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Entry version 81 (02 Jun 2021)
Sequence version 1 (02 Sep 2008)
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Protein

SWIRM domain-containing protein

Gene

Dana\GF25315

Organism
Drosophila ananassae (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei302FADUniRule annotation1
Binding sitei308FADUniRule annotation1
Binding sitei806FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi273 – 301FADUniRule annotationAdd BLAST29
Nucleotide bindingi324 – 325FADUniRule annotation2
Nucleotide bindingi815 – 816FADUniRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported
LigandFADUniRule annotation, Flavoprotein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SWIRM domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dana\GF25315Imported
ORF Names:Dana_GF25315Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila ananassae (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7217 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007801 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0102307, Expressed in adult organism and 1 other tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7217.FBpp0128507

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3M4Q6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini166 – 265SWIRMInterPro annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 166DisorderedSequence analysisAdd BLAST166
Regioni866 – 895DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili433 – 460Sequence analysisAdd BLAST28
Coiled coili493 – 513Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi39 – 57Polar residuesSequence analysisAdd BLAST19
Compositional biasi89 – 119Polar residuesSequence analysisAdd BLAST31
Compositional biasi125 – 148Polar residuesSequence analysisAdd BLAST24
Compositional biasi867 – 895Polar residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0029, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004498_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B3M4Q6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNYAGNC

Database of Orthologous Groups

More...
OrthoDBi
1034142at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B3M4Q6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002937, Amino_oxidase
IPR036188, FAD/NAD-bd_sf
IPR017366, Hist_Lys-spec_deMease
IPR009057, Homeobox-like_sf
IPR007526, SWIRM
IPR036388, WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01593, Amino_oxidase, 1 hit
PF04433, SWIRM, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038051, Histone_Lys-demethylase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF51905, SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50934, SWIRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3M4Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPTQTGGSG TKMSEPIEYV TLISDDSDGE PSPKRNAPPP GHTSTAASST
60 70 80 90 100
AAQKQKPVPD DDSNDAPAGS TTAGDERRTS RRNKPKVDYS NRQGGSVENA
110 120 130 140 150
NTEKSNTATV SGKDQVDRRS QNQTQARKSE AISTSVSGQA ATNPRPSQNG
160 170 180 190 200
DSKERDVGTP TVLSGQEGAV FQSRLPFSKM TPNEEACFPD ISRSGILGHR
210 220 230 240 250
VFLNIRNSLL HMWVDNPKVQ LSYENAMKAL PPPFDSEPSL VRRVHSFLER
260 270 280 290 300
HGFINFGIFK RQRPIPTKKL GKVIVIGAGI SGLAVAQQLQ QFGMDVIVLE
310 320 330 340 350
ARDRVGGRIA TFRKNSYIAD LGAMVVTGVY GNPMTILSKQ IGMDLVPIQQ
360 370 380 390 400
TCPLYGPDGK PVAKEKDDVI EREFNRLLES ASYLSHRLDF NYAGNCPVSL
410 420 430 440 450
GDALEWIISM QEMQVMNKRA VHMQEIIAAQ TKIIEHRQRL KSVKQNIANL
460 470 480 490 500
KTEHQALLKQ PKPKGTANAA TYARQEFNKR NTQIKLEDTM KLYGELHEED
510 520 530 540 550
KRLEAKLREL EQNRPSDVYL SSRDRLLLDW HFANLEFANA TRLNNLSLKH
560 570 580 590 600
WDQDDDFEFI GHHTTVRNGY SCVPVALTEN LDIRVNSAVK EIKYGTNGVE
610 620 630 640 650
VVAENLKTSN SLMSYKADLV VCTLTLGVLK LAVAHEESQQ SNTVKFDPPL
660 670 680 690 700
PDWKQQAIRR LGFGNLNKVV LCFDRIFWDP NANLFGHVGS TTSSRGEMFL
710 720 730 740 750
FWSISSSPVL LALVAGMSAN IVESVTDDII IGRCMSVLKN IFGNTSVPQP
760 770 780 790 800
KETVVTRWRS DPWARGSYSY VSVGSSGSDY DLLAAPVIPP TCKEPEGLPR
810 820 830 840 850
LFFAGEHTIR NYPATVHGAY LSGLREAGRI ADYYLGYPEG TPPDIGYSVA
860 870 880 890
EAANSVSVGN VVKLRDLSPN LSDSPSSKKS EENSSSNTAD SAELQ
Length:895
Mass (Da):98,582
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CF907189214AC34
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH902618 Genomic DNA Translation: EDV39455.1

NCBI Reference Sequences

More...
RefSeqi
XP_001956649.1, XM_001956613.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0130015; FBpp0128507; FBgn0102307

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6507938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dan:6507938

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902618 Genomic DNA Translation: EDV39455.1
RefSeqiXP_001956649.1, XM_001956613.2

3D structure databases

SMRiB3M4Q6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7217.FBpp0128507

Genome annotation databases

EnsemblMetazoaiFBtr0130015; FBpp0128507; FBgn0102307
GeneIDi6507938
KEGGidan:6507938

Phylogenomic databases

eggNOGiKOG0029, Eukaryota
HOGENOMiCLU_004498_5_1_1
InParanoidiB3M4Q6
OMAiFNYAGNC
OrthoDBi1034142at2759
PhylomeDBiB3M4Q6

Gene expression databases

BgeeiFBgn0102307, Expressed in adult organism and 1 other tissue

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR002937, Amino_oxidase
IPR036188, FAD/NAD-bd_sf
IPR017366, Hist_Lys-spec_deMease
IPR009057, Homeobox-like_sf
IPR007526, SWIRM
IPR036388, WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01593, Amino_oxidase, 1 hit
PF04433, SWIRM, 1 hit
PIRSFiPIRSF038051, Histone_Lys-demethylase, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF51905, SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50934, SWIRM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3M4Q6_DROAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3M4Q6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 2, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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