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Entry version 78 (12 Aug 2020)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ55972, highly similar to Methyl-CpG-binding domain protein 1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri195 – 242CXXC-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri243 – 289CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri381 – 429CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
LigandMetal-bindingARBA annotation, ZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ55972, highly similar to Methyl-CpG-binding domain protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
B4DI41

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B4DI41

PRoteomics IDEntifications database

More...
PRIDEi
B4DI41

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4274

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B4DI41, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 95MBDInterPro annotationAdd BLAST69
Domaini195 – 242CXXC-typeInterPro annotationAdd BLAST48
Domaini243 – 289CXXC-typeInterPro annotationAdd BLAST47
Domaini381 – 429CXXC-typeInterPro annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 149DisorderedSequence analysisAdd BLAST44
Regioni307 – 359DisorderedSequence analysisAdd BLAST53
Regioni442 – 502DisorderedSequence analysisAdd BLAST61
Regioni571 – 624DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 121BasicSequence analysisAdd BLAST16
Compositional biasi127 – 146PolyampholyteSequence analysisAdd BLAST20
Compositional biasi336 – 359Pro-richSequence analysisAdd BLAST24
Compositional biasi475 – 489PolarSequence analysisAdd BLAST15
Compositional biasi591 – 611PolyampholyteSequence analysisAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 242CXXC-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri243 – 289CXXC-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri381 – 429CXXC-typePROSITE-ProRule annotationAdd BLAST49

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1431783at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B4DI41

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016177, DNA-bd_dom_sf
IPR001739, Methyl_CpG_DNA-bd
IPR002857, Znf_CXXC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01429, MBD, 1 hit
PF02008, zf-CXXC, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00391, MBD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54171, SSF54171, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50982, MBD, 1 hit
PS51058, ZF_CXXC, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4DI41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGFRLRTGR NAALNSDRLL LLPVASMAED WLDCPALGPG WKRREVFRKS
60 70 80 90 100
GATCGRSDTY YQSPTGDRIR SKVELTRYLG PACDLTLFDF KQGILCYPAP
110 120 130 140 150
KAHPVAVASK KRKKPSRPAK TRKRQVGPQS GEVRKEAPRD ETKADTDTAP
160 170 180 190 200
ASFPAPGCCE NCGISFSGDG TQRQRLKTLC KDCRAQRIAF NREQRMFKRV
210 220 230 240 250
GCGECAACQV TEDCGACSTC LLQLPHDVAS GLFCKCERRR CLRIVERSRG
260 270 280 290 300
CGVCRGCQTQ EDCGHCPICL RPPRPGLRRQ WKCVQRRCLR HLAHRLRRRH
310 320 330 340 350
QRCQRRTPLA VAPPTGKHAR RKGGCDSKMA ARRRPGAQPL PPPPPSQSPE
360 370 380 390 400
PTEPHPRALA PSPPAEFIYY CVDEDELQPY TNRRQNRKCG ACAACLRRMD
410 420 430 440 450
CGRCDFCCDK PKFGGSNQKR QKCRWRQCLQ FAMKRLLPSV WSESEDGAGS
460 470 480 490 500
PPPYRRRKRP SSARRHHLGP TLKPTLATRT AQPDHTQAPT KQEAGGGFVL
510 520 530 540 550
PPPGTDLVFL REGASSPVQV PGPVAASTEA LLQEAQCSGL SWVVALPQVK
560 570 580 590 600
QEKADTQDEW TPGTAVLTSP VLVPGCPSKA VDPGLPSVKQ EPPDPEEDKE
610 620 630 640 650
ENKDDSASKL APEEEAGGAG TPVITEIFSL GGTRFRDTAV WLPRSKDLKK

PGARKQ
Length:656
Mass (Da):72,398
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55C091585876E644
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK295401 mRNA Translation: BAG58353.1

NCBI Reference Sequences

More...
RefSeqi
NP_001191066.1, NM_001204137.1
NP_001191067.1, NM_001204138.1
NP_001191069.1, NM_001204140.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4152

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295401 mRNA Translation: BAG58353.1
RefSeqiNP_001191066.1, NM_001204137.1
NP_001191067.1, NM_001204138.1
NP_001191069.1, NM_001204140.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiB4DI41
MaxQBiB4DI41
PRIDEiB4DI41
ProteomicsDBi4274

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4152

Genome annotation databases

GeneIDi4152

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4152

Phylogenomic databases

OrthoDBi1431783at2759
PhylomeDBiB4DI41

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4152, 9 hits in 895 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4152

Gene expression databases

GenevisibleiB4DI41, HS

Family and domain databases

InterProiView protein in InterPro
IPR016177, DNA-bd_dom_sf
IPR001739, Methyl_CpG_DNA-bd
IPR002857, Znf_CXXC
PfamiView protein in Pfam
PF01429, MBD, 1 hit
PF02008, zf-CXXC, 3 hits
SMARTiView protein in SMART
SM00391, MBD, 1 hit
SUPFAMiSSF54171, SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS50982, MBD, 1 hit
PS51058, ZF_CXXC, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DI41_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DI41
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: August 12, 2020
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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