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Entry version 96 (02 Jun 2021)
Sequence version 2 (20 Jan 2016)
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Protein

Peroxidase

Gene

Dana\GF10247

Organism
Drosophila ananassae (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxideARBA annotation
LigandHemeARBA annotation, Iron, Metal-binding

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
7649, DanPxd01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PeroxidaseARBA annotation (EC:1.11.1.7ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dana\GF10247Imported
ORF Names:Dana_GF10247Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila ananassae (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7217 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007801 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500645457127 – 1563PeroxidaseSequence analysisAdd BLAST1537

Keywords - PTMi

Disulfide bondARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0087288, Expressed in adult organism and 1 other tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7217.FBpp0113439

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3M7Y3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini239 – 324Ig-likeInterPro annotationAdd BLAST86
Domaini364 – 452Ig-likeInterPro annotationAdd BLAST89
Domaini457 – 545Ig-likeInterPro annotationAdd BLAST89
Domaini553 – 643Ig-likeInterPro annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni329 – 369DisorderedSequence analysisAdd BLAST41
Regioni1371 – 1393DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1416 – 1443Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi329 – 356Polar residuesSequence analysisAdd BLAST28
Compositional biasi1371 – 1392Basic and acidic residuesSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, Leucine-rich repeatARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619, Eukaryota
KOG2408, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006087_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B3M7Y3

Identification of Orthologs from Complete Genome Data

More...
OMAi
GTNDFKE

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09826, peroxidasin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR034824, Peroxidasin_peroxidase
IPR001007, VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07679, I-set, 2 hits
PF13855, LRR_8, 2 hits
PF00093, VWC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SM00369, LRR_TYP, 5 hits
SM00013, LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48113, SSF48113, 1 hit
SSF48726, SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 4 hits
PS51450, LRR, 6 hits
PS50292, PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3M7Y3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSPGVRPVL WLQLLGLVLI FGGAESVYCP AGCNCLERTV RCIRAKLSAV
60 70 80 90 100
PQVPQDTQVL DLRFNHIEEL PANAFSGLPQ LTTLFLNDNE LAYLQDGALN
110 120 130 140 150
GLPALRFLYL NNNRLSRLPA TIFQRLPRLE ALSLENNDIW QLPSGLFDNL
160 170 180 190 200
PRLNRLILFK NKLTQLPVDA FNRLHSLKRL RLDSNAIDCN CGIYSLWRRW
210 220 230 240 250
HLDVQRQLVD ISLTCASPQH LQKQSFGSLS EQHFKCAKPQ FLVIPQDTQA
260 270 280 290 300
ASGEQVVLSC EVTGLPRPQV TWMHNTNELG EEQTGSEVLA SGSLLIRSVS
310 320 330 340 350
ARDMGIYQCI VRNEMGELRS QPVRLVVNNN APAGGGEQES ENQVWAVAGS
360 370 380 390 400
SPTSSSLPSS PAPPKFTHQP HDQIVALHGP GHVLLDCAAS GSPQPDIQWF
410 420 430 440 450
VNGRQLTQSR PDLQLQANGS LVLVQPTQLS AGTYRCEAHN SLGFVQATAR
460 470 480 490 500
IEVKELPEIL MPPQNQTIKL GKAFVLECDA DGNPLPTIDW QFNDQPLIPG
510 520 530 540 550
SRADLLLENE NTELVVSSAR QEHAGVYRCT ARNENGEVSA EATIKVERSQ
560 570 580 590 600
TPPRVAIEPS NLVAITGTTI ELPCQAEQPE DGLQILWRRD GRLIDPNVQL
610 620 630 640 650
TEKYQISGTG SLFVKNVTIL DGGRYECQLK NQFGRASASA LVTIRNNVDL
660 670 680 690 700
APGDRYVRIA FAEAAKEIDL AINNTLDMLF SNRSDRVQPN YGELLRVFRF
710 720 730 740 750
PTGQARQLAR AAEIYERTLV NIRKHVQRGD NLTMESEKYE FRDLLSREHL
760 770 780 790 800
HLVAELSGCM EHREMPNCTD MCFHSRYRSI DGTCNNLQNP TWGASLTAFR
810 820 830 840 850
RLAPPIYENG FSMPVGWTKG MLYSGHAKPS ARLVSTSLVA TKDITPDARI
860 870 880 890 900
THMVMQWGQF LDHDLDHAIP SVSSESWDGI DCKKSCEMAP PCYPIEVPPN
910 920 930 940 950
DPRVRNRRCI DVVRSSAICG SGMTSLFFDS VQHREQINQL TSYVDASQVY
960 970 980 990 1000
GYATPFAQEL RNLTSEEGLL RVGVHFPRQK DMLPFAAPQD GMDCRRNLDE
1010 1020 1030 1040 1050
NTMSCFVSGD IRVNEQVGLL AMHTIWMREH NRLARKLKQI NPHWDGDTLY
1060 1070 1080 1090 1100
QEARKIVGAQ MQHITFKQWL PLIIGESGMK MMDQNPGYNP QLNPSIANEF
1110 1120 1130 1140 1150
ATAALRFGHT IINPILHRLN ETFQPIPQGH LPLHKAFFAP WRLAYEGGVD
1160 1170 1180 1190 1200
PLMRGFLAVP AKLKTPDQNL NTELTEKLFQ TAHAVALDLA AINIQRGRDH
1210 1220 1230 1240 1250
GMPGYNVYRK MCNLTVAQDF EDLAGEISNA EIRQKMKELY GHPDNVDVWL
1260 1270 1280 1290 1300
GGILEDQVEG GKVGPLFQCM LVEQFRRLRD GDRLYYENPG VFTPEQLVQI
1310 1320 1330 1340 1350
KQTNFGRVLC DVGDNFDQVT ENVFILAKHQ GGYKKCEDIP GINLYLWQEC
1360 1370 1380 1390 1400
GRCNDKPAIF DSYIPETYTK RSSRKRRDLQ GKQEHDEVTT AESYDSPLEA
1410 1420 1430 1440 1450
LYDVNEERVS GLEELIGSFQ KDLKKLHKKL RKLEESCNSV DSEPVAQVVQ
1460 1470 1480 1490 1500
LAAAPVSVPV QGKQRRSHCV DDKGTTRLNN EVWSPDVCTK CNCFHGQVNC
1510 1520 1530 1540 1550
LRERCGEVSC PPGVEPLTAS GGLLPTLPAC QVNHPQPKNY AYRRTRLSVV
1560
APLTLIEKPS ITK
Length:1,563
Mass (Da):175,090
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A9ABF6E958A9882
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH902618 Genomic DNA Translation: EDV39891.2

NCBI Reference Sequences

More...
RefSeqi
XP_001957085.2, XM_001957049.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902618 Genomic DNA Translation: EDV39891.2
RefSeqiXP_001957085.2, XM_001957049.2

3D structure databases

SMRiB3M7Y3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7217.FBpp0113439

Protein family/group databases

PeroxiBasei7649, DanPxd01

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
KOG2408, Eukaryota
HOGENOMiCLU_006087_0_1_1
InParanoidiB3M7Y3
OMAiGTNDFKE

Gene expression databases

BgeeiFBgn0087288, Expressed in adult organism and 1 other tissue

Family and domain databases

CDDicd09826, peroxidasin_like, 1 hit
Gene3Di1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR034824, Peroxidasin_peroxidase
IPR001007, VWF_dom
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07679, I-set, 2 hits
PF13855, LRR_8, 2 hits
PF00093, VWC, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SM00369, LRR_TYP, 5 hits
SM00013, LRRNT, 1 hit
SUPFAMiSSF48113, SSF48113, 1 hit
SSF48726, SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 4 hits
PS51450, LRR, 6 hits
PS50292, PEROXIDASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3M7Y3_DROAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3M7Y3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: January 20, 2016
Last modified: June 2, 2021
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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