UniProtKB - B4DF51 (B4DF51_HUMAN)
Protein
Submitted name:
Myeloid cell surface antigen CD33
Gene
CD33
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Myeloid cell surface antigen CD33ImportedSubmitted name: cDNA FLJ50122, highly similar to Myeloid cell surface antigen CD33Imported |
Gene namesi | Name:CD33Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1659, CD33 |
VEuPathDBi | HostDB:ENSG00000105383.14 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 134 – 155 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5014085091 | 18 – 212 | Sequence analysisAdd BLAST | 195 |
Proteomic databases
PRIDEi | B4DF51 |
ProteomicsDBi | 4007 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105383, Expressed in monocyte and 139 other tissues |
ExpressionAtlasi | B4DF51, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 101 | Ig-likeInterPro annotationAdd BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 164 – 188 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 169 – 183 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00990000203561 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B4DF51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLLLLLPLL WADLTHRPKI LIPGTLEPGH SKNLTCSVSW ACEQGTPPIF
60 70 80 90 100
SWLSAAPTSL GPRTTHSSVL IITPRPQDHG TNLTCQVKFA GAGVTTERTI
110 120 130 140 150
QLNVTYVPQN PTTGIFPGDG SGKQETRAGV VHGAIGGAGV TALLALCLCL
160 170 180 190 200
IFFIVKTHRR KAARTAVGRN DTHPTTGSAS PVSDGASWHP VCPADTSSQC
210
GPPSCPIQHF QN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP20138 | CD33_HUMAN | Myeloid cell surface antigen CD33 | CD33 SIGLEC3 | 364 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC063977 Genomic DNA No translation available. KF511276 Genomic DNA No translation available. AK293934 mRNA Translation: BAG57312.1 |
Genome annotation databases
Ensembli | ENST00000436584; ENSP00000403331; ENSG00000105383 |
UCSCi | uc061bwj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC063977 Genomic DNA No translation available. KF511276 Genomic DNA No translation available. AK293934 mRNA Translation: BAG57312.1 |
3D structure databases
SMRi | B4DF51 |
ModBasei | Search... |
Proteomic databases
PRIDEi | B4DF51 |
ProteomicsDBi | 4007 |
Protocols and materials databases
Antibodypediai | 4419, 2480 antibodies |
Genome annotation databases
Ensembli | ENST00000436584; ENSP00000403331; ENSG00000105383 |
UCSCi | uc061bwj.1, human |
Organism-specific databases
HGNCi | HGNC:1659, CD33 |
OpenTargetsi | ENSG00000105383 |
VEuPathDBi | HostDB:ENSG00000105383.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00990000203561 |
Miscellaneous databases
ChiTaRSi | CD33, human |
Gene expression databases
Bgeei | ENSG00000105383, Expressed in monocyte and 139 other tissues |
ExpressionAtlasi | B4DF51, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF00047, ig, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B4DF51_HUMAN | |
Accessioni | B4DF51Primary (citable) accession number: B4DF51 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |