like_sf
PANTHERiPTHR11125, PTHR11125, 1 hit
PfamiView protein in Pfam
PF00467, KOW, 1 hit
PIRSFiPIRSF036945, Spt5, 2 hits
SMARTiView protein in SMART
SM01104, CTD, 1 hit
SM00739, KOW, 6 hits
SUPFAMiSSF50104, SSF50104, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DJK4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DJK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 2, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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