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Entry version 62 (28 Mar 2018)
Sequence version 1 (02 Sep 2008)
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Protein
Submitted name:

cDNA FLJ16538 fis, clone OCBBF2033295, highly similar to Protein neurobeachin

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
B3KVG9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ16538 fis, clone OCBBF2033295, highly similar to Protein neurobeachinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

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PeptideAtlasi
B3KVG9

PRoteomics IDEntifications database

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PRIDEi
B3KVG9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
B3KVG9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini448 – 556BEACH-type PHInterPro annotationAdd BLAST109
Domaini575 – 864BEACHInterPro annotationAdd BLAST290
Domaini1159 – 1242WD_REPEATS_REGIONInterPro annotationAdd BLAST84

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1786 Eukaryota
ENOG410XNQC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007936

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG059380

Family and domain databases

Conserved Domains Database

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CDDi
cd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1540.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR010508 DUF1088
IPR023362 PH-BEACH_dom
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF02138 Beach, 1 hit
PF06469 DUF1088, 1 hit
PF14844 PH_BEACH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KVG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELLSTLSS EVKKSQESLT ENPSETLKPA TSISSISQTK GINVKEILKS
60 70 80 90 100
LVAAPVEIAE CGPEPIPYPD PALKRETQAI LPMQFHSFDR SVVVPVKKPP
110 120 130 140 150
PGSLAVTTVG ATTAGSGLPT GSTSNIFAAT GATPKSMINT TGAVDSGSSS
160 170 180 190 200
SSSSSSFVNG ATSKNLPAVQ TVAPMPEDSA ENMSITAKLE RALEKVAPLL
210 220 230 240 250
REIFVDFAPF LSRTLLGSHG QELLIEGLVC MKSSTSVVEL VMLLCSQEWQ
260 270 280 290 300
NSIQKNAGLA FIELINEGRL LCHAMKDHIV RVANEAEFIL NRQRSEDVHK
310 320 330 340 350
HAEFESQCAQ YAADRREEEK MCDHLISAAK HRDHVTANQL KQKILNILTN
360 370 380 390 400
KHGAWGAVSH SQLHDFWRLD YWEDDLRRRR RFVRNAFGST HAEALLKAAI
410 420 430 440 450
EYGTEEDVVK SKKTFRSQAI VNQNAETELM LEGDDDAVSL LQEKEIDNLA
460 470 480 490 500
GPVVLSTPAQ LIAPVVVAKG TLSITTTEIY FEVDEDDSAF KKIDTKVLAY
510 520 530 540 550
TEGLHGKWMF SEIRAVFSRR YLLQNTALEV FMANRTSVMF NFPDQATVKK
560 570 580 590 600
VVYSLPRVGV GTSYGLPQAR RISLATPRQL YKSSNMTQRW QRREISNFEY
610 620 630 640 650
LMFLNTIAGR TYNDLNQYPV FPWVLTNYES EELDLTLPGN FRDLSKPIGA
660 670 680 690 700
LNPKRAVFYA ERYETWEDDQ SPPYHYNTHY STATSTLSWL VRIEPFTTFF
710 720 730 740 750
LNANDGKFDH PDRTFSSVAR SWRTSQRDTS DVKELIPEFY YLPEMFVNSN
760 770 780 790 800
GYNLGVREDE VVVNDVDLPP WAKKPEDFVR INRMALESEF VSCQLHQWID
810 820 830 840 850
LIFGYKQRGP EAVRALNVFH YLTYEGSVNL DSITDPVLRE AMEAQIQNFG
860 870 880 890 900
QTPSQLLIEP HPPRSSAMHL CFLPQSPLMF KDQMQQDVIM VLKFPSNSPV
910 920 930 940 950
THVAANTLPH LTIPAVVTVT CSRLFAVNRW HNTVGLRGAP GYSLDQAHHL
960 970 980 990 1000
PIEMDPLIAN NSGVNKRQIT DLVDQSIQIN AHCFVVTADN RYILICGFWD
1010 1020 1030 1040 1050
KSFRVYSTET GKLTQIVFGH WDVVTCLARS ESYIGGDCYI VSGSRDATLL
1060 1070 1080 1090 1100
LWYWSGRHHI IGDNPNSSDY PAPRAVLTGH DHEVVCVSVC AELGLVISGA
1110 1120 1130 1140 1150
KEGPCLVHTI TGDLLRALEG PENCLFPRLI SVSSEGHCII YYERGRFSNF
1160 1170 1180 1190 1200
SINGKLLAQM EINDSTRAIL LSSDGQNLVT GGDNGVVEVW QACDFKQLYI
1210 1220 1230 1240
YPGCDAGIRA MDLSHDQRTL ITGMASGSIV AFNIDFNRWH YEHQNRY
Length:1,247
Mass (Da):139,433
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61DF601B10870E11
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK122888 mRNA Translation: BAG53781.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.491172

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122888 mRNA Translation: BAG53781.1
UniGeneiHs.491172

3D structure databases

ProteinModelPortaliB3KVG9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB3KVG9
PRIDEiB3KVG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1786 Eukaryota
ENOG410XNQC LUCA
HOGENOMiHOG000007936
HOVERGENiHBG059380

Enzyme and pathway databases

SignaLinkiB3KVG9

Family and domain databases

CDDicd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
InterProiView protein in InterPro
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR010508 DUF1088
IPR023362 PH-BEACH_dom
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF06469 DUF1088, 1 hit
PF14844 PH_BEACH, 1 hit
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KVG9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KVG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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