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Protein

Thiol-activated cytolysin

Gene

lly

Organism
Streptococcus sp. SK597
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxinUniRule annotation
Biological processCytolysis, HemolysisUniRule annotation
LigandLipid-bindingUniRule annotation

Protein family/group databases

CAZyiCBM47 Carbohydrate-Binding Module Family 47

Names & Taxonomyi

Protein namesi
Recommended name:
Thiol-activated cytolysinUniRule annotation
Gene namesi
Name:llyImported
OrganismiStreptococcus sp. SK597Imported
Taxonomic identifieri545210 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotation, Host membrane, Membrane, SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36UniRule annotationAdd BLAST36
ChainiPRO_500973587437 – 665Thiol-activated cytolysinUniRule annotationAdd BLAST629

Structurei

3D structure databases

ProteinModelPortaliB3UZR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 183F5/8 type CInterPro annotationAdd BLAST154

Sequence similaritiesi

Belongs to the thiol-activated cytolysin family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane beta strandUniRule annotation

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.1430, 1 hit
3.90.840.10, 1 hit
InterProiView protein in InterPro
IPR000421 FA58C
IPR006585 FTP1
IPR008979 Galactose-bd-like_sf
IPR035390 Thiol_cytolys_C
IPR038700 Thiol_cytolys_C_sf
IPR001869 Thiol_cytolysin
IPR036363 Thiol_cytolysin_ab_sf
IPR036359 Thiol_cytolysin_sf
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF17440 Thiol_cytolys_C, 1 hit
PF01289 Thiol_cytolysin, 1 hit
PRINTSiPR01400 TACYTOLYSIN
SMARTiView protein in SMART
SM00607 FTP, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF56978 SSF56978, 1 hit
PROSITEiView protein in PROSITE
PS50022 FA58C_3, 1 hit

Sequencei

Sequence statusi: Complete.

B3UZR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQEKRLHRF VKKCGLGVCS AVVAAFLLNA QGVALATEQG NRPVETENIA
60 70 80 90 100
RGKQASQSST AYGGAATRAV DGNVDSDYGH HSVTHTNFED NAWWQVDLGK
110 120 130 140 150
TENVGKVKLY NRGDGNVANR LSNFDVVLLN EAKQEVARQH FDSLNGKAEL
160 170 180 190 200
EVFFTAKDAR YVKVELKTKN TPLSLAEVEV FRSATTQVGQ DRTAPVVDQT
210 220 230 240 250
SALKDYLFGL TYNPLDILTR KGETLENRYN TSAKEQNGEF VVVEKIKKTL
260 270 280 290 300
STGTADVSIN GNQNVFLGGL YKANQNLLEN QPELISLARA KGTVSVDLPG
310 320 330 340 350
MIHSENKIEA NPTTSGMQEA MNTLVEKWTK NYSSSHSVPA RVQYESTTAY
360 370 380 390 400
SMNQLKAKFG ADFEKAGAPL KIDFEAVQKG EKQIEVVNFK QIYYTATFDA
410 420 430 440 450
PTNPAAVFDK SVTPEDLKQR GVDSQTPPVY VSNVSYGRQI YVKFESTSKS
460 470 480 490 500
TELKAAINAV IKGATIAPNS EWSRLLKNTS VTAVIVGGNA SGAAKVVTGT
510 520 530 540 550
VENLKELIRE GANFSAQSPA VPISYKTAFL KDNAQATLQN STDYIETKVT
560 570 580 590 600
SYKNGFLKLH HKGAYIARYY IYWDEITYDE QGNPEIRSRQ WEDNGKNRTS
610 620 630 640 650
GFQTEIQFRG NVRNLRIKVQ EKTGLVWEPW RTVYNRTDLP LVQQRTITHW
660
GTTLNPKVDE KIVNE
Length:665
Mass (Da):73,781
Last modified:September 2, 2008 - v1
Checksum:iDC04EDA56B74C2A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU597013 Genomic DNA Translation: ACE79194.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU597013 Genomic DNA Translation: ACE79194.1

3D structure databases

ProteinModelPortaliB3UZR3
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM47 Carbohydrate-Binding Module Family 47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.1430, 1 hit
3.90.840.10, 1 hit
InterProiView protein in InterPro
IPR000421 FA58C
IPR006585 FTP1
IPR008979 Galactose-bd-like_sf
IPR035390 Thiol_cytolys_C
IPR038700 Thiol_cytolys_C_sf
IPR001869 Thiol_cytolysin
IPR036363 Thiol_cytolysin_ab_sf
IPR036359 Thiol_cytolysin_sf
PfamiView protein in Pfam
PF00754 F5_F8_type_C, 1 hit
PF17440 Thiol_cytolys_C, 1 hit
PF01289 Thiol_cytolysin, 1 hit
PRINTSiPR01400 TACYTOLYSIN
SMARTiView protein in SMART
SM00607 FTP, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF56978 SSF56978, 1 hit
PROSITEiView protein in PROSITE
PS50022 FA58C_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB3UZR3_9STRE
AccessioniPrimary (citable) accession number: B3UZR3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 7, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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