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Entry version 83 (07 Apr 2021)
Sequence version 1 (02 Sep 2008)
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Protein
Submitted name:

cDNA FLJ43069 fis, clone BRTHA3009037, highly similar to Regulator of G-protein signaling 3

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ43069 fis, clone BRTHA3009037, highly similar to Regulator of G-protein signaling 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34374

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500278868729 – 1088Sequence analysisAdd BLAST1060

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B3KWG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B3KWG8, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 129C2InterPro annotationAdd BLAST84
Domaini189 – 266PDZInterPro annotationAdd BLAST78
Domaini963 – 1079RGSInterPro annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni559 – 823DisorderedSequence analysisAdd BLAST265
Regioni897 – 916DisorderedSequence analysisAdd BLAST20
Regioni922 – 946DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi570 – 587PolyampholyteSequence analysisAdd BLAST18
Compositional biasi600 – 614Pro-richSequence analysisAdd BLAST15
Compositional biasi615 – 640PolarSequence analysisAdd BLAST26
Compositional biasi643 – 667Pro-richSequence analysisAdd BLAST25
Compositional biasi766 – 796AcidicSequence analysisAdd BLAST31
Compositional biasi898 – 916PolyampholyteSequence analysisAdd BLAST19

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08713, RGS_RGS3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.196.10, 2 hits
2.30.29.30, 1 hit
2.30.42.10, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR016137, RGS
IPR034951, RGS_RGS3
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF00595, PDZ, 1 hit
PF00615, RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301, RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00228, PDZ, 1 hit
SM00315, RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50106, PDZ, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KWG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRTGFCCFT VSLFVWMDMS MCVSLSRCVC VYVSIHPPQC LNSLLVIEGK
60 70 80 90 100
GLISKQPGTC DPYVKISLIP EDSRLRHQKT QTVPDCRDPA FHEHFFFPVQ
110 120 130 140 150
EEDDQKRLLV TVWNRASQSR QSGLIGCMSF GVKSLLTPDK EISGWYYLLG
160 170 180 190 200
EHLGRTKHLK VARRRLRPLR DPLLRMPGGG DTENGKKLKI TIPRGKDGFG
210 220 230 240 250
FTICCDSPVR VQAVDSGGPA ERAGLQQLDT VLQLNERPVE HWKCVELAHE
260 270 280 290 300
IRSCPSEIIL LVWRMVPQVK PGPDGGVLRR ASCKSTHDLQ SPPNKREKNC
310 320 330 340 350
THGVQARPEQ RHSCHLVCDS SDGLLLGGWE RYTEVAKRGG QHTLPALSRA
360 370 380 390 400
TAPTDPNYII LAPLNPGSQL LRPVYQEYTI PEESGSPSKG KSYTGLGKKS
410 420 430 440 450
RLMKTVQTMK GHGNYQNCPV VRPHATHSSY GTYVTLAPKV LVFPVFVQPL
460 470 480 490 500
DLCNPARTLL LSEGLLLYEG RNKAAEVTLF AYSDLLLFTK EDEPGRCDVL
510 520 530 540 550
RNPLYLQSVK LQEGSSEDLK FCVLYLAEKA ECLFTLEAHS QEQKKRVCWC
560 570 580 590 600
LSENIAKQQQ LAASPPDSKM FETEADEKRE MALEEGKGPG AEDSPPSKEP
610 620 630 640 650
SPGQELPPGQ DLPPNKDSPS GQEPAPSQEP LSSKDSATSE GSPPGPDAPP
660 670 680 690 700
SKDVPPCQEP PPAQDLSPCQ DLPAGQEPLP HQDPLLTKDL PAIQESPTRD
710 720 730 740 750
LPPCQDLPPS QVSLPAKALT EDTMSSGDLL AATGDPPAAP RPAFVIPEVR
760 770 780 790 800
LDSTYSQKAG AEQGCSGDEE DAEEAEEVEE GEEGEEDEDE DTSDDNYGER
810 820 830 840 850
SEAKRSSMIE TGQGAEGGLS LRVQNSLRRR THSEGSLLQE PRGPCFASDT
860 870 880 890 900
TLHCSDGEGA ASTWGMPSPS TLKKELGRNG GSMHHLSLFF TGHRKMSGAD
910 920 930 940 950
TVGDDDEASR KRKSKNLAKD MKNKLGIFRR RNESPGAPPA GKADKMMKSF
960 970 980 990 1000
KPTSEEALKW GESLEKLLVH KYGLAVFQAF LRTEFSEENL EFWLACEDFK
1010 1020 1030 1040 1050
KVKSQSKMAS KAKKIFAEYI AIQACKEVNL DSYTREHTKD NLQSVTRGCF
1060 1070 1080
DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN QKKMSPPL
Length:1,088
Mass (Da):120,200
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0ABAE7F29B9F783C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK125059 mRNA Translation: BAG54130.1

NCBI Reference Sequences

More...
RefSeqi
NP_001269852.1, NM_001282923.1
NP_060260.3, NM_017790.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5998

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125059 mRNA Translation: BAG54130.1
RefSeqiNP_001269852.1, NM_001282923.1
NP_060260.3, NM_017790.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB3KWG8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5998

Genome annotation databases

GeneIDi5998

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5998
PharmGKBiPA34374

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5998, 9 hits in 991 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5998

Gene expression databases

GenevisibleiB3KWG8, HS

Family and domain databases

CDDicd08713, RGS_RGS3, 1 hit
Gene3Di1.10.196.10, 2 hits
2.30.29.30, 1 hit
2.30.42.10, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR016137, RGS
IPR034951, RGS_RGS3
IPR036305, RGS_sf
IPR024066, RGS_subdom1/3
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00595, PDZ, 1 hit
PF00615, RGS, 1 hit
PRINTSiPR01301, RGSPROTEIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00228, PDZ, 1 hit
SM00315, RGS, 1 hit
SUPFAMiSSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50106, PDZ, 1 hit
PS50132, RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KWG8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KWG8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 7, 2021
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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