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Entry version 74 (16 Jan 2019)
Sequence version 1 (02 Sep 2008)
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Protein
Submitted name:

Uncharacterized protein

Gene

Dana\GF18290

Organism
Drosophila ananassae (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported, RNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported (EC:3.1.26.3Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dana\GF18290Imported
ORF Names:Dana_GF18290Imported, GF18290Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila ananassae (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7217 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007801 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0095308 Dana\GF18290

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0095308 Expressed in 1 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7217.FBpp0121482

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini483 – 659Helicase C-terminalInterPro annotationAdd BLAST177
Domaini826 – 921Dicer dsRNA-binding foldInterPro annotationAdd BLAST96
Domaini1100 – 1247PAZInterPro annotationAdd BLAST148
Domaini1713 – 1922RNase IIIInterPro annotationAdd BLAST210
Domaini1996 – 2153RNase IIIInterPro annotationAdd BLAST158
Domaini2178 – 2244DRBMInterPro annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili178 – 198Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
COG0571 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B3LZQ9

KEGG Orthology (KO)

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KOi
K11592

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKPDQPC

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B3LZQ9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3LZQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFHWCDNNL HTTVFTPRDF QVELLASAFE RNTIICLGHR SSKEFIALKL
60 70 80 90 100
LQELSRRARC RGKVSVYLST QVGRNTEPTS IYTMLSHLTD LRVWQEQPDM
110 120 130 140 150
QVPFDHCWTD YNVSILRPEE FISLLEAREL LLSSVELIVL EDCHDSEVYR
160 170 180 190 200
RILPLFEDHI LPAAHHDRPR ILGLAGPLHS AECELQELSA MLATLERNIL
210 220 230 240 250
CRIETASDIV TVLRYCSRPH EYIVQCAPYE MDDLSLVLAD VLNTHKAFLT
260 270 280 290 300
DHRYDPYEIY GTDQFMEDLK DIPDPKLDPL NVINSLLAVL HEMGPWCTQR
310 320 330 340 350
AAQHFYQTNE KLKVKTPHER HYLLYCLVST ALTQLHALCD HTFQRQQAAG
360 370 380 390 400
EDPRHIVERY SSPKVRRLLQ TLRCFKPEEN LTQVDGMRKM RHQVEQADFG
410 420 430 440 450
RLSQALESKC QLVDQLEQPP IETRALVAHL EQILHSSEEK KQAKCNFHAT
460 470 480 490 500
TTAPTVHGKR KSAETGTQPR ARRRVYTRRH HRDQNDGSDT LCGLIYCNQN
510 520 530 540 550
HTARVLFELL AEMSRRDPNL KFLRCQYTTD RVADPATEPK EAELEHRRQE
560 570 580 590 600
EVLKRFRMHD CNVLIGTSIL EEGIDVPKCN LVVRWDPPTT YRSYVQCKGR
610 620 630 640 650
ARAAPAYHVI LVAPSFETPP VDSVELTDES HRFICGAPAA GESQEAESDS
660 670 680 690 700
DDSAIPNSIG SDPYTFGTAR GTVKILNPEV FSNQPPTACD IRLQEIQDDP
710 720 730 740 750
GVQMDTSNSS DEAVSLSNTT TSDSSVERKP RQRFRCELSV QSESEVASPS
760 770 780 790 800
THTEKSSVDG LTTTTTELVH QMAQYREIEQ MLLSKCANTE PSELEQHDAE
810 820 830 840 850
RFSGCLAAYR PKPQLLTGAS VDLGSAIALI NKYCARLPSD TFTKLTALWR
860 870 880 890 900
CTRSERAGKT LYQYTLRLPI NSPLKHDIVG LPMPTQTLAR RLAALQACAE
910 920 930 940 950
LHRIGELDDQ LQPIGKEGFR ALEADWECFD LEPEDEQILQ MSDEPRPGTT
960 970 980 990 1000
KRRQYYYKRI ASEFCDCRPV AGAPCYLYFI QLTLQCPIPE EQNTRGRKIY
1010 1020 1030 1040 1050
PPEDAQQGFG ILTTKRIPKL SAFSIFTRSG EVKVSLELAK EQVVLTSEQI
1060 1070 1080 1090 1100
GCINGFLNYT FTNVLRLQKF LMLFDPDSTE NCVFIVPTVK MPAGGKMIDW
1110 1120 1130 1140 1150
KFLDVIQANG NTLPREVPDE ERLAKPFDAQ CFQDAVVMPW YRNQDQPQYF
1160 1170 1180 1190 1200
YVAEICPHLS PLSCFPGEQY RTFKHYYYAK YGLNIQNSSQ PLLDVDHTSA
1210 1220 1230 1240 1250
RLNFLTPRYV NRKGVALPTS SEETKRAKRE NLEQKQILVP ELCTVHPFPA
1260 1270 1280 1290 1300
SLWRTAVCLP CILYRINGLL LADDIRKQVS TDLGLGQQQI EDEEFQWPML
1310 1320 1330 1340 1350
DFGWSLSEVL KKSRESKQRD VGKDVEVNTK EPKGGQGDAT KKDIKVEAQS
1360 1370 1380 1390 1400
NDDKKEKSAN ELIIEGEQKL QEADDFIEIG TWSNDMADDI ASFNPGDDEE
1410 1420 1430 1440 1450
EDDAFLPVLP ANVKFCDQQT RYGSPTFWDV KNGEGGFKQP KRSQQPQQGG
1460 1470 1480 1490 1500
NSKAKGSGKP TYNYYDSDNS LGSSYDDDDH GGPLNYMHHN YSTDDDDVED
1510 1520 1530 1540 1550
EIDAGRIAFT SKNEAETIET AQEVEKRQKQ LSIIQATNAN ERQYQETKNL
1560 1570 1580 1590 1600
LIGFNFQQEL RESLTVSSGD YEQSISRLQE EIRNCGMLVP HSEELVLKRK
1610 1620 1630 1640 1650
DPVEAQHGKD SMLELLKQLL PYVQEEELAK RLINRKNFQL SDLVELNADW
1660 1670 1680 1690 1700
VARNGEEVHQ VLGCGDSFDN YNDHNRLNLE NKELTLQYER KSILPAVPEK
1710 1720 1730 1740 1750
ATSFSTLPKG FSFDRQPGLV GHPGPSPSII LQALTMSNAN DGINLERLET
1760 1770 1780 1790 1800
IGDSFLKYAI TTYLYITYEN VHEGKLSHLR SKQVANLNLY RLGRRKRLGE
1810 1820 1830 1840 1850
YMIATKFEPH DNWLPPCYYV PKELEKALIE AKIPTHHWKL ADLLDIKNLS
1860 1870 1880 1890 1900
SVQICELVRE KAEALGLEQN GPQSGQLDDS NDSCNDFSCF IPYNLVSQHS
1910 1920 1930 1940 1950
IPDKSIADCV EALIGAYLIE CGPRGALLFM AWLGIRVLPF TRQPAEQEEA
1960 1970 1980 1990 2000
KRVPGSSKSD AEGMVTVYGA WPTPRSPLLH FAPNATGELD QLLSGFEEFE
2010 2020 2030 2040 2050
ASLGYKFRDR SYLLQAMTHA SYTPNRLTDC YQRLEFLGDA VLDYLITRHL
2060 2070 2080 2090 2100
YEDPRQHSPG ALTDLRSALV NNTIFASLAV RHGFHKFFRH LSPGLNDVID
2110 2120 2130 2140 2150
RFVRIQQENG HSISEEYYLL SEEECDDAED VEVPKALGDV FESIAGAIFL
2160 2170 2180 2190 2200
DSNMSLDVVW QVYSNMMSPE IEQFSNSVPK SPIRELLELE PETAKFGKPE
2210 2220 2230 2240 2250
KLADGRRVRV TVDVFCKGTF RGIGRNYRIA KCTAAKCALR QLKKQGLIAK

KD
Length:2,252
Mass (Da):255,826
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16E7F66ABFC2E0F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH902617 Genomic DNA Translation: EDV43053.1

NCBI Reference Sequences

More...
RefSeqi
XP_001954492.1, XM_001954456.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0122990; FBpp0121482; FBgn0095308

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6501066

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dan:Dana_GF18290

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH902617 Genomic DNA Translation: EDV43053.1
RefSeqiXP_001954492.1, XM_001954456.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7217.FBpp0121482

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0122990; FBpp0121482; FBgn0095308
GeneIDi6501066
KEGGidan:Dana_GF18290

Organism-specific databases

FlyBaseiFBgn0095308 Dana\GF18290

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
InParanoidiB3LZQ9
KOiK11592
OMAiPKPDQPC
OrthoDBi1337630at2759
PhylomeDBiB3LZQ9

Gene expression databases

BgeeiFBgn0095308 Expressed in 1 organ(s), highest expression level in adult organism

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3LZQ9_DROAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3LZQ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 16, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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