UniProtKB - B3KUJ9 (B3KUJ9_HUMAN)
Mediator of RNA polymerase II transcription subunit 20
TRFP
Functioni
GO - Molecular functioni
- transcription coregulator activity Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | ActivatorUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 20UniRule annotationAlternative name(s): Mediator complex subunit 20UniRule annotation |
Gene namesi | Name:TRFPImported Synonyms:MED20UniRule annotation ORF Names:hCG_2000813Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- mediator complex Source: InterPro
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationInteractioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR013921, Mediator_Med20 |
PANTHERi | PTHR12465, PTHR12465, 1 hit |
Pfami | View protein in Pfam PF08612, Med20, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MYVMHNSEYP LSCFALFENG PCLIADTNFD VLMVKLKGFF QSAKASKIET
60 70 80 90 100
RGTRYQYCDF LVKVGTVTMG PSARGISVEV EYGPCVVASD CWSLLLEFLQ
110 120 130 140 150
SFLGSHTPGA PAVFGNRHDA VYGPADTMVQ YMELFNKIRK QQQVPVAGIR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097385 mRNA Translation: BAG53461.1 AK300573 mRNA Translation: BAG62275.1 CH471081 Genomic DNA Translation: EAX04068.1 |
RefSeqi | NP_001292384.1, NM_001305455.1 NP_001292385.1, NM_001305456.1 |
Genome annotation databases
GeneIDi | 9477 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097385 mRNA Translation: BAG53461.1 AK300573 mRNA Translation: BAG62275.1 CH471081 Genomic DNA Translation: EAX04068.1 |
RefSeqi | NP_001292384.1, NM_001305455.1 NP_001292385.1, NM_001305456.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B3KUJ9 |
Genome annotation databases
GeneIDi | 9477 |
Organism-specific databases
CTDi | 9477 |
Miscellaneous databases
BioGRID-ORCSi | 9477, 621 hits in 844 CRISPR screens |
ChiTaRSi | MED20, human |
GenomeRNAii | 9477 |
Family and domain databases
InterProi | View protein in InterPro IPR013921, Mediator_Med20 |
PANTHERi | PTHR12465, PTHR12465, 1 hit |
Pfami | View protein in Pfam PF08612, Med20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B3KUJ9_HUMAN | |
Accessioni | B3KUJ9Primary (citable) accession number: B3KUJ9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |