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Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Rhizobium etli (strain CIAT 652)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99MagnesiumUniRule annotation1
Binding sitei102XanthineUniRule annotation1
Binding sitei145Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processPurine salvageUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotationImported
Ordered Locus Names:RHECIAT_CH0001840Imported
OrganismiRhizobium etli (strain CIAT 652)Imported
Taxonomic identifieri491916 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000008817 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi491916.RHECIAT_CH0001840

Structurei

3D structure databases

ProteinModelPortaliB3PX12
SMRiB3PX12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 153PribosyltranInterPro annotationAdd BLAST142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 425-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni102 – 1065-phosphoribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DYA Bacteria
COG0503 LUCA
HOGENOMiHOG000226805
KOiK00769
OMAiFHRDCRA
OrthoDBiPOG091H03MJ

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01903 XGPRT, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023747 Xanthine_Guanine_PRibTrfase
PANTHERiPTHR39563 PTHR39563, 1 hit
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

B3PX12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPDKAFPV SWDQFHRDAR ALAWRLAGLD QTFKAIVCIT RGGLVPAAII
60 70 80 90 100
SRELNIRLIE TVCIASYHDY VNQGDMVLLK GIAPELAENG GEGVLVVDDL
110 120 130 140 150
TDTGKTAAQV RTMLPKAHFA CVYAKPKGVP TVDTFITEVS QDTWIYFPWD
160
MGFTYQEPIA KGAR
Length:164
Mass (Da):18,116
Last modified:September 2, 2008 - v1
Checksum:i6633F9EEE570A173
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001074 Genomic DNA Translation: ACE90810.1
RefSeqiWP_010025058.1, NC_010994.1

Genome annotation databases

EnsemblBacteriaiACE90810; ACE90810; RHECIAT_CH0001840
GeneIDi24300151
KEGGirec:RHECIAT_CH0001840

Similar proteinsi

Entry informationi

Entry nameiB3PX12_RHIE6
AccessioniPrimary (citable) accession number: B3PX12
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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