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Protein

UvrABC system protein C

Gene

uvrC

Organism
Lactobacillus casei (strain BL23)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:LCABL_15670
OrganismiLactobacillus casei (strain BL23)
Taxonomic identifieri543734 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000994951 – 602UvrABC system protein CAdd BLAST602

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Structurei

3D structure databases

SMRiB3WE47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 92GIY-YIGUniRule annotationAdd BLAST78
Domaini197 – 232UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII Bacteria
COG0322 LUCA
HOGENOMiHOG000279960
KOiK03703
OMAiLFPIRQC

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

B3WE47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAHIEHKL SLLPDLPGSY QMKDINGKII YVGKAKNLKN RVRSYFKSSH
60 70 80 90 100
DGKVAAMVSQ VADFDFIVTS TDKEAFLLEI TLIQKYQPYY NIKLKKGTGY
110 120 130 140 150
PYIKITHERD PKIEITGTIR KDGGYYFGPY PNVYAAQETM HFIQKVYPLR
160 170 180 190 200
RCNGYQGRPC LYYHMGQCLG ACFRTVPEKE YTDQIERIKR FLNGNVGKAK
210 220 230 240 250
ASLTAKMERA AKNLQFERAA EIRDQLHYIE QTVEKQKIIS HDNTTRDLFN
260 270 280 290 300
FYMDKGWISI QVFFIRQARL MKRESRLFPV VNTAKEEFES FILQFYSRKN
310 320 330 340 350
NVKPREVLVP AALDNKVLAD ILEIPVRTPQ RGEKRDLMAL AAKNSQIKLE
360 370 380 390 400
DKFRLMELDN RTTIGAMKEL MAALNLPMGH VAEAFDHSHI QGADPVSAMV
410 420 430 440 450
QFVDGQPAKN NYRKYKLDAD KTHNGADEAA NTREVIRRRY TRLLKERAPL
460 470 480 490 500
PDLILMDGGE IEMNAAKDVL ENELNLDIPV AGMVKNNKHK TAALLFGNAD
510 520 530 540 550
QLINLDPKSQ GFYLLERIQD EVHRFAITFH RQLHAKNSLA SRLEGIKGVG
560 570 580 590 600
PKTRLKLLRK FKTINKIKEA PLEDIQELGI SKKVAQALKL SLTAEPTPAR

RV
Length:602
Mass (Da):68,874
Last modified:September 2, 2008 - v1
Checksum:i73F3BF1D7BCDD19D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM177140 Genomic DNA Translation: CAQ66648.1
RefSeqiWP_012491562.1, NC_010999.1

Genome annotation databases

EnsemblBacteriaiCAQ66648; CAQ66648; LCABL_15670
KEGGilcb:LCABL_15670

Similar proteinsi

Entry informationi

Entry nameiUVRC_LACCB
AccessioniPrimary (citable) accession number: B3WE47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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