Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 78 (12 Aug 2020)
Sequence version 1 (02 Sep 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

cDNA FLJ39327 fis, clone OCBBF2015506, highly similar to Mus musculus FAT tumor suppressor homolog 4 (Drosophila) (Fat4), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ39327 fis, clone OCBBF2015506, highly similar to Mus musculus FAT tumor suppressor homolog 4 (Drosophila) (Fat4), mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei568 – 592HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134954366

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 40PROSITE-ProRule annotation
Disulfide bondi255 ↔ 264PROSITE-ProRule annotation
Disulfide bondi519 ↔ 528PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B3KU84

PRoteomics IDEntifications database

More...
PRIDEi
B3KU84

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B3KU84, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 41EGF-likeInterPro annotationAdd BLAST37
Domaini42 – 226LAM_G_DOMAINInterPro annotationAdd BLAST185
Domaini229 – 265EGF-likeInterPro annotationAdd BLAST37
Domaini284 – 464LAM_G_DOMAINInterPro annotationAdd BLAST181
Domaini492 – 529EGF-likeInterPro annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni600 – 650DisorderedSequence analysisAdd BLAST51
Regioni746 – 779DisorderedSequence analysisAdd BLAST34
Regioni818 – 922DisorderedSequence analysisAdd BLAST105
Regioni935 – 977DisorderedSequence analysisAdd BLAST43
Regioni1023 – 1047DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi600 – 621PolyampholyteSequence analysisAdd BLAST22
Compositional biasi877 – 891PolyampholyteSequence analysisAdd BLAST15
Compositional biasi939 – 955PolyampholyteSequence analysisAdd BLAST17

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16669

Database of Orthologous Groups

More...
OrthoDBi
34489at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 3 hits
SM00179, EGF_CA, 3 hits
SM00282, LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 4 hits
PS50026, EGF_3, 3 hits
PS50025, LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KU84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCESSVNYCE CNPCFNGGSC QSGVDSYYCH CPFGVFGKHC ELNSYGFEEL
60 70 80 90 100
SYMEFPSLDP NNNYIYVKFA TIKSHALLLY NYDNQTGDRA EFLALEIAEE
110 120 130 140 150
RLRFSYNLGS GTYKLTTMKK VSDGHFHTVI ARRAGMAASL TVDSCSENQE
160 170 180 190 200
PGYCTVSNVA VSDDWTLDVQ PNRVTVGGIR SLEPILQRRG HVESHDFVGC
210 220 230 240 250
IMEFAVNGRP LEPSQALAAQ GILDQCPRLE GACTRSPCQH GGTCMDYWSW
260 270 280 290 300
QQCHCKEGLT GKYCEKSVTP DTALSLEGKG RLDYHMSQNE KREYLLRQSL
310 320 330 340 350
RGAMLEPFGV NSLEVKFRTR SENGVLIHIQ ESSNYTTVKI KNGKVYFTSD
360 370 380 390 400
AGIAGKVERN IPEVYVADGH WHTFLIGKNG TATVLSVDRI YNRDIIHPTQ
410 420 430 440 450
DFGGLDVLTI SLGGIPPNQA HRDAQTGFDG CIASMWYGGE SLPFSGKHSL
460 470 480 490 500
ASISKTDPSV KIGCRGPNIC ASNPCWGGLL CINQWYAYRC VPPGDCASHP
510 520 530 540 550
CQNGGSCEPG LHSGFTCSCP DSHTGRTCEM VVACLGVLCP QGKVCKAGSP
560 570 580 590 600
AGHVCVLSQG PEEISLPLWA VPAIVGSCAT VLALLVLSLI LCNQCRGKKA
610 620 630 640 650
KNPKEEKKPK EKKKKGSENV AFDDPDNIPP YGDDMTVRKQ PEGNPKPDII
660 670 680 690 700
ERENPYLIYD ETDIPHNSET IPSAPLASPE QEIEHYDIDN ASSIAPSDAD
710 720 730 740 750
IIQHYKQFRS HTPKFSIQRH SPLGFARQSP MPLGASSLTY QPSYGQGLRT
760 770 780 790 800
SSLSHSACPT PNPLSRHSPA PFSKSSTFYR NSPARELHLP IRDGNTLEMH
810 820 830 840 850
GDTCQPGIFN YATRLGRRSK SPQAMASHGS RPGSRLKQPI GQIPLESSPP
860 870 880 890 900
VGLSIEEVER LNTPRPRNPS ICSADHGRSS SEEDCRRPLS RTRNPADGIP
910 920 930 940 950
APESSSDSDS HESFTCSEME YDREKPMVYT SRMPKLSQVN ESDADDEDNY
960 970 980 990 1000
GARLKPRRYH GRRAEGGPVG TQAAAPGTAD NTLPMKLGQQ AGTFNWDNLL
1010 1020 1030 1040
NWGPGFGHYV DVFKDLASLP EKAAANEEGK AGTTKPVPKD GEAEQYV
Length:1,047
Mass (Da):114,637
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4EAD06318FF2E5F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK096646 mRNA Translation: BAG53346.1

NCBI Reference Sequences

More...
RefSeqi
NP_001278214.1, NM_001291285.1
NP_001278232.1, NM_001291303.1
NP_078858.4, NM_024582.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79633

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79633

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096646 mRNA Translation: BAG53346.1
RefSeqiNP_001278214.1, NM_001291285.1
NP_001278232.1, NM_001291303.1
NP_078858.4, NM_024582.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB3KU84
PRIDEiB3KU84

Genome annotation databases

GeneIDi79633
KEGGihsa:79633

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79633
PharmGKBiPA134954366

Phylogenomic databases

KOiK16669
OrthoDBi34489at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79633, 4 hits in 868 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79633

Gene expression databases

GenevisibleiB3KU84, HS

Family and domain databases

InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 2 hits
SMARTiView protein in SMART
SM00181, EGF, 3 hits
SM00179, EGF_CA, 3 hits
SM00282, LamG, 2 hits
SUPFAMiSSF49899, SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 4 hits
PS50026, EGF_3, 3 hits
PS50025, LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KU84_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KU84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: August 12, 2020
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again