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Entry version 58 (31 Jul 2019)
Sequence version 1 (02 Sep 2008)
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Protein
Submitted name:

Lacto-N-biosidase

Gene

lnbB

Organism
Bifidobacterium bifidum JCM 1254
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei190GalactoseCombined sources1
Binding sitei216GalactoseCombined sources1
Binding sitei259GalactoseCombined sources1
Binding sitei320GalactoseCombined sources1
Binding sitei394N-acetyl-D-glucosamineCombined sources1
Binding sitei419N-acetyl-D-glucosamineCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseImported, Hydrolase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.140 844

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM32 Carbohydrate-Binding Module Family 32
GH20 Glycoside Hydrolase Family 20

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Lacto-N-biosidaseImported (EC:3.2.1.140Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lnbBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBifidobacterium bifidum JCM 1254Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri398514 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1087 – 1106HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500279910835 – 1112Sequence analysisAdd BLAST1078

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi187 ↔ 189Combined sources
Disulfide bondi564 ↔ 589Combined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3TLD6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini960 – 1041BIG2InterPro annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni320 – 321N-acetyl-D-glucosamine bindingCombined sources2
Regioni465 – 467Galactose bindingCombined sources3
Regioni465 – 467N-acetyl-D-glucosamine bindingCombined sources3
Regioni938 – 969DisorderedSequence analysisAdd BLAST32
Regioni1044 – 1081DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1060 – 1079PolarSequence analysisAdd BLAST20

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
3.30.379.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025705 Beta_hexosaminidase_sua/sub
IPR003343 Big_2
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR015883 Glyco_hydro_20_cat
IPR017853 Glycoside_hydrolase_SF
IPR029018 Hex-like_dom2
IPR015882 HEX_bac_N
IPR008964 Invasin/intimin_cell_adhesion
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02368 Big_2, 1 hit
PF00754 F5_F8_type_C, 1 hit
PF00728 Glyco_hydro_20, 1 hit
PF02838 Glyco_hydro_20b, 1 hit
PF14200 RicinB_lectin_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00738 GLHYDRLASE20

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00635 BID_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49373 SSF49373, 1 hit
SSF49785 SSF49785, 1 hit
SSF50370 SSF50370, 1 hit
SSF51445 SSF51445, 1 hit
SSF55545 SSF55545, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3TLD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKSSNRRFG VRTVAAIVAG LMVGGMCTAM TASAADDSAA GYSATAPVNL
60 70 80 90 100
TRPATVPSMD GWTDGTGAWT LGEGTRVVSS DALAARAQSL ASELTKFTDV
110 120 130 140 150
DIKAATGSAT GKDISLTLDA SKKAELGDEG FKLNIGSKGL EVIGATDIGV
160 170 180 190 200
FYGTRSVSQM LRQGQLTLPA GTVATKPKYK ERGATLCACQ INISTDWIDR
210 220 230 240 250
FLSDMADLRL NYVLLEMKLK PEEDNTKKAA TWSYYTRDDV KKFVKKANNY
260 270 280 290 300
GIDVIPEINS PGHMNVWLEN YPEYQLADNS GRKDPNKLDI SNPEAVKFYK
310 320 330 340 350
TLIDEYDGVF TTKYWHMGAD EYMIGTSFDN YSKLKTFAEK QYGAGATPND
360 370 380 390 400
AFTGFINDID KYVKAKGKQL RIWNDGIVNT KNVSLNKDIV IEYWYGAGRK
410 420 430 440 450
PQELVQDGYT LMNATQALYW SRSAQVYKVN AARLYNNNWN VGTFDGGRQI
460 470 480 490 500
DKNYDKLTGA KVSIWPDSSY FQTENEVEKE IFDGMRFISQ MTWSDSRPWA
510 520 530 540 550
TWNDMKADID KIGYPLDIRE YDYTPVDAGI YDIPQLKSIS KGPWELITTP
560 570 580 590 600
DGYYQMKDTV SGKCLALFTG SKHLDVVTQV GARPELRNCA DVSVGQDQRN
610 620 630 640 650
TANERNTQKW QIRADKDGKY TISPALTQQR LAIATGNEQN IDLETHRPAA
660 670 680 690 700
GTVAQFPADL VSDNALFTLT GHMGMSATVD SKTVNPASPS KITVKVRAAS
710 720 730 740 750
NANTGDVTVT PVVPEGWEIK PGSVSLKSIP AGKAAIAYFN VVNTTGTGDA
760 770 780 790 800
TVQFKLTNTK TGEELGTTSV ALTGSLTKDV EASDYAASSQ ETTGEHAPVG
810 820 830 840 850
NAFDKNANTF WHSKYSNPSA NLPHWLAFKA SPGEGNKIAA ITHLYRQDKL
860 870 880 890 900
NGPAKNVAVY VVAASDANSV ADVTNWGEPV ATAEFPYTKE LQTIALPNTI
910 920 930 940 950
PSGDVYVKFQ INDAWGLTET SAGVTWAAVA ELAATAKATP VELTEPEQPK
960 970 980 990 1000
DNPEVTETPE ATGVTVSGDG VANGALSLKK GTTAQLTAKV APDDADQAVT
1010 1020 1030 1040 1050
WASSDDKVVT VDKTGKVTAV AKGVAKVTAT TANGKSASVT VTVTEDSEVP
1060 1070 1080 1090 1100
GPTGPTEPTK PGTEKPTTKP TTKPNDGKLS ATGADTAVLA TIAALFALAG
1110
GAVVAVRRRS VR
Length:1,112
Mass (Da):119,514
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD036BDCD27451F0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU281545 Genomic DNA Translation: ABZ78855.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU281545 Genomic DNA Translation: ABZ78855.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H04X-ray1.80A/B41-663[»]
4JAWX-ray1.80A/B41-663[»]
5BXPX-ray1.70A/B41-663[»]
5BXRX-ray1.60A/B41-663[»]
5BXSX-ray2.20A/B41-663[»]
5BXTX-ray1.80A/B41-663[»]
SMRiB3TLD6
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

CAZyiCBM32 Carbohydrate-Binding Module Family 32
GH20 Glycoside Hydrolase Family 20

Enzyme and pathway databases

BRENDAi3.2.1.140 844

Family and domain databases

Gene3Di2.60.120.260, 1 hit
3.30.379.10, 1 hit
InterProiView protein in InterPro
IPR025705 Beta_hexosaminidase_sua/sub
IPR003343 Big_2
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR015883 Glyco_hydro_20_cat
IPR017853 Glycoside_hydrolase_SF
IPR029018 Hex-like_dom2
IPR015882 HEX_bac_N
IPR008964 Invasin/intimin_cell_adhesion
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF02368 Big_2, 1 hit
PF00754 F5_F8_type_C, 1 hit
PF00728 Glyco_hydro_20, 1 hit
PF02838 Glyco_hydro_20b, 1 hit
PF14200 RicinB_lectin_2, 1 hit
PRINTSiPR00738 GLHYDRLASE20
SMARTiView protein in SMART
SM00635 BID_2, 1 hit
SUPFAMiSSF49373 SSF49373, 1 hit
SSF49785 SSF49785, 1 hit
SSF50370 SSF50370, 1 hit
SSF51445 SSF51445, 1 hit
SSF55545 SSF55545, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3TLD6_BIFBI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3TLD6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 31, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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