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1 to 25 of 158  Show
  1. 1
    "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 7178 other entries.

  2. 2
    "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Tissue: Amygdala.
    Source: UniProtKB/TrEMBL (unreviewed).
  3. 3
    "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 5612 other entries.

  4. 4
    Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Source: UniProtKB/TrEMBL (unreviewed).
  5. 5
    "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 11670 other entries.

  6. 6
    "Mutations of the human polycystic kidney disease 2 (PKD2) gene."
    Deltas C.C.
    Hum. Mutat. 18:13-24(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: review of reported mutationsImported.
    Source: GeneRIF:5311.

    This publication is mapped to 6 other entries.

  7. 7
    Category: Function.
    Annotation: functions as a calcium-activated intracellular calcium release channel in vivo and polycystic kidney disease results from the loss of a regulated intracellular calcium release signalling mechanismImported.
    Source: GeneRIF:5311.

    This publication is cited by 1 and mapped to 5 other entries.

  8. 8
    "Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development."
    Chauvet V., Qian F., Boute N., Cai Y., Phakdeekitacharoen B., Onuchic L.F., Attie-Bitach T., Guicharnaud L., Devuyst O., Germino G.G., Gubler M.C.
    Am. J. Pathol. 160:973-983(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: found profound differences in the spatiotemporal expression of PKD1 and PKD2 during nephrogenesis PKD2 being expressed earlier and more diffusely than PKD1Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 15 other entries.

  9. 9
    "Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex."
    Newby L.J., Streets A.J., Zhao Y., Harris P.C., Ward C.J., Ong A.C.
    J. Biol. Chem. 277:20763-20773(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location, Interaction.
    Annotation: identification characterization and localization of a complex with polycystin 1Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 28 other entries.

  10. 10
    "Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity."
    Gonzalez-Perrett S., Batelli M., Kim K., Essafi M., Timpanaro G., Moltabetti N., Reisin I.L., Arnaout M.A., Cantiello H.F.
    J. Biol. Chem. 277:24959-24966(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: role in mediating cation channel activityImported.
    Source: GeneRIF:5311.

    This publication is mapped to 6 other entries.

  11. 11
    "Polycystin-2 interacts with troponin I, an angiogenesis inhibitor."
    Li Q., Shen P.Y., Wu G., Chen X.Z.
    Biochemistry 42:450-457(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: Several independent lines of evidence reveal that the carboxyl terminal domain (D682-V968) of polycystin 2 interacts with cardiac and skeletal isoforms of troponin I.Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 17 other entries.

  12. 12
    "Polycystin-2 associates with tropomyosin-1, an actin microfilament component."
    Li Q., Dai Y., Guo L., Liu Y., Hao C., Wu G., Basora N., Michalak M., Chen X.Z.
    J. Mol. Biol. 325:949-962(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: identified and demonstrated that the intracellular C terminus of PC2 associates with a core regulatory protein of the actin cytoskeleton system tropomyosin-1Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 27 other entries.

  13. 13
    Category: Pathology & Biotech, Sequences.
    Annotation: that the location of PKD2 mutations did not influence the age of onset of ESRD however patients with splice site mutations appeared to have milder renal disease compared with patients with other mutation typesImported.
    Source: GeneRIF:5311.

    This publication is mapped to 5 other entries.

  14. 14
    "Role of polycystins in renal tubulogenesis."
    Boletta A., Germino G.G.
    Trends Cell Biol. 13:484-492(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: REVIEW: Role in renal tubulogenesisImported.
    Source: GeneRIF:5311.

    This publication is mapped to 28 other entries.

  15. 15
    "PKD2 mutations in a Czech population with autosomal dominant polycystic kidney disease."
    Stekrova J., Reiterova J., Merta M., Damborsky J., Zidovska J., Kebrdlova V., Kohoutova M.
    Nephrol. Dial. Transplant. 19:1116-1122(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: An at-least weak hot spot in exon 1 of the PKD2 gene was found in autosomal dominant polycystic kidney disease patients in the Czech Republic; Observational study of genotype prevalence. (HuGE Navigator)Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 5 other entries.

  16. 16
    "Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells."
    Aguiari G., Banzi M., Gessi S., Cai Y., Zeggio E., Manzati E., Piva R., Lambertini E., Ferrari L., Peters D.J., Lanza F., Harris P.C., Borea P.A., Somlo S., Del Senno L.
    FASEB J. 18:884-886(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: In PKD2- B-lymphoblastoid cells transfection of a PKD2 full-length cDNA causes an increase in intracellular Ca2+ levels & cell proliferation. PC2 functions in a Ca2+ signaling context which in turn modulates gene expression.Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 15 other entries.

  17. 17
    "PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles."
    Rundle D.R., Gorbsky G., Tsiokas L.
    J. Biol. Chem. 279:29728-29739(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: Results show that mDia1 and PKD2 interact in native and in transfected cells and binding is mediated by the cytoplasmic C terminus of PKD2 binding to the mDia1 N terminus.Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 28 other entries.

  18. 18
    "Regulation of calcium signaling by polycystin-2."
    Cantiello H.F.
    Am. J. Physiol. Renal Physiol. 286:F1012-29(2004) [PubMed] [Europe PMC] [Abstract]
    Annotation: PC2 channel function may be essential in renal cell function and kidney development--REVIEWImported.
    Source: GeneRIF:5311.

    This publication is mapped to 6 other entries.

  19. 19
    "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2."
    Hidaka S., Koenecke V., Osten L., Witzgall R.
    J. Biol. Chem. 279:35009-35016(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: the intracellular location of polycystin-2 is regulated by PIGEA-14Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 8 other entries.

  20. 20
    "[Gene diagnosis of autosomal dominant polycystic kidney disease type 2 using microsatellite DNA tightly linked to polycystic kidney disease gene 2]."
    Zhang W.L., Zhang D.Y., Wu Y.M., Sun T.M., Mei C.L.
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:325-328(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Data show that gene diagnosis can be done for PKD2 mutation carriers prior to cytogenesis.Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 6 other entries.

  21. 21
    "Polycystic disease of the liver."
    Everson G.T., Taylor M.R., Doctor R.B.
    Hepatology 40:774-782(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: The PKD2 gene product polycystin-2 is an integral membrane protein with molecular characteristics of a calcium-permeant cation channel.Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 15 other entries.

  22. 22
    "Mutations of the PKD2 gene in Taiwanese patients with autosomal dominant polycystic kidney disease."
    Chang M.Y., Fang J.T., Huang C.C., Wu I.W., Wu Chou Y.H.
    Ren Fail 27:95-100(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Observational study of genotype prevalence. (HuGE Navigator)Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 6 other entries.

  23. 23
    "Molecular pathogenesis of ADPKD: the polycystin complex gets complex."
    Ong A.C., Harris P.C.
    Kidney Int. 67:1234-1247(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Structure and function of this gene shows how mutation at this locus results in the spectrum of changes seen in autosomal-dominant polycystic kidney disease. (review)Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 15 other entries.

  24. 24
    "Effect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblast."
    Montalbetti N., Li Q., Gonzalez-Perrett S., Semprine J., Chen X.Z., Cantiello H.F.
    Pflugers Arch. 451:294-303(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: Our findings indicate that physical forces exerted on cells regulate polycystin-2 channel activity by a sensory mechanism involving the actin cytoskeleton.Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 6 other entries.

  25. 25
    "A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia."
    Roitbak T., Surviladze Z., Tikkanen R., Wandinger-Ness A.
    Biochem. J. 392:29-38(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: The polycystin multiprotein complex is embedded in a cholesterol-containing signalling microdomain specified by flotillin-2 which is distinct from classical light-buoyant-density detergent-resistant domains.Imported.
    Source: GeneRIF:5311.

    This publication is mapped to 15 other entries.

1 to 25 of 158  Show
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