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UniProtKB - B3KXA2 (B3KXA2_HUMAN)

Entry version 64 (07 Apr 2021)
Sequence version 1 (02 Sep 2008)
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Protein

Metavinculin

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MetavinculinARBA annotation
Alternative name(s):
VinculinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junctionARBA annotation, Cell membraneARBA annotation, CytoplasmARBA annotation, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37288

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		B3KXA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		B3KXA2, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni784 – 814DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili287 – 314Sequence analysisAdd BLAST28
Coiled coili500 – 520Sequence analysisAdd BLAST21
Coiled coili951 – 974Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi786 – 800Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		270073at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR017997, Vinculin
IPR006077, Vinculin/catenin
IPR000633, Vinculin_CS

The PANTHER Classification System

More...PANTHERi		PTHR46180, PTHR46180, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01044, Vinculin, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47220, SSF47220, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00663, VINCULIN_1, 1 hit
PS00664, VINCULIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KXA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPAFIKVEN ACTKLVQAAQ MLQSDPYSVP ARDYLIDGSR GILSGTSDLL 
        60         70         80         90        100
LTFDEAEVRK IIRVCKGILE YLTVAEVVET MEDLVTYTKN LGPGMTKMAK 
       110        120        130        140        150
MIDERQQELT HQEHRVMLVN SMNTVKELLP VLISAMKIFV TTKNSKNQGI 
       160        170        180        190        200
EEALKNRNFT VEKMSAEINE IIRVLQLTSW DEDAWASKDT EAMKRALASI 
       210        220        230        240        250
DSKLNQAKGW LRDPSASPGD AGEQAIRQIL DEAGKVGELC AGKERREILG 
       260        270        280        290        300
TCKMLEQMTD QVADLRARGQ GSSPVAMQKA QQVSQGLDVL TAKVENAARK 
       310        320        330        340        350
LEAMTNSKQS IAKKIDAAQN WLADPNGGPE GEEQIRGALA EARKIAELCD 
       360        370        380        390        400
DPKERDDILR SLGEISALTS KLADLRRQGK GDSPEARALA KQVATALQNL 
       410        420        430        440        450
QTKTNRAVAN SRPAKAAVHL EGKIEQAQRW IDNPTVDDRG VGQAAIRGLV 
       460        470        480        490        500
AEGHRLANVM MGPYRQDLLA KCDRVDQLTA QLADLAARGE GESPQARALA 
       510        520        530        540        550
SQLQDSLKDL KARMQEAMTQ EVSDVFSDTT TPIKLLAVAA TAPPDAPNRE 
       560        570        580        590        600
EVFDERAANF ENHSGKLGAT AEKAAAVGTA NKSTVEGIQA SVKTARELTP 
       610        620        630        640        650
QVVSAARILL RNPGNQAAYE HFETMKNQWI DNVEKMTGLV DEAIDTKSLL 
       660        670        680        690        700
DASEEAIKKD LDKCKVAMAN IQPQMLVAGA TSIARRANRI LLAAKREVEN 
       710        720        730        740        750
SEDPKFREAV KAASDELSKT ISPMVMDAKA VAGNISDPGL QKSFLDSGYR 
       760        770        780        790        800
ILGAVAKVRE AFQPQEPDFP PPPPDLEQLR LTDELAPPKP PLPEGEVPPP 
       810        820        830        840        850
RPPPPEEKDE EFPEQKAGEV INQPMMMAAR QLHDEARKWS SKGNDIIAAA 
       860        870        880        890        900
KRMALLMAEM SRLVRGGSGT KRALIQCAKD IAKASDEVTR LAKEVAKQCT 
       910        920        930        940        950
DKRIRTNLLQ VCERIPTIST QLKILSTVKA TMLGRTNISD EESEQATEML 
       960        970        980        990       1000
VHNAQNLMQS VKETVRELKL LQSKFEQMLD LHCAGLERLP GTSRHLAEPG 

WHRNLY
Length:1,006
Mass (Da):110,306
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA2C56F9404FF44C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK126978 mRNA Translation: BAG54414.1

NCBI Reference Sequences

More...RefSeqi		NP_003364.1, NM_003373.3
NP_054706.1, NM_014000.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7414

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7414

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126978 mRNA Translation: BAG54414.1
RefSeqiNP_003364.1, NM_003373.3
NP_054706.1, NM_014000.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiB3KXA2

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7414

Genome annotation databases

GeneIDi7414
KEGGihsa:7414

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7414
PharmGKBiPA37288

Phylogenomic databases

OrthoDBi270073at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7414, 113 hits in 991 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7414

Gene expression databases

GenevisibleiB3KXA2, HS

Family and domain databases

InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR017997, Vinculin
IPR006077, Vinculin/catenin
IPR000633, Vinculin_CS
PANTHERiPTHR46180, PTHR46180, 1 hit
PfamiView protein in Pfam
PF01044, Vinculin, 2 hits
SUPFAMiSSF47220, SSF47220, 6 hits
PROSITEiView protein in PROSITE
PS00663, VINCULIN_1, 1 hit
PS00664, VINCULIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KXA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KXA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 7, 2021
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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