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Protein

Endolysin

Gene
N/A
Organism
Escherichia phage V5
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endolysin with transglycosylase activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.UniRule annotation

Catalytic activityi

Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei20UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzymeUniRule annotation, LyaseUniRule annotation
Biological processCytolysis, Host cell lysis by virusUniRule annotation, Viral release from host cell

Protein family/group databases

CAZyiGH104 Glycoside Hydrolase Family 104

Names & Taxonomyi

Protein namesi
Recommended name:
EndolysinUniRule annotation (EC:4.2.2.n2UniRule annotation)
Alternative name(s):
Lysis proteinUniRule annotation
LysozymeUniRule annotation
TransglycosylaseUniRule annotation
OrganismiEscherichia phage V5Imported
Taxonomic identifieri399183 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeVequintavirinae
Proteomesi
  • UP000203832 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Note: The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.UniRule annotation

Family and domain databases

CDDicd00736 bacteriophage_lambda_lysozyme, 1 hit
HAMAPiMF_04109 ENDOLYSIN_LAMBDA, 1 hit
InterProiView protein in InterPro
IPR034691 Endolysin_lambda_type
IPR002196 Glyco_hydro_24
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00959 Phage_lysozyme, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit

Sequencei

Sequence statusi: Complete.

B3RGM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLDKNVQRK AFLDMIAYSE GTDNGRQPTK DRGYDVIVGG KLFSDYSKHP
60 70 80 90 100
GVYVKLNAKL TSSAAGRYQV LEKFAKHYMK QLGLPDFGPA SQDKIALQLI
110 120 130 140 150
RECKALADID EGRIHEAIHK CRSRWASLPG AGYGQHEQKI EKLIEVFKKA

GGVVLD
Length:156
Mass (Da):17,422
Last modified:September 2, 2008 - v1
Checksum:i6AEDE7D52C801970
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ832317 Genomic DNA Translation: ABI79155.1
RefSeqiYP_002003587.1, NC_011041.1

Genome annotation databases

GeneIDi6446805
KEGGivg:6446805

Similar proteinsi

Entry informationi

Entry nameiB3RGM4_9CAUD
AccessioniPrimary (citable) accession number: B3RGM4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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