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Protein
Submitted name:

Cation-chloride cotransporter-like protein

Gene
N/A
Organism
Lotus tenuis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cation-chloride cotransporter-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLotus tenuisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri347996 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladeNPAAA cladeHologaleginarobinioid cladeLoteaeLotus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei142 – 163HelicalSequence analysisAdd BLAST22
Transmembranei175 – 200HelicalSequence analysisAdd BLAST26
Transmembranei221 – 242HelicalSequence analysisAdd BLAST22
Transmembranei282 – 301HelicalSequence analysisAdd BLAST20
Transmembranei308 – 329HelicalSequence analysisAdd BLAST22
Transmembranei403 – 426HelicalSequence analysisAdd BLAST24
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Transmembranei525 – 544HelicalSequence analysisAdd BLAST20
Transmembranei565 – 594HelicalSequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 623AA_permeaseInterPro annotationAdd BLAST477
Domaini657 – 778SLC12InterPro annotationAdd BLAST122
Domaini789 – 987SLC12InterPro annotationAdd BLAST199

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C
IPR004842 SLC12A_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit
PF03522 SLC12, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00930 2a30, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3VBE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGADDDVEAA GADGGFRSPI GRKYRPVLAN DRAVLEMSSI DPGSSSSSSS
60 70 80 90 100
VIPDPPPNLR KINVGSSSSA SSDAKEGKSS HPPQPNGPQQ DSKLELFGFD
110 120 130 140 150
SLVNILGLKS MTGEQVAAPS SPRDGEDITI PAGLPKPPAL RLGTMMGVFI
160 170 180 190 200
PCLQSILGII YYIRFSWIVG MGGIGGTLLL VALCGTCTFL TAISLSAIAT
210 220 230 240 250
NGAMKGGGPY YLIGRALGPE VGVSIGLCFF LGNAVAGALY VLGAVETFLK
260 270 280 290 300
AVPAAGIFRE TITQVNGTTI AQPIESPSSH DLQIYGIVVT IVLCFIVFGG
310 320 330 340 350
VKMINRVAPA FLIPVLFSLI CIYLGILLAR EDHPAEGITG LSLETLKDNW
360 370 380 390 400
GSEYQKTNDA GIPEPDGSVS WNFNALVGLF FPAVTGIMAG SNRSSSLKDT
410 420 430 440 450
QRSIPLGTLA ATLVTTFMYL VSVIMFGALA TREKLLTDRL LTATVAWPFP
460 470 480 490 500
SLIKIGIILS TMGAALQSLT GAPRLLAAIA NDDILPILKY FKVADGSEPH
510 520 530 540 550
VATLFTAFLC SGCVVIGNLD LITPTVTMFF LLCYAGVNLS CFLLDLLDAP
560 570 580 590 600
SWRPRWKFHH WSLSLVGALL CIVIMFLISW SFTVVSLALA SLIYKYVSLK
610 620 630 640 650
GKAGDWGDGF KSAYFQLALR SLRSLGASQV HPKNWYPIPL VFCRPWGRLP
660 670 680 690 700
ENVPCHPKLA DFANCMKKKG RGMSIFVSIL DGDYHECAED AKAACKQLST
710 720 730 740 750
YIDYKNCEGV AEIVVAPNMS EGFRGIVQTM GLGNLKPNIV VMRYPEIWRR
760 770 780 790 800
ENLTEIPATF VGIINDCIVA NKAVVIMKGL DEWPNEYQKQ YGTIDLYWIV
810 820 830 840 850
RDGGLMLLLS QLLLTKESFE SCKIQVFCIA EEDADAEGLK ADVKKFLYDL
860 870 880 890 900
RMQAEVFVIT MKWDASVDPG SPQDESLDAF TSAKRRIGDY LTQMKASAER
910 920 930 940 950
EGTPLMADGK TVVVNEAQVE KFLYTTLKLN SIILRYSRMA AVVFVSLPPP
960 970 980
PLSHPAYFYM EYMDLLLENI PRILLVRGYR RDVVTLFT
Length:988
Mass (Da):107,282
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1540DE2AE7EF48C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU727216 mRNA Translation: ACE78321.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU727216 mRNA Translation: ACE78321.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C
IPR004842 SLC12A_fam
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF03522 SLC12, 2 hits
TIGRFAMsiTIGR00930 2a30, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3VBE9_9FABA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3VBE9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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