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Entry version 67 (02 Dec 2020)
Sequence version 1 (02 Sep 2008)
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Protein

Condensin complex subunit 1

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA condensationUniRule annotationARBA annotation, MitosisUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Condensin complex subunit 1UniRule annotationARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeARBA annotation, NucleusARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B3KY03

PRoteomics IDEntifications database

More...
PRIDEi
B3KY03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B3KY03, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 201Cnd1_NInterPro annotationAdd BLAST118
Domaini1031 – 1191Cnd1InterPro annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni537 – 572DisorderedSequence analysisAdd BLAST36
Regioni917 – 939DisorderedSequence analysisAdd BLAST23
Regioni1264 – 1362DisorderedSequence analysisAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili411 – 431Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi539 – 562PolarSequence analysisAdd BLAST24
Compositional biasi917 – 936PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1285 – 1300PolarSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CND1 (condensin subunit 1) family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
166920at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR026971, CND1/NCAPD3
IPR032682, Cnd1_C
IPR007673, Condensin_cplx_su1
IPR024324, Condensin_cplx_su1_N

The PANTHER Classification System

More...
PANTHERi
PTHR14222, PTHR14222, 1 hit
PTHR14222:SF2, PTHR14222:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12717, Cnd1, 1 hit
PF12922, Cnd1_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017127, Condensin_D2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KY03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPQMYEFHL PLSPEELLKS GGVNQYVVQE VLSIKHLPPQ LRAFQAAFRA
60 70 80 90 100
QGPLAMLQHF DTIYSILHHF RSIDPGLKED TLQFLIRLLE SFETMASQTN
110 120 130 140 150
LVDLDLGGKG KKARTKAAHG FDWEEERQPI LQLLTQLLQL DIRHLWNHSI
160 170 180 190 200
IEEEFVSLVT GCCYRLLENP TINHQKNRPT REAITHLLGV ALTRYNHMLS
210 220 230 240 250
ATVKIIQMLQ HFEHLAPVLV AAVSLWATDY GMKSIVGEIV REIGQKCPQE
260 270 280 290 300
LSRDPSGTKG FAAFLTELAE RVPAILMSSM CILLDHLDGE NYMMRNAVLA
310 320 330 340 350
AMAEMVLQVL SGDQLEAAAR DTRDQFLDTL QAHGHDVNSF VRSRVLQLFT
360 370 380 390 400
RIVQQKALPL TRFQAVVALA VGRLADKSVL VCKNAIQLLA SFLANNPFSC
410 420 430 440 450
KLSDADLAGP LQKETQKLQE MRAQRRTAAA SAVLDPEEEW EAMLPELKST
460 470 480 490 500
LQQLLQLPQG EEEIPEQIAN TETTEDVKGR IYQLLAKASY KKAIILTREA
510 520 530 540 550
TGHFQESEPF SHIDPEESEE TRLLNILGLI FKGPAASTQE KNPRESTGNM
560 570 580 590 600
VTGQTVCKNK PNMSDPEESR GNDELVKQEM LVQYLQDAYS FSRKITEAIG
610 620 630 640 650
IISKMMYENT TTVVQEVIEF FVMVFQFGVP QALFGVRRML PLIWSKEPGV
660 670 680 690 700
REAVLNAYRQ LYLNPKGDSA RAKAQALIQN LSLLLVDASV GTIQCLEEIL
710 720 730 740 750
CEFVQKDELK PAVTQLLWER ATEKVACCPL ERCSSVMLLG MMARGKPEIV
760 770 780 790 800
GSNLDTLVSI GLDENFPQDY RLAQQVCHAI ANISDRRKPS LGKRHPPFRL
810 820 830 840 850
PQEHRLFERL RETVTKGFVH PDPLWIPFKE VAVTLIYQLA EGPEVICAQI
860 870 880 890 900
LQGCAKQALE KLEEKRTSQE DPKESPAMLP TFLLMNLLSL AGDVALQQLV
910 920 930 940 950
HLEQAVSGEL CRRRVLREEQ EHKTKDPKEK NTSSETTMEE ELGLVGATAD
960 970 980 990 1000
DTEAELIRGI CEMELLDGKQ TLAAFVPLLL KVCNNPGLYS NPDLSAAASL
1010 1020 1030 1040 1050
ALGKFCMISA TFCDSQLRLL FTMLEKSPLP IVRSNLMVAT GDLAIRFPNL
1060 1070 1080 1090 1100
VDPWTPHLYA RLRDPAQQVR KTAGLVMTHL ILKDMVKVKG QVSEMAVLLI
1110 1120 1130 1140 1150
DPEPQIAALA KNFFNELSHK GNAIYNLLPD IISRLSDPEL GVEEEPFHTI
1160 1170 1180 1190 1200
MKQLLSYITK DKQTESLVEK LCQRFRTSRT ERQQRDLAYC VSQLPLTERG
1210 1220 1230 1240 1250
LRKMLDNFDC FGDKLSDESI FSAFLSVVGK LRRGAKPEGK AIIDEFEQKL
1260 1270 1280 1290 1300
RACHTRGLDG IKELEIGQAG SQRAPSAKKP SAGSRYQPLA STASDNDFVT
1310 1320 1330 1340 1350
PEPRRTTRRH PNTQQRASKK KPKVVFSSDE SSEEDLSAEM TEDETPKKTT
1360
PILRASARRH RS
Length:1,362
Mass (Da):152,860
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i849AF9CF2D95B1A7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK128354 mRNA Translation: BAG54665.1

NCBI Reference Sequences

More...
RefSeqi
NP_055680.3, NM_014865.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9918

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9918

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128354 mRNA Translation: BAG54665.1
RefSeqiNP_055680.3, NM_014865.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB3KY03
PRIDEiB3KY03

Genome annotation databases

GeneIDi9918
KEGGihsa:9918

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9918
PharmGKBiPA162397021

Phylogenomic databases

OrthoDBi166920at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9918, 591 hits in 850 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9918

Gene expression databases

GenevisibleiB3KY03, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR026971, CND1/NCAPD3
IPR032682, Cnd1_C
IPR007673, Condensin_cplx_su1
IPR024324, Condensin_cplx_su1_N
PANTHERiPTHR14222, PTHR14222, 1 hit
PTHR14222:SF2, PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717, Cnd1, 1 hit
PF12922, Cnd1_N, 1 hit
PIRSFiPIRSF017127, Condensin_D2, 2 hits
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KY03_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KY03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: December 2, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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