Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Translation initiation factor IF-2

Gene

infB

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi453 – 460GTPUniRule annotation8
Nucleotide bindingi499 – 503GTPUniRule annotation5
Nucleotide bindingi553 – 556GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS543734:G1GID-1829-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:LCABL_17860
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000937961 – 943Translation initiation factor IF-2Add BLAST943

Proteomic databases

PRIDEiB3WER5

Structurei

3D structure databases

ProteinModelPortaliB3WER5
SMRiB3WER5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini444 – 613tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni453 – 460G1By similarity8
Regioni478 – 482G2By similarity5
Regioni499 – 502G3By similarity4
Regioni553 – 556G4By similarity4
Regioni589 – 591G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU Bacteria
COG0532 LUCA
HOGENOMiHOG000076906
KOiK02519
OMAiDNRTGGY

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B IF_2_B, 1 hit
InterProiView protein in InterPro
IPR006847 IF2_N
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
PF04760 IF2_N, 2 hits
SUPFAMiSSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00487 IF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

B3WER5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKRVYEFA KEMHVDNKDV IDIAKNLGIE VKNHMSSIDQ DQEAKIKGML
60 70 80 90 100
SKQSAGKAPS SQAAKTPAKA AKTSSAAHKE AAKKPVAASA KSNDHADVAE
110 120 130 140 150
HSQKNAKPAA KQENKPARSN KTSDGKIILS KSTILRPRST QTAHTNTNHN
160 170 180 190 200
RGGNTASANN TANGRNSNRS NNNNNNRSAN NANRSGNNNR SNERNRNDRN
210 220 230 240 250
RRFDNQRVTG PMPRAGRPTA ANGNPRPVAG NGGKFVKPAS ERQQPKRQEA
260 270 280 290 300
VKPANAASKR SEQPRTERPR TEQPAATTNQ RFTKPAPVPA AAAPKPASAG
310 320 330 340 350
SQDNRNSRRG GGNSNFGRSN SYGNRNGFNR NNRRNKKNKR RQQSAPKKEM
360 370 380 390 400
PQRKERPLPE TLIYEVGMNA QDLGKILHRE PAELIKKLFM LGVMVNQNQS
410 420 430 440 450
LDKDTIELLA TDYGIDAQEK VHEDISDLDK VFEEENKNQD NLQPRPPVVT
460 470 480 490 500
IMGHVDHGKT TLLDKLRHTH VTEGEAGGIT QHIGAYQVKL RDRLITFLDT
510 520 530 540 550
PGHAAFTNMR ARGADITDIV VLVVAADDGV MPQTIEAIHH AQAAKAPIIV
560 570 580 590 600
AVNKIDKPGA NPDHVMEQLT EYGLIPEDWG GDTIFVKISA KFGKNIDELL
610 620 630 640 650
EMILLEADVL ELKANPDQKA VGTVIEARLD KGKGPVATVL VQQGTLHTGD
660 670 680 690 700
PIVVGNTFGR VRAMTNDHGR RVKDALPSMP VEITGINDVP QSADKFVVFA
710 720 730 740 750
DERTARAAGE ERAKRAQEEE RKNTNHVTLD NLFETMKEGQ LKEVDVIIKA
760 770 780 790 800
DVQGSVEALA GSLEKIEVKG VRVNIIHQAV GAINESDVTL AAASNAIIIG
810 820 830 840 850
FNVRPTALAK AQAEQDDVDI RLHSVIYKAI EEVEAAMKGM LEPTYEEKVI
860 870 880 890 900
GTVTVRETIP VSKVGTVVGG YVDSGYITRD AGVRLVRDGI VKYEGKLGSL
910 920 930 940
RRFKDDVKEV RQGFELGLTI ENYNDIKVDD QIEAFTMEQV PVK
Length:943
Mass (Da):103,151
Last modified:September 2, 2008 - v1
Checksum:i01B5958EAC6C5C54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA Translation: CAQ66866.1
RefSeqiWP_012491636.1, NC_010999.1

Genome annotation databases

EnsemblBacteriaiCAQ66866; CAQ66866; LCABL_17860
KEGGilcb:LCABL_17860

Entry informationi

Entry nameiIF2_LACCB
AccessioniPrimary (citable) accession number: B3WER5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health