UniProtKB - B4DH54 (B4DH54_HUMAN)
Protein
Glycerol kinase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.1.30ARBA annotation
: glycerol degradation via glycerol kinase pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- Putative glycerol kinase 5 (GK5), Glycerol kinase, Glycerol kinase, Glycerol kinase, Glycerol kinase (GK), Glycerol kinase 3 (GK3P), Glycerol kinase (GK), Glycerol kinase 2 (GK2), Glycerol kinase, Glycerol kinase (GK)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.
GO - Molecular functioni
- glycerol kinase activity Source: UniProtKB-EC
GO - Biological processi
- glycerol catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | KinaseUniRule annotationImported, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00618;UER00672 |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 67 | FGGY_NInterPro annotationAdd BLAST | 67 | |
Domaini | 76 – 267 | FGGY_CInterPro annotationAdd BLAST | 192 |
Sequence similaritiesi
Belongs to the FGGY kinase family.UniRule annotation
Phylogenomic databases
OrthoDBi | 519426at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018485, Carb_kinase_FGGY_C IPR018483, Carb_kinase_FGGY_CS IPR018484, Carb_kinase_FGGY_N |
Pfami | View protein in Pfam PF02782, FGGY_C, 1 hit PF00370, FGGY_N, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00445, FGGY_KINASES_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B4DH54-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLFNIHSLEW DKQLCEFFGI PMEILPNVRS SSEIYGLMKI SHSVKAGALE
60 70 80 90 100
GVPISGCLGD QSAALVGQMC FQIGQAKNTY GTGCFLLCNT GHKCVFSDHG
110 120 130 140 150
LLTTVAYKLG RDKPVYYALE GSVAIAGAVI RWLRDNLGII KTSEEIEKLA
160 170 180 190 200
KEVGTSYGCY FVPAFSGLYA PYWEPSARGI ICGLTQFTNK CHIAFAALEA
210 220 230 240 250
VCFQTRETLD AMNRDCGIPL SHLQVDGGMT SNKILMQLQA DILYIPVVKP
260 270 280 290 300
SMPETTALGA AMAAGAAEGV GVWSLEPEDL SAVTMERFEP QINAEESEIR
310 320 330 340 350
YSTWKKAVMK SMGWVTTQSP ESGDPSIFCS LPLGFFIVSS MVMLIGARYI
SGIP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK294938 mRNA Translation: BAG58015.1 |
RefSeqi | NP_000158.1, NM_000167.5 NP_001121599.1, NM_001128127.2 NP_001191948.1, NM_001205019.1 NP_976325.1, NM_203391.3 |
Genome annotation databases
GeneIDi | 2710 |
KEGGi | hsa:2710 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK294938 mRNA Translation: BAG58015.1 |
RefSeqi | NP_000158.1, NM_000167.5 NP_001121599.1, NM_001128127.2 NP_001191948.1, NM_001205019.1 NP_976325.1, NM_203391.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B4DH54 |
Protocols and materials databases
DNASUi | 2710 |
Genome annotation databases
GeneIDi | 2710 |
KEGGi | hsa:2710 |
Organism-specific databases
CTDi | 2710 |
Phylogenomic databases
OrthoDBi | 519426at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00618;UER00672 |
Miscellaneous databases
BioGRID-ORCSi | 2710, 5 hits in 468 CRISPR screens |
GenomeRNAii | 2710 |
Gene expression databases
Genevisiblei | B4DH54, HS |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018485, Carb_kinase_FGGY_C IPR018483, Carb_kinase_FGGY_CS IPR018484, Carb_kinase_FGGY_N |
Pfami | View protein in Pfam PF02782, FGGY_C, 1 hit PF00370, FGGY_N, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00445, FGGY_KINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DH54_HUMAN | |
Accessioni | B4DH54Primary (citable) accession number: B4DH54 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | December 2, 2020 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |