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Entry version 43 (31 Jul 2019)
Sequence version 1 (02 Sep 2008)
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Protein
Submitted name:

cDNA FLJ46662 fis, clone TRACH3006800, highly similar to Homo sapiens mucin 16, cell surface associated (MUC16), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ46662 fis, clone TRACH3006800, highly similar to Homo sapiens mucin 16, cell surface associated (MUC16), mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
B3KY81

PRoteomics IDEntifications database

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PRIDEi
B3KY81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
B3KY81 HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 103SEAInterPro annotationAdd BLAST103
Domaini138 – 259SEAInterPro annotationAdd BLAST122
Domaini294 – 415SEAInterPro annotationAdd BLAST122
Domaini428 – 549SEAInterPro annotationAdd BLAST122
Domaini584 – 705SEAInterPro annotationAdd BLAST122
Domaini740 – 861SEAInterPro annotationAdd BLAST122
Domaini896 – 1017SEAInterPro annotationAdd BLAST122
Domaini1030 – 1150SEAInterPro annotationAdd BLAST121
Domaini1163 – 1284SEAInterPro annotationAdd BLAST122
Domaini1314 – 1434SEAInterPro annotationAdd BLAST121
Domaini1439 – 1550SEAInterPro annotationAdd BLAST112
Domaini1560 – 1647SEAInterPro annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni554 – 580DisorderedSequence analysisAdd BLAST27
Regioni866 – 888DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi554 – 578PolarSequence analysisAdd BLAST25

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000203664

KEGG Orthology (KO)

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KOi
K16145

Database of Orthologous Groups

More...
OrthoDBi
98at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.960, 12 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028850 MUC16
IPR000082 SEA_dom
IPR036364 SEA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14672 PTHR14672, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01390 SEA, 12 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF82671 SSF82671, 12 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50024 SEA, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KY81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHPGSRKFN TTERVLQGLL KPLFKSTSVG PLYSGCRLTL LRPEKHGAAT
60 70 80 90 100
GVDAICTLRL DPTGPGLDRE WLYWELSQLT NSVTELGPYT LDRDSLYVNG
110 120 130 140 150
FTHRSSVPTT SIPGTSAVHL ETSGTPASLP GHTAPGPLLV PFTLNFTITN
160 170 180 190 200
LQYEEDMRHP GSRKFNTTER VLQGLLKPLF KSTSVGPLYS GCRLTLLRPE
210 220 230 240 250
KRGAATGVDT ICTHRLDPLN PGLDREQLYW ELSKLTHGII ELGPYLLDRG
260 270 280 290 300
SLYVNGFTHR NFVPITSTPG TSTVHLGTSE TPSSLPRPIV PGPLLVPFTL
310 320 330 340 350
NFTITNLQYE EAMRHPGSRK FNTTERVLQG LLRPLFKNTS IGPLYSSCRL
360 370 380 390 400
TLLRPEKDKA ATRVDAICTH HPDPQSPGLN REQLYWELSQ LTHGITELGP
410 420 430 440 450
YTLDRDSLYV DGFTHWSPIP TTSTTGPLLM PFTLNFTITN LQYEENMGHP
460 470 480 490 500
GSRKFNITES VLQGLLKPLF KSTSVGPLYS GCRLTLLRPE KDGVATRVDA
510 520 530 540 550
ICTHRPDPKI PGLDRQQLYW ELSQLTHSIT ELGPYTLDRD SLYVNGFTQR
560 570 580 590 600
SSVPTTSTPG TFTVQPETSE TPSSLPGPTA TGPVLLPFTL NFTITNLQYE
610 620 630 640 650
EDMHRPGSRK FNTTERVLQG LLMPLFKNTS VSSLYSGCRL TLLRPEKDGA
660 670 680 690 700
ATRVDAVCTH RPDPKSPGLD RERLYWKLSQ LTHGITELGP YTLDRHSLYV
710 720 730 740 750
NGFTHQSSMT TTRTPDTSTM HLATSRTPAS LSGPTTASPL LVLFTINFTI
760 770 780 790 800
TNLRYEENMH HPGSRKFNTT ERVLQGLLRP VFKNTSVGPL YSGCRLTLLR
810 820 830 840 850
PKKDGAATKV DAICTYRPDP KSPGLDREQL YWELSQLTHS ITELGPYTLD
860 870 880 890 900
RDSLYVNGFT QRSSVPTTSI PGTPTVDLGT SGTPVSKPGP SAASPLLVLF
910 920 930 940 950
TLNFTITNLR YEENMQHPGS RKFNTTERVL QGLLRSLFKS TSVGPLYSGC
960 970 980 990 1000
RLTLLRPEKD GTATGVDAIC THHPDPKSPR LDREQLYWEL SQLTHNITEL
1010 1020 1030 1040 1050
GPYALDNDSL FVNGFTHRSS VSTTSTASHL LILFTLNFTI TNLRYEENMW
1060 1070 1080 1090 1100
PGSRKFNTTE RVLQGLLRPL FKNTSVGPLY SGCRLTLLRP EKDGEATGVD
1110 1120 1130 1140 1150
AICTHRPDPT GPGLDREQLY LELSQLTHSI TELGPYTLDR DSLYVNGFTH
1160 1170 1180 1190 1200
RSSVPTTSTG VVSEEPFTLN FTINNLRYMA DMGQPGSLKF NITDNVMKHL
1210 1220 1230 1240 1250
LSPLFQRSSL GARYTGCRVI ALRSVKNGAE TRVDLLCTYL QPLSGPGLPI
1260 1270 1280 1290 1300
KQVFHELSQQ THGITRLGPY SLDKDSLYLN GYNEPGPDEP PTTPKPATTF
1310 1320 1330 1340 1350
LPPLSEATTA MGYHLKTLTL NFTISNLQYS PDMGKGSATF NSTEGVLQHL
1360 1370 1380 1390 1400
LRPLFQKSSM GPFYLGCQLI SLRPEKDGAA TGVDTTCTYH PDPVGPGLDI
1410 1420 1430 1440 1450
QQLYWELSQL THGVTQLGFY VLDRDSLFIN GYAPQNLSIR GEYQINFHIV
1460 1470 1480 1490 1500
NWNLSNPDPT SSEYITLLRD IQDKVTTLYK GSQLHDTFRF CLVTNLTMDS
1510 1520 1530 1540 1550
VLVTVKALFS SNLDPSLVEQ VFLDKTLNAS FHWLGSTYQL VDIHVTEMES
1560 1570 1580 1590 1600
SVYQPTSSSS TQHFYLNFTI TNLPYSQDKA QPGTTNYQRN KRNIEDAVRR
1610 1620 1630 1640
GCSTNSSETA ASRVIFLTVK FQHSGLSPTG TTPGWTPCVT SRHWLGE
Length:1,647
Mass (Da):182,991
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD09D2739F82B4899
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK128857 mRNA Translation: BAG54743.1

NCBI Reference Sequences

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RefSeqi
NP_078966.2, NM_024690.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
94025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:94025

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128857 mRNA Translation: BAG54743.1
RefSeqiNP_078966.2, NM_024690.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB3KY81
PRIDEiB3KY81

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi94025
KEGGihsa:94025

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94025

Phylogenomic databases

HOGENOMiHOG000203664
KOiK16145
OrthoDBi98at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
94025

Gene expression databases

GenevisibleiB3KY81 HS

Family and domain databases

Gene3Di3.30.70.960, 12 hits
InterProiView protein in InterPro
IPR028850 MUC16
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PANTHERiPTHR14672 PTHR14672, 5 hits
PfamiView protein in Pfam
PF01390 SEA, 12 hits
SUPFAMiSSF82671 SSF82671, 12 hits
PROSITEiView protein in PROSITE
PS50024 SEA, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KY81_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KY81
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 31, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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