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UniProtKB - B3NNY7 (B3NNY7_DROER)

Entry version 67 (02 Dec 2020)
Sequence version 1 (02 Sep 2008)
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Protein

RNase III domain-containing protein

Gene

Dere\GG20085

Organism
Drosophila erecta (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNase III domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dere\GG20085Imported
ORF Names:Dere_GG20085Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila erecta (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7220 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008711 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7220.FBpp0138631

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini775 – 843RNase IIIInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni419 – 439DisorderedSequence analysisAdd BLAST21
Regioni1014 – 1074DisorderedSequence analysisAdd BLAST61
Regioni1256 – 1287DisorderedSequence analysisAdd BLAST32
Regioni1406 – 1427DisorderedSequence analysisAdd BLAST22
Regioni1583 – 1636DisorderedSequence analysisAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili641 – 661Sequence analysisAdd BLAST21
Coiled coili768 – 788Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1038 – 1065PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1408 – 1423PolarSequence analysisAdd BLAST16
Compositional biasi1609 – 1628PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3630, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_247466_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		KCGCWSP

Database of Orthologous Groups

More...OrthoDBi		275785at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		B3NNY7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026054, Nucleoporin
IPR000999, RNase_III_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR23193, PTHR23193, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50142, RNASE_3_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3NNY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQNAPDCKD TQDFQFKLHD KFVAFKKCGE PRSNVNLLAV SSSRGLLFAG 
        60         70         80         90        100
SPTQPELKVI IVKDLANAKI TGEQPQARLV SLPSIPNYIA CSSDGNLLAV 
       110        120        130        140        150
NHTQNGTSLL SIYAVPTFMT PDVRPVYNIR LAAEDHVHAV QLLWNPVLPN 
       160        170        180        190        200
SLAVVLSNGA LGMYALKEGG NFEMHSLDKN QQVKCGCWSP KGKQIVLGFP 
       210        220        230        240        250
GGKVQQFKPD LTPAKTLLCP PNIHDAPFDT IAIQWLSTFQ FAVIFLQHGE 
       260        270        280        290        300
DCNPSLYILN APKAGAPSYT NYYDICYSMN GPRNHQFLFC HVPQWNLLLV 
       310        320        330        340        350
VSANGVEVGI MGTSEAGDTP AWQQFTLLDE ARIEMPLSEE KEETFPLGFA 
       360        370        380        390        400
FDTSSTHQLT INEQKLQTMP MVHVLSSDGL LLSFNFLNVL PTVVSVCSPP 
       410        420        430        440        450
PPVADTSGQF RPLNTLLPSE EEEQPAVAAS PPSKAPAVTP AASSDISFAF 
       460        470        480        490        500
TSNTVTSTPA PSKDKSASLF SGFGAAAAKA PAPQLSFGTA ATSSPLSFGA 
       510        520        530        540        550
PASNTSKPTT PFGGFGTQAT PTALGTMFSA PGTNTFGGMA LTKSPVGSVA 
       560        570        580        590        600
PTLVRKSTAL ATASAPANKP LYTVPPTYTP VDTKPATSAA PTAEESLKLD 
       610        620        630        640        650
DTEPIIKDMI ALQIEAFSQD IQKQKDQTMQ LLKGISAPSA LRAYAKRLDD 
       660        670        680        690        700
LQELNEQAKD VEFELDVQGL RHGLNEAYAI VAECRGKLEI YRKPEITRLM 
       710        720        730        740        750
NSSSCDPAGR RMLARLQSYV AANEAQLRLA QQHVDVQWEQ FQDVVRRNSK 
       760        770        780        790        800
SRMHMPCLEG IYQRLTKLQN LASDLRILQS NIKTKLKERG LLQAALLDQE 
       810        820        830        840        850
KSRTRTNEAV DTLADSILSM SLSQVVDSNA AKLTQQRLQK IRNVVQLQKI 
       860        870        880        890        900
NVICPQRPDR VGLKSEVILE TKRRAEQIKK AAAKPTTANK YTQAAVAPPP 
       910        920        930        940        950
KPAVASTPAV ASTPAVAPMP QTLPLPKPMP SKPSVVEKPG VPPTHPNNPV 
       960        970        980        990       1000
ATSFSFSQSS PFVKTSTVTP TTNTLTPGEA AKPGLSMFGG LGSTAASFSF 
      1010       1020       1030       1040       1050
GGGGAKSTLS FGAGSPAVAA PTSQPSPLAA IKNLTPEPTK PKEQKATSEF 
      1060       1070       1080       1090       1100
KAVKPETEES KLPPQTPKAE TENKSFGFGG FTGTGGTVGN ASSSPFSFGG 
      1110       1120       1130       1140       1150
SGSSLGFGGT AATVPKSESS STTTTSVATP ASTAPFGMFS TAFAKPPNSE 
      1160       1170       1180       1190       1200
VITTVTSSTT SITSKPTPVS DSISATDTPA VTTTKAVTSS SDPIGGLFSS 
      1210       1220       1230       1240       1250
VNICKPNTQA DPTKPANIFG GLNSGSSSGS FSFGGGTVDA SKGLFGSTSP 
      1260       1270       1280       1290       1300
VATATTAPTS VTEAKNKTDP ISTTASTNST TNTTTAVSSP AVIPPAVAPA 
      1310       1320       1330       1340       1350
VLATSSTAVT SSTAVPGSAF SFSNAFSTLS AGGAASPTTI ASAPLAASSS 
      1360       1370       1380       1390       1400
TATTASNSST SVFGGGFAAA TSTAASGANP FQSAAKSPIS SGNIFGSIPK 
      1410       1420       1430       1440       1450
ADDTVFGGAT TASPNTTAAA TPATTPAAPP AGLFASAAIS NPSPFGSPTT 
      1460       1470       1480       1490       1500
GAPASGGNIF GQAVKPSVFG QPAQTGDSGG SIFGGGSAST PFGSSSIFGG 
      1510       1520       1530       1540       1550
SNAQSAVGAP TAGSTSIFGQ NVFGQSAAAA PAAGGNIFSN PVGSPQASAF 
      1560       1570       1580       1590       1600
GGGGNSIFGS PATAAASPAS GGSIFGGGSS SGGFGSFTQT TPAQGGFGGG 
      1610       1620       1630       1640       1650
FAQGGGGSVA QTGFGSPQTP QQQSTPGGFG AKPVFGGSPA FGANPTFGGG 
      1660       1670       1680       1690       1700
ATFGSPKGFG GFGGASPVAS PPAFGAAAKP AQGNIFETLG GQESGISFGN 
      1710       1720 
LAQIGNSNTQ KPAFGGSSFM NYR
Length:1,723
Mass (Da):175,871
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20800B6002ED68A1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH954179 Genomic DNA Translation: EDV56720.1

NCBI Reference Sequences

More...RefSeqi		XP_001976320.1, XM_001976284.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0140139; FBpp0138631; FBgn0112279

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6547375

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		der:6547375

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH954179 Genomic DNA Translation: EDV56720.1
RefSeqiXP_001976320.1, XM_001976284.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7220.FBpp0138631

Genome annotation databases

EnsemblMetazoaiFBtr0140139; FBpp0138631; FBgn0112279
GeneIDi6547375
KEGGider:6547375

Phylogenomic databases

eggNOGiKOG3630, Eukaryota
HOGENOMiCLU_247466_0_0_1
OMAiKCGCWSP
OrthoDBi275785at2759
PhylomeDBiB3NNY7

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR026054, Nucleoporin
IPR000999, RNase_III_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR23193, PTHR23193, 1 hit
PROSITEiView protein in PROSITE
PS50142, RNASE_3_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3NNY7_DROER
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3NNY7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: December 2, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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