UniProtKB - B4DHN5 (B4DHN5_HUMAN)
Protein
Submitted name:
Syntenin-1
Gene
SDCBP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- chemical synaptic transmission Source: InterPro
- intracellular signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Syntenin-1ImportedSubmitted name: cDNA FLJ55055, moderately similar to Syntenin-1Imported |
Gene namesi | Name:SDCBPImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10662, SDCBP |
VEuPathDBi | HostDB:ENSG00000137575.11 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 198 – 220 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000137575, Expressed in substantia nigra and 249 other tissues |
ExpressionAtlasi | B4DHN5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 134 | PDZInterPro annotationAdd BLAST | 78 | |
Domaini | 139 – 214 | PDZInterPro annotationAdd BLAST | 76 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154502 |
OrthoDBi | 1035679at2759 |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR001478, PDZ IPR041489, PDZ_6 IPR036034, PDZ_sf IPR030528, SDCBP |
PANTHERi | PTHR12345:SF10, PTHR12345:SF10, 2 hits |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF17820, PDZ_6, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
B4DHN5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY
60 70 80 90 100
PELSQYMGLS LNEEEIRANV AVVSGAPLQG LVQANSPASL VGLRFGDQVL
110 120 130 140 150
QINGENCAGW SSDKAHKVLK QAFGEKITMT IRDRPFERTI TMHKDSTGHV
160 170 180 190 200
GFIFKNGKIT SIVKDSSAAR NGLLTEHNIC EINGQNVIGL KDSQIADILS
210 220 230
TSGTVVTITI MPAFIFEHII KRMAPSIMKS LMDHTIPEV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO00560 | SDCB1_HUMAN | Syntenin-1 | SDCBP MDA9, SYCL | 298 | Annotation score: | ||
G5EA09 | G5EA09_HUMAN | Syndecan binding protein (Syntenin)... | SDCBP hCG_1787561 | 318 | Annotation score: | ||
E9PBU7 | E9PBU7_HUMAN | Syntenin-1 | SDCBP | 244 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068522 Genomic DNA No translation available. AK295198 mRNA Translation: BAG58197.1 |
RefSeqi | NP_001335268.1, NM_001348339.1 |
Genome annotation databases
Ensembli | ENST00000520168; ENSP00000430730; ENSG00000137575 |
GeneIDi | 6386 |
UCSCi | uc011led.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068522 Genomic DNA No translation available. AK295198 mRNA Translation: BAG58197.1 |
RefSeqi | NP_001335268.1, NM_001348339.1 |
3D structure databases
SMRi | B4DHN5 |
ModBasei | Search... |
Proteomic databases
MaxQBi | B4DHN5 |
PRIDEi | B4DHN5 |
ProteomicsDBi | 4230 |
Protocols and materials databases
Antibodypediai | 3216, 518 antibodies |
DNASUi | 6386 |
Genome annotation databases
Ensembli | ENST00000520168; ENSP00000430730; ENSG00000137575 |
GeneIDi | 6386 |
UCSCi | uc011led.3, human |
Organism-specific databases
CTDi | 6386 |
HGNCi | HGNC:10662, SDCBP |
OpenTargetsi | ENSG00000137575 |
VEuPathDBi | HostDB:ENSG00000137575.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154502 |
OrthoDBi | 1035679at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6386, 11 hits in 996 CRISPR screens |
ChiTaRSi | SDCBP, human |
GenomeRNAii | 6386 |
Gene expression databases
Bgeei | ENSG00000137575, Expressed in substantia nigra and 249 other tissues |
ExpressionAtlasi | B4DHN5, baseline and differential |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR001478, PDZ IPR041489, PDZ_6 IPR036034, PDZ_sf IPR030528, SDCBP |
PANTHERi | PTHR12345:SF10, PTHR12345:SF10, 2 hits |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF17820, PDZ_6, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DHN5_HUMAN | |
Accessioni | B4DHN5Primary (citable) accession number: B4DHN5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |