Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 28 (31 Jul 2019)
Sequence version 1 (23 Sep 2008)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Nucleolar protein 6

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein 6UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B4DF80

PRoteomics IDEntifications database

More...
PRIDEi
B4DF80

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 258NrapInterPro annotationAdd BLAST133
Domaini264 – 410Nrap_D2InterPro annotationAdd BLAST147
Domaini416 – 576Nrap_D3InterPro annotationAdd BLAST161
Domaini592 – 794Nrap_D4InterPro annotationAdd BLAST203
Domaini796 – 951Nrap_D5InterPro annotationAdd BLAST156
Domaini953 – 1085Nrap_D6InterPro annotationAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 40PolyampholyteSequence analysisAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRAP family.UniRule annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005554 NOL6/Upt22
IPR035082 Nrap_D1
IPR035367 Nrap_D2
IPR035368 Nrap_D3
IPR035369 Nrap_D4
IPR035370 Nrap_D5
IPR035371 Nrap_D6

The PANTHER Classification System

More...
PANTHERi
PTHR17972 PTHR17972, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03813 Nrap, 1 hit
PF17403 Nrap_D2, 1 hit
PF17404 Nrap_D3, 1 hit
PF17405 Nrap_D4, 1 hit
PF17406 Nrap_D5, 1 hit
PF17407 Nrap_D6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4DF80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPAPAGEQL RGATGEPEVM EPALEGTGKE GKKASSRKRT LAEPPAKGLL
60 70 80 90 100
QPVKLSRAEL YKEPTNEELN RLRETEILFH SSLLRLQVEE LLKEVRLSEK
110 120 130 140 150
KKDRIDAFLR EVNQRVVRVP SVPETEEILQ DKDGLNQRYF RKRALYLAHL
160 170 180 190 200
AHHLAQDPLF GSVCFSYTNG CHLKPSLLLR PRGKDERLVT VRLHPCPPPD
210 220 230 240 250
FFRPCRLLPT KNNVRSAWYR GQSPAGDGSP EPPTPRYNTW VLQDTVLESH
260 270 280 290 300
LQLLSTILSS AQGLKDGVAL LKVWLRQREL DKGQGGFTGF LVSMLVVFLV
310 320 330 340 350
STRKIHTTMS GYQVLRSVLQ FLATTDLTVN GISLCLSSDP SLPALADFHQ
360 370 380 390 400
AFSVVFLDSS GHLNLCADVT ASTYHQGWSL LWLQVQHEAR LSMMLLDSRA
410 420 430 440 450
DDGFHLLLMT PKPMIRAFDH VLHLRPLSRL QAACHRLKLW PELQDNGGDY
460 470 480 490 500
VSAALGPLTT LLEQGLGARL NLLAHSRPPV PEWDISQDPP KHKDSGTLTL
510 520 530 540 550
GLLLRPEGLT SVLELGPEAD QPEAAKFRQF WGSRSELRRF QDGAIREAVV
560 570 580 590 600
WEAASMSQKR LIPHQVVTHL LALHADIPET CVHYVGGPLD ALIQGLKETS
610 620 630 640 650
STGEEALVAA VRCYDDLSRL LWGLEGLPLT VSAVQGAHPV LRYTEVFPPT
660 670 680 690 700
PVRPAFSFYE TLRERSSLLP RLDKPCPAYV EPMTVVCHLE GSGQWPQDAE
710 720 730 740 750
AVQRVRAAFQ LRLAELLTQQ HGLQCRATAT HTDVLKDGFV FRIRVAYQRE
760 770 780 790 800
PQILKEVQSP EGMISLRDTA ASLRLERDTR QLPLLTSALH GLQQQHPAFS
810 820 830 840 850
GVARLAKRWV RAQLLGEGFA DESLDLVAAA LFLHPEPFTP PSSPQVGFLR
860 870 880 890 900
FLFLVSTFDW KNNPLFVNLN NELTVEEQVE IRSGFLAARA QLPVMVIVTP
910 920 930 940 950
QDRKNSVWTQ DGPSAQILQQ LVVLAAEALP MLEKQLMDPR GPGDIRTVFR
960 970 980 990 1000
PPLDIYDVLI RLSPRHIPRH RQAVDSPAAS FCRGLLSQPG PSSLMLVLGY
1010 1020 1030 1040 1050
DPPQLYLTQL REAFGDLALF FYDQHGGEVI GVLWKPTSFQ PQPFKASSTK
1060 1070 1080 1090
GRMVMSRGGE LVMVPNVEAI LEDFAVLGEG LVQTVEARSE RWTV
Length:1,094
Mass (Da):122,049
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B2A3838A6F9DBDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK293969 mRNA Translation: BAG57341.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293969 mRNA Translation: BAG57341.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB4DF80
PRIDEiB4DF80

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR005554 NOL6/Upt22
IPR035082 Nrap_D1
IPR035367 Nrap_D2
IPR035368 Nrap_D3
IPR035369 Nrap_D4
IPR035370 Nrap_D5
IPR035371 Nrap_D6
PANTHERiPTHR17972 PTHR17972, 2 hits
PfamiView protein in Pfam
PF03813 Nrap, 1 hit
PF17403 Nrap_D2, 1 hit
PF17404 Nrap_D3, 1 hit
PF17405 Nrap_D4, 1 hit
PF17406 Nrap_D5, 1 hit
PF17407 Nrap_D6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DF80_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DF80
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 31, 2019
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again