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Entry version 55 (02 Jun 2021)
Sequence version 1 (02 Sep 2008)
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Protein
Submitted name:

cDNA FLJ41838 fis, clone NT2RI3001515, highly similar to G-protein coupled receptor-associated sorting protein 2

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ41838 fis, clone NT2RI3001515, highly similar to G-protein coupled receptor-associated sorting protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
B3KW05

PRoteomics IDEntifications database

More...
PRIDEi
B3KW05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B3KW05, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini593 – 836Arm_2InterPro annotationAdd BLAST244

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 122DisorderedSequence analysisAdd BLAST122
Regioni218 – 292DisorderedSequence analysisAdd BLAST75
Regioni349 – 368DisorderedSequence analysisAdd BLAST20
Regioni531 – 552DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 35Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi223 – 242Polar residuesSequence analysisAdd BLAST20
Compositional biasi244 – 258Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi275 – 292Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GPRASP family.ARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

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OMAi
WPREEAN

Database of Orthologous Groups

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OrthoDBi
860703at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006911, ARM-rpt_dom
IPR016024, ARM-type_fold
IPR043374, BHLHb9/GASP-1/GASP-2

The PANTHER Classification System

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PANTHERi
PTHR46414, PTHR46414, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04826, Arm_2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KW05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGAEIEPSA QAKPEKKAGE EVIAGPEREN DVPLVVRPKV RTQATTGARP
60 70 80 90 100
KTETKSVPAA RPKTEAQAMS GARPKTEVQV MGGARPKTEA QRITGARPKT
110 120 130 140 150
DARAVGGARS KTDAKAIPGA RPKDEAQAWA QSEFGTEAVS QAEGVSQTNA
160 170 180 190 200
VAWPLATAES GSVTKSKGLS MDRELVNVDA ETFPGTQGQK GIQPWFGPGE
210 220 230 240 250
ETNMGSWCYS RPRAREEASN ESGFWSADET STASSFWTGE ETSVRSWPRE
260 270 280 290 300
ESNTRSRHRA KHQTNPRSRP RSKQEAYVDS WSGSEDEASN PFSFWVGENT
310 320 330 340 350
NNLFRPRVRE EANIRSKLRT NREDCFESES EDEFYKQSWV LPGEEANSRF
360 370 380 390 400
RHRDKEDPNT ALKLRAQKDV DSDRVKQEPR FEEEVIIGSW FWAEKEASLE
410 420 430 440 450
GGASAICESE PGTEEGAIGG SAYWAEEKSS LGAVAREEAK PESEEEAIFG
460 470 480 490 500
SWFWDRDEAC FDLNPCPVYK VSDRFRDAAE ELNASSRPQT WDEVTVEFKP
510 520 530 540 550
GLFHGVGFRS TSPFGIPEEA SEMLEAKPKN LELSPEGEEQ ESLLQPDQPS
560 570 580 590 600
PEFTFQYDPS YRSVREIREH LRARESAESE SWSCSCIQCE LKIGSEEFEE
610 620 630 640 650
FLLLMDKIRD PFIHEISKIA MGMRSASQFT RDFIRDSGVV SLIGTLLNYP
660 670 680 690 700
SSRVRTSFLE NMIHMAPPYP NLNMIETFIC QVCEETLAHS VDSLEQLTGI
710 720 730 740 750
RMLRHLTMTI DYHTLIANYM SGFLSLLTTA NARTKFHVLK MLLNLSENPA
760 770 780 790 800
VAKKLFSAKA LSIFVGLFNI EETNDNIQIV IKMFQNISNI IKSGKMSLID
810 820 830
DDFSLEPLIS AFREFEELAK QLQAQIDNQN DPEVGQQS
Length:838
Mass (Da):93,800
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6232DB5A39E4D9FC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK123832 mRNA Translation: BAG53967.1

NCBI Reference Sequences

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RefSeqi
NP_001004051.1, NM_001004051.3
NP_001171803.1, NM_001184874.2
NP_001171804.1, NM_001184875.2
NP_001171805.1, NM_001184876.2
NP_612446.1, NM_138437.5

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:114928

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123832 mRNA Translation: BAG53967.1
RefSeqiNP_001004051.1, NM_001004051.3
NP_001171803.1, NM_001184874.2
NP_001171804.1, NM_001184875.2
NP_001171805.1, NM_001184876.2
NP_612446.1, NM_138437.5

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB3KW05
PRIDEiB3KW05

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
114928

Genome annotation databases

GeneIDi114928
KEGGihsa:114928

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114928

Phylogenomic databases

OMAiWPREEAN
OrthoDBi860703at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
114928, 7 hits in 616 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114928

Gene expression databases

GenevisibleiB3KW05, HS

Family and domain databases

InterProiView protein in InterPro
IPR006911, ARM-rpt_dom
IPR016024, ARM-type_fold
IPR043374, BHLHb9/GASP-1/GASP-2
PANTHERiPTHR46414, PTHR46414, 1 hit
PfamiView protein in Pfam
PF04826, Arm_2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KW05_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KW05
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 2, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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