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Protein

L-lactate dehydrogenase

Gene

Dana\GF10902

Organism
Drosophila ananassae (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (Dana\GF10902), L-lactate dehydrogenase (Dana\GF13705)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106SubstrateUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Active sitei193Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:Dana\GF10902Imported
ORF Names:Dana_GF10902Imported, GF10902Imported
OrganismiDrosophila ananassae (Fruit fly)Imported
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007801 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0087942 Dana\GF10902

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0087942

Interactioni

Protein-protein interaction databases

STRINGi7217.FBpp0114094

Structurei

3D structure databases

SMRiB3M9Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 160Ldh_1_NInterPro annotationAdd BLAST139
Domaini163 – 324Ldh_1_CInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
InParanoidiB3M9Z0
KOiK00016
OMAiMDLMQTA
OrthoDBiEOG091G0HME

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

B3M9Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIKDSLLA QVAEVLPSSG HKVTVVGIGQ VGMASAFSIL AQNVSKEVCL
60 70 80 90 100
IDVCQDKLQG ELMDLQHGSN FLKNPQITAS TDFAASANSR LCIVTAGVRQ
110 120 130 140 150
KEGESRLSLV QRNTDILKNI IPKLVEYSPD TILLMVSNPV DIMTYVAWKL
160 170 180 190 200
SGLPKNRVIG SGTNLDSSRF RFLMSQRLGV APTSCHGWII GEHGDSSVPV
210 220 230 240 250
WSGVNIAGVR LRELNPTLGT GEDPEKWNEL HKQVVDSAYE VIKLKGYTSW
260 270 280 290 300
AIGLSTASLA SAILRNTSSV AAVSTSVLGE HGIDKDVFLS LPCILNANGV
310 320 330
TSVVKQILTP TEIEQLQKSA TIMADVQAGL KF
Length:332
Mass (Da):35,567
Last modified:September 2, 2008 - v1
Checksum:i5E50A3C22CE35063
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902618 Genomic DNA Translation: EDV41210.1
CH902618 Genomic DNA Translation: KPU79002.1
RefSeqiXP_001958404.1, XM_001958368.2
XP_014764534.1, XM_014909048.1

Genome annotation databases

EnsemblMetazoaiFBtr0115602; FBpp0114094; FBgn0087942
FBtr0391203; FBpp0350673; FBgn0087942
GeneIDi6493769
KEGGidan:Dana_GF10902

Similar proteinsi

Entry informationi

Entry nameiB3M9Z0_DROAN
AccessioniPrimary (citable) accession number: B3M9Z0
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 20, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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