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Entry version 76 (02 Dec 2020)
Sequence version 1 (02 Sep 2008)
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Protein
Submitted name:

cDNA FLJ45892 fis, clone OCBBF3023175, highly similar to Protein neurobeachin

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
B3KXQ8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ45892 fis, clone OCBBF3023175, highly similar to Protein neurobeachinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

MembraneARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500279042119 – 1558Sequence analysisAdd BLAST1540

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B3KXQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B3KXQ8, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini759 – 867BEACH-type PHInterPro annotationAdd BLAST109
Domaini886 – 1175BEACHInterPro annotationAdd BLAST290
Domaini1470 – 1553WD_REPEATS_REGIONInterPro annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni102 – 143DisorderedSequence analysisAdd BLAST42
Regioni263 – 287DisorderedSequence analysisAdd BLAST25
Regioni322 – 343DisorderedSequence analysisAdd BLAST22
Regioni453 – 472DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi112 – 136PolarSequence analysisAdd BLAST25

Keywords - Domaini

SignalSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
153369at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06071, Beach, 1 hit
cd01201, PH_BEACH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000409, BEACH_dom
IPR036372, BEACH_dom_sf
IPR010508, DUF1088
IPR023362, PH-BEACH_dom
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02138, Beach, 1 hit
PF06469, DUF1088, 1 hit
PF14844, PH_BEACH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01026, Beach, 1 hit
SM00320, WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit
SSF81837, SSF81837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50197, BEACH, 1 hit
PS51783, PH_BEACH, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KXQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDNIIIACG GILPLLSAAT SPTGSKTELE NIEVTQGMSA ETAVTFLSRL
60 70 80 90 100
MAMVDVLVFA SSLNFSEIEA EKNMSSGGLM RQCLRLVCCV AVRNCLECRQ
110 120 130 140 150
RQRDRGNKSS HGSSKPQEVP QSVTATAASK TPLENVPGNL SPIKDPDRLL
160 170 180 190 200
QDVDINRLRA VVFRDVDDSK QAQFLALAVV YFISVLMVSK YRDILEPQRE
210 220 230 240 250
TTRTGSQPGR NIRQEINSPT STVVVIPSIP HPSLNHGFLA KLIPEQSFGH
260 270 280 290 300
SFYKETPAAF PDTIKEKETP TPGEDIQVES SIPHTDSGIG EEQVASILNG
310 320 330 340 350
AELETSTGPD AMSELLSTLS SEVKKSQESL TENPSETLKP ATSISSISQT
360 370 380 390 400
KGINVKEILK SLVAAPVEIA ECGPEPIPYP DPALKRETQA ILPMQFHSFD
410 420 430 440 450
RSVVVPVKKP PPGSLAVTTV GATTAGSGLP TGSTSNIFAA TGATPKSMIN
460 470 480 490 500
TTGAVDSGSS SSSSSSSFVN GATSKNLPAV QTVAPMPEDS AENMSITAKL
510 520 530 540 550
ERALEKVAPL LREIFVDFAP FLSRTLLGSH GQELLIEGLV CMKSSTSVVE
560 570 580 590 600
LVMLLCSQEW QNSIQKNAGL AFIELINEGR LLCHAMKDHI VRVANEAEFI
610 620 630 640 650
LNRQRAEDVH KHAEFESQCA QYAADRREEE KMCDHLISAA KHRDHVTANQ
660 670 680 690 700
LKQKILNILT NKHGAWGAVS HSQLHDFWRL DYWEDDLRRR RRFVRNAFGS
710 720 730 740 750
THAEALLKAA IEYGTEEDVV KSKKTFRSQA IVNQNAETEL MLEGDDDAVS
760 770 780 790 800
LLQEKEIDNL AGPVVLSTPA QLIAPVVVAK GTLSITTTEI YFEVDEDDSA
810 820 830 840 850
FKKIDTKVLA YTEGLHGKWM FSEIRAVFSR RYLLQNTALE VFMANRTSVM
860 870 880 890 900
FNFPGQATVK KVVYSLPRVG VGTSYGLPQA RRISLATPRQ LYKSSNMTQR
910 920 930 940 950
WQRREISNFE YLMFLNTIAG RTYNDLNQYP VFPWVLTNYE SEELDLTLPG
960 970 980 990 1000
NFRDLSKPIG ALNPKRAVFY AERYETWEDD QSPPYHYNTH YSTATSTLSW
1010 1020 1030 1040 1050
LVRIEPFTTF FLNANDGKFD HPDRTFSSVA RSWRTSQRDT SDVKELIPEF
1060 1070 1080 1090 1100
YYLPEMFVNS NGYNLGVRED EVVVNDVDLP PWAKKPEDFV RINRMALESE
1110 1120 1130 1140 1150
FVSCQLHQWI DLIFGYKQRG PEAVRALNVF HYLTYEGSVN LDSITDPVLR
1160 1170 1180 1190 1200
EAMEAQIQNF GQTPSQLLIE PHPPRSSAMH LCFLPQSPLM FKDQMQQDVI
1210 1220 1230 1240 1250
MVLKFPSNSP VTHVAANTLP HLTIPAVVTV TCSRLFAVNR WHNTVGLRGA
1260 1270 1280 1290 1300
PGYSLDQAHH LPIEMDPLIA NNSGVNKRQI TDLVDQSIQI NAHCFVVTAD
1310 1320 1330 1340 1350
NRYILICGFW DKSFRVYSTE TGKLTQIVFG HWDVVTCLAR SESYIGGDCY
1360 1370 1380 1390 1400
IVSGSRDATL LLWYWSGRHH IIGDNPNSSD YPAPRAVLTG YDHEVVCVSV
1410 1420 1430 1440 1450
CAELGLVISG AKEGPCLVHT ITGDLLRALE GPENCLFPRL ISVSSEGHCI
1460 1470 1480 1490 1500
IYYERGRFSN FSINGKLLAQ MEINDSTRAI LLSSDGQNLV TGGDNGVVEV
1510 1520 1530 1540 1550
WQACDFKQLY IYPGCDAGIR AMDLSHDQRT LITGMASGSI VAFNIDFNRW

HYEHQNRY
Length:1,558
Mass (Da):173,087
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77F416F15A881CB4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK127791 mRNA Translation: BAG54570.1

NCBI Reference Sequences

More...
RefSeqi
NP_056493.3, NM_015678.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127791 mRNA Translation: BAG54570.1
RefSeqiNP_056493.3, NM_015678.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB3KXQ8

Genome annotation databases

GeneIDi26960
KEGGihsa:26960

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26960
PharmGKBiPA31454

Phylogenomic databases

OrthoDBi153369at2759

Enzyme and pathway databases

SignaLinkiB3KXQ8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
26960, 4 hits in 843 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26960

Gene expression databases

GenevisibleiB3KXQ8, HS

Family and domain databases

CDDicd06071, Beach, 1 hit
cd01201, PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
InterProiView protein in InterPro
IPR000409, BEACH_dom
IPR036372, BEACH_dom_sf
IPR010508, DUF1088
IPR023362, PH-BEACH_dom
IPR001680, WD40_repeat
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138, Beach, 1 hit
PF06469, DUF1088, 1 hit
PF14844, PH_BEACH, 1 hit
SMARTiView protein in SMART
SM01026, Beach, 1 hit
SM00320, WD40, 5 hits
SUPFAMiSSF50978, SSF50978, 1 hit
SSF81837, SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197, BEACH, 1 hit
PS51783, PH_BEACH, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KXQ8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KXQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: December 2, 2020
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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