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Protein
Submitted name:

Histidine--tRNA ligase, cytoplasmic

Gene

HARS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseImported, Ligase

Names & Taxonomyi

Protein namesi
Submitted name:
Histidine--tRNA ligase, cytoplasmicImported
Submitted name:
Histidyl-tRNA synthetase, isoform CRA_aImported
Submitted name:
cDNA FLJ42841 fis, clone BRCOC2003213, highly similar to Histidyl-tRNA synthetase (EC 6.1.1.21)Imported
Gene namesi
Name:HARSImported
ORF Names:hCG_1782886Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170445.12
HGNCiHGNC:4816 HARS

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170445

PTM / Processingi

Proteomic databases

MaxQBiB3KWE1
PRIDEiB3KWE1

Expressioni

Gene expression databases

BgeeiENSG00000170445

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 324AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili321 – 348Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1936 Eukaryota
COG0124 LUCA
GeneTreeiENSGT00390000005922
HOGENOMiHOG000018075
HOVERGENiHBG002731

Family and domain databases

CDDicd00859 HisRS_anticodon, 1 hit
Gene3Di3.40.50.800, 1 hit
InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR015807 His-tRNA-ligase
IPR004516 HisRS/HisZ
IPR033656 HisRS_anticodon
PANTHERiPTHR11476 PTHR11476, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PIRSFiPIRSF001549 His-tRNA_synth, 1 hit
TIGRFAMsiTIGR00442 hisS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

B3KWE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVREKVFDV IIRCFKRHGA EVIDTPVFEL KETLMGKYGE DSKLIYDLKD
60 70 80 90 100
QGGELLSLRY DLTVPFARYL AMNKLTNIKR YHIAKVYRRD NPAMTRGRYR
110 120 130 140 150
EFYQCDFDIA GNFDPMIPDA ECLKIMCEIL SSLQIGDFLV KVNDRRILDG
160 170 180 190 200
MFAICGVSDS KFRTICSSVD KLDKVSWEEV KNEMVGEKGL APEVADRIGD
210 220 230 240 250
YVQQHGGVSL VEQLLQDPKL SQNKQALEGL GDLKLLFEYL TLFGIDDKIS
260 270 280 290 300
FDLSLARGLD YYTGVIYEAV LLQTPAQAGE EPLGVGSVAA GGRYDGLVGM
310 320 330 340 350
FDPKGRKVPC VGLSIGVERI FSIVEQRLEA LEEKIRTTET QVLVASAQKK
360 370 380 390 400
LLEERLKLVS ELWDAGIKAE LLYKKNPKLL NQLQYCEEAG IPLVAIIGEQ
410 420 430 440
ELKDGVIKLR SVTSREEVDV RREDLVEEIK RRTGQPLCIC
Length:440
Mass (Da):49,623
Last modified:September 2, 2008 - v1
Checksum:iB98094B7E3F33779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116353 Genomic DNA No translation available.
AK124831 mRNA Translation: BAG54103.1
CH471062 Genomic DNA Translation: EAW62021.1
UniGeneiHs.528050

Genome annotation databases

EnsembliENST00000504366; ENSP00000430063; ENSG00000170445
UCSCiuc003lgu.5 human

Similar proteinsi

Entry informationi

Entry nameiB3KWE1_HUMAN
AccessioniPrimary (citable) accession number: B3KWE1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 18, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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