UniProtKB - B4DJB4 (B4DJB4_HUMAN)
Protein
Isocitrate dehydrogenase [NAD] subunit, mitochondrial
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
- NAD binding Source: UniProtKB-UniRule
GO - Biological processi
- tricarboxylic acid cycle Source: UniProtKB-UniRule
Keywordsi
Biological process | Tricarboxylic acid cycleUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Isocitrate dehydrogenase [NAD] subunit, mitochondrialUniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Mitochondrion
- Mitochondrion UniRule annotationARBA annotation
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionUniRule annotationInteractioni
Subunit structurei
Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 308 | Iso_dhInterPro annotationAdd BLAST | 308 |
Sequence similaritiesi
Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotationARBA annotation
Keywords - Domaini
Transit peptideUniRule annotationARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004434, Isocitrate_DH_NAD IPR024084, IsoPropMal-DH-like_dom |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00175, mito_nad_idh, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
i Sequence
Sequence statusi: Complete.
B4DJB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIFDAAKAP IQWEERNVTA IQGPGGKWMI PSEAKESMDK NKMGLKGPLK
60 70 80 90 100
TPIAAGHPSM NLLLRKTFDL YANVRPCVSI EGYKTPYTDV NIVTIRENTE
110 120 130 140 150
GEYSGIEHVI VDGVVQSIKL ITEGASKRIA EFAFEYARNN HRSNVTAVHK
160 170 180 190 200
ANIMRMSDGL FLQKCREVAE SCKDIKFNEM YLDTVCLNMV QDPSQFDVLV
210 220 230 240 250
MPNLYGDILS DLCAGLIGGL GVTPSGNIGA NGVAIFESVH GTAPDIAGKD
260 270 280 290 300
MANPTALLLS AVMMLRHMGL FDHAARIEAA CFATIKDGKS LTKDLGGNAK
310
CSDFTEEICR RVKDLD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK296002 mRNA Translation: BAG58776.1 |
RefSeqi | XP_016877607.1, XM_017022118.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK296002 mRNA Translation: BAG58776.1 |
RefSeqi | XP_016877607.1, XM_017022118.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B4DJB4 |
Miscellaneous databases
BioGRID-ORCSi | 3419, 269 hits in 999 CRISPR screens |
GenomeRNAii | 3419 |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004434, Isocitrate_DH_NAD IPR024084, IsoPropMal-DH-like_dom |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00175, mito_nad_idh, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DJB4_HUMAN | |
Accessioni | B4DJB4Primary (citable) accession number: B4DJB4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |