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UniProtKB - B3TP03 (CTR2_CHICK)
Protein
Cationic amino acid transporter 2
Gene
SLC7A2
Organism
Gallus gallus (Chicken)
Status
Functioni
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
By similarityGO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
- arginine transmembrane transporter activity Source: GO_Central
- L-arginine transmembrane transporter activity Source: AgBase
- L-lysine transmembrane transporter activity Source: AgBase
- L-ornithine transmembrane transporter activity Source: GO_Central
GO - Biological processi
- amino acid transport Source: GO_Central
- L-arginine import across plasma membrane Source: AgBase
- L-lysine import across plasma membrane Source: AgBase
- L-ornithine transmembrane transport Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
SABIO-RKi | B3TP03 |
Names & Taxonomyi
Protein namesi | Recommended name: Cationic amino acid transporter 2Short name: CAT-2 Short name: CAT2 Short name: cCAT-2 Alternative name(s): Low affinity cationic amino acid transporter 2 Solute carrier family 7 member 2 |
Gene namesi | Name:SLC7A2 Synonyms:ATRC2, CAT2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Golgi apparatus
- Golgi apparatus Source: AgBase
Plasma Membrane
- plasma membrane Source: AgBase
Other locations
- cytoplasm Source: AgBase
- cytoplasmic vesicle Source: AgBase
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | CytoplasmicSequence analysisAdd BLAST | 37 | |
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 59 – 65 | ExtracellularSequence analysis | 7 | |
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 87 – 103 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 125 – 162 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 163 – 183 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 191 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 248 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 249 – 269 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 270 – 289 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 290 – 310 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 311 – 339 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 340 – 360 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 361 – 385 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 386 – 406 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 407 – 409 | ExtracellularSequence analysis | 3 | |
Transmembranei | 410 – 430 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 431 – 489 | CytoplasmicSequence analysisAdd BLAST | 59 | |
Transmembranei | 490 – 510 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 511 – 522 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 523 – 543 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 544 – 554 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 555 – 575 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 576 – 581 | ExtracellularSequence analysis | 6 | |
Transmembranei | 582 – 602 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 603 – 654 | CytoplasmicSequence analysisAdd BLAST | 52 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000375228 | 1 – 654 | Cationic amino acid transporter 2Add BLAST | 654 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 226 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 233 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | B3TP03 |
PRIDEi | B3TP03 |
Expressioni
Tissue specificityi
Expressed in liver, pectoralis and gastrocnemius.1 Publication
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 611 – 654 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 627 – 654 | Basic and acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
InParanoidi | B3TP03 |
PhylomeDBi | B3TP03 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004755, Cat_AA_permease IPR029485, CAT_C |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: B3TP03-1) [UniParc]FASTAAdd to basket
Also known as: cCAT-2A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPCGPALTF VRCLVRKKNI KGEGLEDSLC RCLSTLDLIA LGVGSTLGAG
60 70 80 90 100
VYVLAGEVAK SDSGPSIVVS FLIAALASVM AGLCYAEFGA RVPKTGSAYL
110 120 130 140 150
YTYVAVGELW AFITGWNLIL SYVIGTSSVA RAWSGTFDEL LGKQISHFFK
160 170 180 190 200
TYFKMNYPGL AEYPDFFAVF LILLLSGLLS FGVKESAWVN KIFTAINILV
210 220 230 240 250
LLFVMISGFV KGDVDNWRIS EEYLINLSEI AENFSSYKNV TSIYGSGGFM
260 270 280 290 300
PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVVSLLVCF
310 320 330 340 350
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFA YVGWGPAKYV VAVGSLCALS
360 370 380 390 400
TSLLGSMFPL PRIVFAMARD GLLFSFLAKV SKRQAPLLAT LTAGVISAIM
410 420 430 440 450
AFLFDLKALV DIMSIGTLLA YSLVATCVLI LRYQPSLTYE QPKYSPEKAT
460 470 480 490 500
LAASKRESAV SESQINMIQE SHFSLQTLIN PSSLPTEQTA TTVNCFVGLL
510 520 530 540 550
AFLVCGLSAL TTYGTHFIAN LEPWSICLLA TLVVSFIVTI LLIQRQPQNQ
560 570 580 590 600
QKVAFMVPLL PFLPSLSILV NIYLMVQLSA DTWIRFSIWM ALGFIIYFTY
610 620 630 640 650
GIRHSLEGRH SDGDGDSCSE NSGLQEKNPV EEVDEPENAN ESDKFLARER
TSEC
Isoform 3 (identifier: B3TP03-3) [UniParc]FASTAAdd to basket
Also known as: cCAT-2C
The sequence of this isoform differs from the canonical sequence as follows:
353-358: LLGSMF → YYGISV
359-654: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Lacks the domain responsible for mediating amino acids transport.Curated
Show »Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037356 | 353 – 358 | LLGSMF → YYGISV in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_037357 | 357 – 397 | MFPLP…AGVIS → IFPMPRVIYAMAKDGLLFKC LAQINSKTKTPLVATPSSGA VA in isoform 2. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_037358 | 359 – 654 | Missing in isoform 3. 1 PublicationAdd BLAST | 296 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU360448 mRNA Translation: ACA61195.1 EU360449 mRNA Translation: ACA61196.1 EU360450 mRNA Translation: ACA61197.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU360448 mRNA Translation: ACA61195.1 EU360449 mRNA Translation: ACA61196.1 EU360450 mRNA Translation: ACA61197.1 |
3D structure databases
SMRi | B3TP03 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000041429 |
Proteomic databases
PaxDbi | B3TP03 |
PRIDEi | B3TP03 |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
InParanoidi | B3TP03 |
PhylomeDBi | B3TP03 |
Enzyme and pathway databases
SABIO-RKi | B3TP03 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004755, Cat_AA_permease IPR029485, CAT_C |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CTR2_CHICK | |
Accessioni | B3TP03Primary (citable) accession number: B3TP03 Secondary accession number(s): B3TP04, B3TP05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | September 2, 2008 | |
Last modified: | February 23, 2022 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families