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Protein
Submitted name:

Catenin beta-1

Gene

CTNNB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Catenin beta-1Imported
Submitted name:
cDNA FLJ57878, highly similar to Beta-cateninImported
Gene namesi
Name:CTNNB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000168036.16
HGNCiHGNC:2514 CTNNB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168036

PTM / Processingi

Proteomic databases

EPDiB4DGU4
PRIDEiB4DGU4

Expressioni

Gene expression databases

BgeeiENSG00000168036 Expressed in 240 organ(s), highest expression level in adrenal tissue

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiB4DGU4, 6 interactors

Structurei

3D structure databases

SMRiB4DGU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati144 – 184ARMPROSITE-ProRule annotationAdd BLAST41
Repeati186 – 229ARMPROSITE-ProRule annotationAdd BLAST44
Repeati228 – 270ARMPROSITE-ProRule annotationAdd BLAST43
Repeati270 – 312ARMPROSITE-ProRule annotationAdd BLAST43
Repeati312 – 355ARMPROSITE-ProRule annotationAdd BLAST44
Repeati393 – 435ARMPROSITE-ProRule annotationAdd BLAST43
Repeati435 – 477ARMPROSITE-ProRule annotationAdd BLAST43
Repeati482 – 525ARMPROSITE-ProRule annotationAdd BLAST44
Repeati587 – 629ARMPROSITE-ProRule annotationAdd BLAST43

Phylogenomic databases

eggNOGiKOG4203 Eukaryota
COG0035 LUCA
GeneTreeiENSGT00730000110821
HOGENOMiHOG000230958
HOVERGENiHBG000919

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013284 Beta-catenin
PfamiView protein in Pfam
PF00514 Arm, 4 hits
PRINTSiPR01869 BCATNINFAMLY
SMARTiView protein in SMART
SM00185 ARM, 12 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.iShow all

B4DGU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELDMAMEPD RKAAVSHWQQ QSYLDSGIHS GATTTAPSLS GKGNPEEEDV
60 70 80 90 100
DTSQVLYEWE QGFSQSFTQE QVADIDGQYA MTRAQRVRAA MFPETLDEGM
110 120 130 140 150
QIPSTQFDAA HPTNVQRLAE PSQMLKHAVV NLINYQDDAE LATRAIPELT
160 170 180 190 200
KLLNDEDQVV VNKAAVMVHQ LSKKEASRHA IMRSPQMVSA IVRTMQNTND
210 220 230 240 250
VETARCTAGT LHNLSHHREG LLAIFKSGGI PALVKMLGSP VDSVLFYAIT
260 270 280 290 300
TLHNLLLHQE GAKMAVRLAG GLQKMVALLN KTNVKFLAIT TDCLQILAYG
310 320 330 340 350
NQESKLIILA SGGPQALVNI MRTYTYEKLL WTTSRVLKVL SVCSSNKPAI
360 370 380 390 400
VEAGGMQALG LHLTDPSQRL VQNCLWTLRN LSDAATKQEG MEGLLGTLVQ
410 420 430 440 450
LLGSDDINVV TCAAGILSNL TCNNYKNKMM VCQVGGIEAL VRTVLRAGDR
460 470 480 490 500
EDITEPAICA LRHLTSRHQE AEMAQNAVRL HYGLPVVVKL LHPPSHWPLI
510 520 530 540 550
KATVGLIRNL ALCPANHAPL REQGAIPRLV QLLVRAHQDT QRRTSMGGTQ
560 570 580 590 600
QQFVEGVRME EIVEGCTGAL HILARDVHNR IVIRGLNTIP LFVQLLYSPI
610 620 630 640 650
ENIQRVAAGV LCELAQDKEA AEAIEAEGAT APLTELLHSR NEGVATYAAA
660 670 680 690 700
VLFRMSEDKP QDYKKRLSVE LTSSLFRTEP MAWNETADLG LDIGAQGEPL
710 720 730 740 750
GYRQDDPSYR SFHSGGYGQD ALGMDPMMEH EMGGHHPGAD YPVDGLPDLG
760 770
HAQDLMDGLP PGDSNQLAWF DTDL
Length:774
Mass (Da):84,766
Last modified:September 23, 2008 - v1
Checksum:i785874CCE2EC6DC2
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P35222CTNB1_HUMAN
Catenin beta-1
CTNNB1 CTNNB, OK/SW-cl.35, PRO2286
781Annotation score:
E7EMJ5E7EMJ5_HUMAN
Catenin beta-1
CTNNB1
149Annotation score:
A0A2R8Y543A0A2R8Y543_HUMAN
Catenin beta-1
CTNNB1
715Annotation score:
A0A2R8YCH5A0A2R8YCH5_HUMAN
Catenin beta-1
CTNNB1
779Annotation score:
A0A2R8Y804A0A2R8Y804_HUMAN
Catenin beta-1
CTNNB1
702Annotation score:
A0A2R8Y7Z0A0A2R8Y7Z0_HUMAN
Catenin beta-1
CTNNB1
780Annotation score:
A0A2R8Y750A0A2R8Y750_HUMAN
Catenin beta-1
CTNNB1
744Annotation score:
A0A2R8Y5Z1A0A2R8Y5Z1_HUMAN
Catenin beta-1
CTNNB1
752Annotation score:
A0A2R8Y5A3A0A2R8Y5A3_HUMAN
Catenin beta-1
CTNNB1
783Annotation score:
A0A2R8Y5C3A0A2R8Y5C3_HUMAN
Catenin beta-1
CTNNB1
737Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104307 Genomic DNA No translation available.
AK294778 mRNA Translation: BAG57905.1
RefSeqiNP_001317658.1, NM_001330729.1
XP_006713046.1, XM_006712983.1
XP_006713047.1, XM_006712984.1
UniGeneiHs.476018
Hs.712929

Genome annotation databases

EnsembliENST00000453024; ENSP00000411226; ENSG00000168036
ENST00000642836; ENSP00000496295; ENSG00000168036
ENST00000644524; ENSP00000494780; ENSG00000168036
ENST00000644678; ENSP00000495794; ENSG00000168036
ENST00000645493; ENSP00000494467; ENSG00000168036
ENST00000645900; ENSP00000495286; ENSG00000168036
ENST00000646116; ENSP00000495426; ENSG00000168036
ENST00000646174; ENSP00000495161; ENSG00000168036
ENST00000646381; ENSP00000496067; ENSG00000168036
GeneIDi1499
UCSCiuc011azf.2 human

Similar proteinsi

Entry informationi

Entry nameiB4DGU4_HUMAN
AccessioniPrimary (citable) accession number: B4DGU4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 12, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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