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Entry version 70 (19 Jan 2022)
Sequence version 1 (02 Sep 2008)
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Protein

Structural maintenance of chromosomes protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycleARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structural maintenance of chromosomes proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

ChromosomeARBA annotation, NucleusUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B3KXX5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini588 – 703SMC hingeInterPro annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45DisorderedSequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili302 – 350Sequence analysisAdd BLAST49
Coiled coili372 – 406Sequence analysisAdd BLAST35
Coiled coili414 – 459Sequence analysisAdd BLAST46
Coiled coili467 – 487Sequence analysisAdd BLAST21
Coiled coili492 – 512Sequence analysisAdd BLAST21
Coiled coili516 – 550Sequence analysisAdd BLAST35
Coiled coili744 – 820Sequence analysisAdd BLAST77
Coiled coili874 – 985Sequence analysisAdd BLAST112
Coiled coili1085 – 1105Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 28Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family. SMC4 subfamily.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03274, ABC_SMC4_euk, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR024704, SMC
IPR041738, SMC4_ABC_euk
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06470, SMC_hinge, 1 hit
PF02463, SMC_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005719, SMC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00968, SMC_hinge, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF75553, SSF75553, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KXX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRKGTQPST ARRREEGPPP PSPDGASSDA EPEPPSGRTE SPATAAAMTN
60 70 80 90 100
EAGAPRLMIT HIVNQNFKSY AGEKILGPFH KRFSCIIGPN GSGKSNVIDS
110 120 130 140 150
MLFVFGYRAQ KIRSKKLSVL IHNSDEHKDI QSCTVEVHFQ KIIDKEGDDY
160 170 180 190 200
EVIPNSNFYV SRTACRDNTS VYHISGKKKT FKDVGNLLRS HGIDLDHNRF
210 220 230 240 250
LILQGEVEQI AMMKPKGQTE HDEGMLEYLE DIIGCGRLNE PIKVLCRRVE
260 270 280 290 300
ILNEHRGEKL NRVKMVEKEK DALEGEKNIA IEFLTLENEI FRKKNHVCQY
310 320 330 340 350
YIYELQKRIA EMETQKEKIH EDTKEINEKS NILSNEMKAK NKDVKDTEKK
360 370 380 390 400
LNKITKFIEE NKEKFTQLDL EDVQVREKLK HATSKAKKLE KQLQKDKEKV
410 420 430 440 450
EEFKSIPAKS NNIINETTTR NNALEKEKEK EEKKLKEVMD SLKQETQGLQ
460 470 480 490 500
KEKESREKEL MGFSKSVNEA RSKMDVAQSE LDIYLSRHNT AVSQLTKAKE
510 520 530 540 550
ALIAASETLK ERKAAIRDIE GKLPQTEQEL KEKEKELQKL TQEETNFKSL
560 570 580 590 600
VHDLFQKVEE AKSSLAMNRS RGKVLDAIIQ EKKSGRIPGI YGRLGDLGAI
610 620 630 640 650
DEKYDVAISS CCHALDYIVV DSIDIAQECV NFLKRQNIGV ATFIGLDKMA
660 670 680 690 700
VWAKKMTEIQ TPENTPRLFD LVKVKDEKIR QAFYFALRDT LVADNLDQAT
710 720 730 740 750
RVAYQKDRRW RVVTLQGQII EQSGTMTGGG SKVMKGRMGS SLVIEISEEE
760 770 780 790 800
VNKMESQLQN DSKKAMQIQE QKVQLEERVV KLRHSEREMR NTLEKFTASI
810 820 830 840 850
QRLIEQEEYL NVQVKELEAN VLATAPDKKK QKLLEENVSA FKTEYDAVAE
860 870 880 890 900
KAGKVEAEVK RLHNTIVEIN NHKLKAQQDK LDKINKQLDE CASAITKAQV
910 920 930 940 950
AIKTADRDLQ KAQDSVLRTE KEIKDTEKEV DDLTAELKSL EDKAAEVVKN
960 970 980 990 1000
TNAAEESLPE IQKEHRNLLQ ELKVIQENEH ALQKDALSIK LKLEQIDGHI
1010 1020 1030 1040 1050
AEHNSKIKYW HKEISKISLH PIEDNPIEEI SVLSPEDLEA IKNPDSITNQ
1060 1070 1080 1090 1100
IALLEARCHE MKPNLGAIAE YKKKEELYLQ RVAELDKITY ERDSFRQAYE
1110 1120 1130 1140 1150
DLRKQRLNEF MAGFYIITNK LKENYQMLTL GGDAELELVD SLDPFSEGIM
1160 1170 1180 1190 1200
FSVRPPKKSW KKIFNLSGGE KTLSSLALVF ALHHYKPTPL YFMDEIDAAL
1210 1220 1230 1240 1250
DFKNVSIVAF YIYEQTKNAQ FIIISLRNNM FEISDRLIGI YKTYNITKSV
1260
AVNPKEIASK GLC
Length:1,263
Mass (Da):144,456
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1669A9A30E00866
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK128143 mRNA Translation: BAG54637.1

NCBI Reference Sequences

More...
RefSeqi
NP_001275682.1, NM_001288753.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10051

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128143 mRNA Translation: BAG54637.1
RefSeqiNP_001275682.1, NM_001288753.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB3KXX5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10051

Genome annotation databases

GeneIDi10051

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10051

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10051, 787 hits in 1055 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10051

Family and domain databases

CDDicd03274, ABC_SMC4_euk, 2 hits
Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR024704, SMC
IPR041738, SMC4_ABC_euk
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf
PfamiView protein in Pfam
PF06470, SMC_hinge, 1 hit
PF02463, SMC_N, 1 hit
PIRSFiPIRSF005719, SMC, 1 hit
SMARTiView protein in SMART
SM00968, SMC_hinge, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF75553, SSF75553, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KXX5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KXX5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 19, 2022
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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