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Protein

Lysophospholipase NTE1

Gene

SCRG_01839

Organism
Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.UniRule annotation

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1406NucleophilePROSITE-ProRule annotation1
Active sitei1524Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation
Biological processLipid degradationPROSITE-ProRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1UniRule annotation (EC:3.1.1.5UniRule annotation)
Alternative name(s):
Intracellular phospholipase BUniRule annotation
Gene namesi
ORF Names:SCRG_01839Imported
OrganismiSaccharomyces cerevisiae (strain RM11-1a) (Baker's yeast)Imported
Taxonomic identifieri285006 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000008335 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 70HelicalUniRule annotationAdd BLAST20
Transmembranei77 – 94HelicalUniRule annotationAdd BLAST18
Transmembranei106 – 124HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Structurei

3D structure databases

ProteinModelPortaliB3LLJ6
SMRiB3LLJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini814 – 947Cyclic nucleotide-bindingInterPro annotationAdd BLAST134
Domaini943 – 1074Cyclic nucleotide-bindingInterPro annotationAdd BLAST132
Domaini1373 – 1537PNPLAInterPro annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1377 – 1382GXGXXGPROSITE-ProRule annotation6
Motifi1404 – 1408GXSXGPROSITE-ProRule annotation5
Motifi1524 – 1526DGA/GPROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the NTE family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

OrthoDBiEOG092C0BAH

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 3 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit

Sequencei

Sequence statusi: Complete.

B3LLJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSMNCTTNN TNNTGQNTKN SLGSSFNSSN YTSYRFQTCL TDQIISEAQT
60 70 80 90 100
WSLSSLFNFS WVVSYFVMGA SRMIFRYGWY LATLSLLRIP KWIFFKLHHV
110 120 130 140 150
QFTLSFWLIL FALAVIVFVT YTIMKERILS QYKRLTPEFL PLENTGKSGS
160 170 180 190 200
SANINAASTQ SANAPPAIGS STTGASSIID SKKHSLKDGN ENETFLSSYL
210 220 230 240 250
DQFLSAIKIF GYLEKPVFHD LTKNMKTQKM DEGEILLLDS TIGFAIVVEG
260 270 280 290 300
TLQLYHEVDH SDKDHGDETD HSDTDGLDDQ DRDEEDEEED DDIDNYDTKS
310 320 330 340 350
CSSNLIDEED ESVGYIHLKN GLGNFQLLNT VKPGNPLTSL VSILNLFTHS
360 370 380 390 400
MSSYGNSNFP SELSSPIDTT VSVNNMFCSS EQNFSNTDSM TNSTNSFPTF
410 420 430 440 450
PSSMPKLVAR AATDCTIGII PPQSFAKLTA KYPRSASHII QMVLTKLYHV
460 470 480 490 500
TFQTAHDYLG LTKEIMDIEV LLNKSIVYEL PYYLKEAVIR KFKTVDKSSG
510 520 530 540 550
SADLEPKPKN SNASSKLKKP PKAKPSDGII QSLKIANANA NTSSNSLSLK
560 570 580 590 600
PEFTHHPSSR HVVLGSRDQF NPGDLLSNVP LSRTMDILSP NPIHNNNRNK
610 620 630 640 650
SNGINTSTSN QHKRSSRSSS NNASVHSKKF SSLSPELRNA QLSTSPLSLD
660 670 680 690 700
NTSVHDHIHP SPVHLKGRVS PRPNLLPTTS FSAAQEETED SALRMALVEA
710 720 730 740 750
MLTYLGVNKS NMSVSSSSIA NMSSLNSPQL NEMYSRRPSN ASFLMSPHCT
760 770 780 790 800
PSDISVASSF ASPQTQPTML RILPKEYTIS NKRHNKSKSQ DKKKPRAYKE
810 820 830 840 850
ELTPNLDFED VKKDFAQGIQ LKFFKKGTTI VEQNARGKGL FYIISGKVNV
860 870 880 890 900
TTNSSSSVVS SMSKPEQVSA QSSHKGENPH HTQHLLYSVG SGGIVGYLSS
910 920 930 940 950
LIGYKSFVNI VAKSDVYVGF LSSATLERLF DKYFLIYLRI SDSLTKLLSS
960 970 980 990 1000
RLLKLDHALE WVHLRASETL FSQGDSANGI YVVLNGRLRQ LQQQSLSNSN
1010 1020 1030 1040 1050
TSSEEVETQN IILGELAQGE SFGEVEVLTA MNRYSTIVAV RDSELARIPR
1060 1070 1080 1090 1100
TLFELLALEH PSIMIRVSRL VAKKIVGDRT VPALTGDPLS IKENDFTSLI
1110 1120 1130 1140 1150
PPTKASYSSS LSHKPQNITS GTITFRTITI LPITSGLPVE AFAMKLVQAF
1160 1170 1180 1190 1200
KQVGRTTIGL NQRTTLTHLG RHAFDRLSKL KQSGYFAELE EMYQTVVYIS
1210 1220 1230 1240 1250
DTPVKSNWTR TCIAQGDCIL LLADARSPSA EIGEYEKLLL NSKTTARTEL
1260 1270 1280 1290 1300
ILLHPERYVE PGLTHKWLRY RPWVHSHHHI QFSLTGTTLM NEGKMHVLNN
1310 1320 1330 1340 1350
GALALMDKLI QTEFSRKTQQ NISKLLPDSI KNTVENFSSR FMKSKRQYYT
1360 1370 1380 1390 1400
PVHRHKNDFL RLARILSGQA IGLVLGGGGA RGISHLGVIQ AIEEQGIPVD
1410 1420 1430 1440 1450
VIGGTSIGSF VGGLYAKDYD LVPIYGRVKK FAGRISSIWR MLTDLTWPVT
1460 1470 1480 1490 1500
SYTTGHEFNR GIWKTFGDTR IEDFWIQYYC NSTNITDSVQ EIHSFGYAWR
1510 1520 1530 1540 1550
YIRASMSLAG LLPPLEENGS MLLDGGYVDN LPVTEMRARG CQTIFAVDVG
1560 1570 1580 1590 1600
SADDRTPMEY GDSLNGFWII FNRWNPFSSH PNIPNMAEIQ VRLGYVASVN
1610 1620 1630 1640 1650
ALEKAKNTPG VVYVRPPIEE YATLDFSKFE EIYHVGVDYG RIFLQGLIDD
1660 1670
DKMPYIPGSQ ETTLNSQVPE FLLHRRNSI
Length:1,679
Mass (Da):187,133
Last modified:September 2, 2008 - v1
Checksum:i550FFCD4ACAF8E25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408047 Genomic DNA Translation: EDV11449.1

Genome annotation databases

EnsemblFungiiEDV11449; EDV11449; SCRG_01839

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408047 Genomic DNA Translation: EDV11449.1

3D structure databases

ProteinModelPortaliB3LLJ6
SMRiB3LLJ6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDV11449; EDV11449; SCRG_01839

Phylogenomic databases

OrthoDBiEOG092C0BAH

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 3 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB3LLJ6_YEAS1
AccessioniPrimary (citable) accession number: B3LLJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 7, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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