Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 86 (11 Dec 2019)
Sequence version 1 (02 Sep 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

cDNA FLJ44500 fis, clone UTERU3000828, highly similar to 116 kDa U5 small nuclear ribonucleoprotein component

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoproteinImported, Viral nucleoproteinImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ44500 fis, clone UTERU3000828, highly similar to 116 kDa U5 small nuclear ribonucleoprotein componentImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Virion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA142671915

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Proteomic databases

    PeptideAtlas

    More...
    PeptideAtlasi
    B3KX19

    PRoteomics IDEntifications database

    More...
    PRIDEi
    B3KX19

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    B3KX19 HS

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini117 – 399Tr-type GInterPro annotationAdd BLAST283

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 53DisorderedSequence analysisAdd BLAST53

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 49AcidicSequence analysisAdd BLAST36

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0469 Eukaryota
    COG0480 LUCA

    Database of Orthologous Groups

    More...
    OrthoDBi
    140796at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd04098 eEF2_C_snRNP, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.230.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR041095 EFG_II
    IPR035647 EFG_III/V
    IPR000640 EFG_V-like
    IPR004161 EFTu-like_2
    IPR031950 EFTUD2_N
    IPR027417 P-loop_NTPase
    IPR020568 Ribosomal_S5_D2-typ_fold
    IPR014721 Ribosomal_S5_D2-typ_fold_subgr
    IPR005225 Small_GTP-bd_dom
    IPR000795 TF_GTP-bd_dom
    IPR009000 Transl_B-barrel_sf
    IPR005517 Transl_elong_EFG/EF2_IV
    IPR035655 U5-116kDa_C

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00679 EFG_C, 1 hit
    PF14492 EFG_II, 1 hit
    PF03764 EFG_IV, 1 hit
    PF16004 EFTUD2, 1 hit
    PF00009 GTP_EFTU, 1 hit
    PF03144 GTP_EFTU_D2, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00315 ELONGATNFCT

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00838 EFG_C, 1 hit
    SM00889 EFG_IV, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF50447 SSF50447, 1 hit
    SSF52540 SSF52540, 1 hit
    SSF54211 SSF54211, 1 hit
    SSF54980 SSF54980, 2 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00231 small_GTP, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51722 G_TR_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    B3KX19-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDTDLYDEFG NYIGPELDSD EDDDELGRET KDLDEMDDDD DDDDVGDHDD
    60 70 80 90 100
    DHPGMEVVLH EVYGPEVETI VQEEDTQPLT EPIIKPVKTK KFTLMEQTLP
    110 120 130 140 150
    VTVYEMDFLA DLMDNSELIR NVTLCGHLHH GKTCFVDCLI EQTHPEIRKR
    160 170 180 190 200
    YDQDLCYTDI LFTEQERGVG IKSTPVTVVL PDTKGKSYLF NIMDTPGHVN
    210 220 230 240 250
    FSDEVTAGLR ISDGVVLFID AAEGVMLNTE RLIKHAVQER LAVTVCINKI
    260 270 280 290 300
    DRLILELKLP PTDAYYKLRH IVDEVNGLIS MYSTDENLIL SPLLGNVCFS
    310 320 330 340 350
    SSQYSICFTL GSFAKIYADT FGDINYQEFA KRLWGDIYFN PKTRKFTKKA
    360 370 380 390 400
    PTSSSQRSFV EFILEPLYKI LAQVVGDVDT SLPRTLDELG IHLTKEELKL
    410 420 430 440 450
    NIRPLLRLVC KKFFGEFTGF VDMCVQHIPS PKVGAKPKIE HTYTGGVDSD
    460 470 480 490 500
    LGEAMSDCDP DGPLMCHTTK MYSTDDGVQF HAFGRVLSGT IHAGQPVKVL
    510 520 530 540 550
    GENYTLEDEE DSQICTVGRL WISVARYHIE VNRVPAGNWV LIEGVDQPIV
    560 570 580 590 600
    KTATITEPRG NEEAQIFRPL KFNTTSVIKI AVEPVNPSEL PKMLDGLRKV
    610 620 630 640 650
    NKSYPSLTTK VEESGEHVIL GTGELYLDCV MHDLRKMYSE IDIKVADPVV
    660 670 680 690 700
    TFCETVVETS SLKCFAETPN KKNKITMIAE PLEKGLAEDI ENEVVQITWN
    710 720 730 740 750
    RKKLGEFFQT KYDWDLLAAR SIWAFGPDAT GPNILVDDTL PSEVDKALLG
    760 770 780 790 800
    SVKDSIVQGF QWGTREGPLC DELIRNVKFK ILDAVVAQEP LHRGGGQIIP
    810 820 830 840 850
    TARRVVYSAF LMATPRLMEP YYFVEVQAPA DCVSAVYTVL ARRRGHVTQD
    860 870 880 890 900
    APIPGSPLYT IKAFIPAIDS FGFETDLRTH TQGQAFSLSV FHHWQIVPGD
    910 920 930 940 950
    PLDKSIVIRP LEPQPAPHLA REFMIKTRRR KGLSEDVSIS KFFDDPMLLE
    960
    LAKQDVVLNY PM
    Length:962
    Mass (Da):108,210
    Last modified:September 2, 2008 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F20F10787BA194F
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK126464 mRNA Translation: BAG54331.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001136077.1, NM_001142605.1
    NP_004238.3, NM_004247.3

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    9343

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK126464 mRNA Translation: BAG54331.1
    RefSeqiNP_001136077.1, NM_001142605.1
    NP_004238.3, NM_004247.3

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Proteomic databases

    PeptideAtlasiB3KX19
    PRIDEiB3KX19

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    9343

    Genome annotation databases

    GeneIDi9343

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9343
    PharmGKBiPA142671915

    Phylogenomic databases

    eggNOGiKOG0469 Eukaryota
    COG0480 LUCA
    OrthoDBi140796at2759

    Miscellaneous databases

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    9343

    Gene expression databases

    GenevisibleiB3KX19 HS

    Family and domain databases

    CDDicd04098 eEF2_C_snRNP, 1 hit
    Gene3Di3.30.230.10, 1 hit
    InterProiView protein in InterPro
    IPR041095 EFG_II
    IPR035647 EFG_III/V
    IPR000640 EFG_V-like
    IPR004161 EFTu-like_2
    IPR031950 EFTUD2_N
    IPR027417 P-loop_NTPase
    IPR020568 Ribosomal_S5_D2-typ_fold
    IPR014721 Ribosomal_S5_D2-typ_fold_subgr
    IPR005225 Small_GTP-bd_dom
    IPR000795 TF_GTP-bd_dom
    IPR009000 Transl_B-barrel_sf
    IPR005517 Transl_elong_EFG/EF2_IV
    IPR035655 U5-116kDa_C
    PfamiView protein in Pfam
    PF00679 EFG_C, 1 hit
    PF14492 EFG_II, 1 hit
    PF03764 EFG_IV, 1 hit
    PF16004 EFTUD2, 1 hit
    PF00009 GTP_EFTU, 1 hit
    PF03144 GTP_EFTU_D2, 1 hit
    PRINTSiPR00315 ELONGATNFCT
    SMARTiView protein in SMART
    SM00838 EFG_C, 1 hit
    SM00889 EFG_IV, 1 hit
    SUPFAMiSSF50447 SSF50447, 1 hit
    SSF52540 SSF52540, 1 hit
    SSF54211 SSF54211, 1 hit
    SSF54980 SSF54980, 2 hits
    TIGRFAMsiTIGR00231 small_GTP, 1 hit
    PROSITEiView protein in PROSITE
    PS51722 G_TR_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KX19_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KX19
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: December 11, 2019
    This is version 86 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again