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Entry version 66 (26 Feb 2020)
Sequence version 2 (22 Nov 2017)
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Protein

IQCJ-SCHIP1 readthrough transcript protein

Gene

IQCJ-SCHIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IQCJ-SCHIP1 readthrough transcript proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQCJ-SCHIP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:38842 IQCJ-SCHIP1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_B3KU38

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100505385

Open Targets

More...
OpenTargetsi
ENSG00000283154

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
B3KU38 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IQCJ-SCHIP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004423341 – 563IQCJ-SCHIP1 readthrough transcript proteinAdd BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei193PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
B3KU38

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
B3KU38

PRoteomics IDEntifications database

More...
PRIDEi
B3KU38

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B3KU38

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain and to a lower extent in heart and kidney.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform IQCJ-SCHIP1-1 and isoform IQCJ-SCHIP1-2 are expressed in fetal brain, kidney, spleen and skeletal muscle. Isoform IQCJ-SCHIP1-2 is also detected in fetal heart and lung.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B3KU38 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B3KU38 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003243
HPA003445

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (via coiled coil domain).

Interacts (via IQ domain) with calmodulin; the interaction is direct and lost in presence of calcium (By similarity).

Interacts with ANK3 (via ANK repeats); required for localization at axon initial segments (AIS) and nodes of Ranvier (PubMed:25950943).

Interacts with SPTBN4.

Interacts with KCNQ2 and KCNQ3 (By similarity).

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000420182

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3KU38

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 67IQAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni419 – 563Required for interaction with ankyrinsBy similarityAdd BLAST145

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili500 – 534Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 143Ser-richPROSITE-ProRule annotationAdd BLAST73
Compositional biasi151 – 182Glu-richPROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4847 Eukaryota
ENOG4111HYM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011127

Identification of Orthologs from Complete Genome Data

More...
OMAi
XLQSGMN

Database of Orthologous Groups

More...
OrthoDBi
1290403at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029362 IQCJ-SCHIP1_N
IPR039045 SCHIP_1
IPR015649 SCHIP_1_C

The PANTHER Classification System

More...
PANTHERi
PTHR13103 PTHR13103, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15157 IQCJ-SCHIP1, 1 hit
PF10148 SCHIP-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform IQCJ-SCHIP1-1 (identifier: B3KU38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLEELKRLQ NPLEQVNDGK YSFENHQLAM DAENNIEKYP LNLQPLESKV
60 70 80 90 100
KIIQRAWREY LQRQEPLGKR SPSPPSVSSE KLSSSVSMNT FSDSSTPDYR
110 120 130 140 150
EDGMDLGSDA GSSSSSSRAS SQSNSTKVTP CSECKSSSSP GGSLDLVSAL
160 170 180 190 200
EDYEEPFPVY QKKVIDEWAP EEDGEEEEEE DERDQRGYRD DRSPAREPGD
210 220 230 240 250
VSARTRSGGG GGRSATTAMP PPVPNGNLHQ HDPQDLRHNG NVVVAGRPSC
260 270 280 290 300
SRGPRRAIQK PQPAGGRRSG RGPAAGGLCL QPPDGGTCVP EEPPVPPMDW
310 320 330 340 350
EALEKHLAGL QFREQEVRNQ GQARTNSTSA QKNERESIRQ KLALGSFFDD
360 370 380 390 400
GPGIYTSCSK SGKPSLSSRL QSGMNLQICF VNDSGSDKDS DADDSKTETS
410 420 430 440 450
LDTPLSPMSK QSSSYSDRDT TEEESESLDD MDFLTRQKKL QAEAKMALAM
460 470 480 490 500
AKPMAKMQVE VEKQNRKKSP VADLLPHMPH ISECLMKRSL KPTDLRDMTI
510 520 530 540 550
GQLQVIVNDL HSQIESLNEE LVQLLLIRDE LHTEQDAMLV DIEDLTRHAE
560
SQQKHMAEKM PAK
Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.1 Publication
Length:563
Mass (Da):62,248
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54C0F2D21E4B2739
GO
Isoform IQCJ-SCHIP1-2 (identifier: B3KU38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-52: Missing.

Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.1 Publication
Show »
Length:536
Mass (Da):59,129
Checksum:i6FB3CEF2E518FD02
GO
Isoform SCHIP1-1 (identifier: P0DPB3-1) [UniParc] [UniParc]FASTAAdd to basket
Also known as: SCHIP-1, SCHIP-1a
The sequence of this isoform can be found in the external entry P0DPB3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:487
Mass (Da):53,480
GO
Isoform SCHIP1-2 (identifier: P0DPB3-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: SCHIP-1-D241/253
The sequence of this isoform can be found in the external entry P0DPB3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:474
Mass (Da):52,079
GO
Isoform SCHIP1-3 (identifier: P0DPB3-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: SCHIP-1-D22/253
The sequence of this isoform can be found in the external entry P0DPB3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:255
Mass (Da):28,691
GO
Isoform SCHIP1-4 (identifier: P0DPB3-4) [UniParc] [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DPB3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:244
Mass (Da):27,492
GO
Isoform IQCJ-1 (identifier: Q1A5X6-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q1A5X6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:159
Mass (Da):18,226
GO
Isoform IQCJ-2 (identifier: Q1A5X6-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q1A5X6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:112
Mass (Da):12,920
GO
Isoform IQCJ-3 (identifier: Q1A5X6-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q1A5X6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:132
Mass (Da):15,107
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J366C9J366_HUMAN
IQCJ-SCHIP1 readthrough transcript ...
IQCJ-SCHIP1
451Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQT1A0A1W2PQT1_HUMAN
IQCJ-SCHIP1 readthrough transcript ...
IQCJ-SCHIP1
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PR91A0A1W2PR91_HUMAN
IQCJ-SCHIP1 readthrough transcript ...
IQCJ-SCHIP1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PP08A0A1W2PP08_HUMAN
IQCJ-SCHIP1 readthrough transcript ...
IQCJ-SCHIP1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPY3A0A1W2PPY3_HUMAN
IQCJ-SCHIP1 readthrough transcript ...
IQCJ-SCHIP1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRV6A0A1W2PRV6_HUMAN
IQCJ-SCHIP1 readthrough transcript ...
IQCJ-SCHIP1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PR78A0A1W2PR78_HUMAN
IQCJ-SCHIP1 readthrough transcript ...
IQCJ-SCHIP1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRY4A0A1W2PRY4_HUMAN
IQCJ-SCHIP1 readthrough transcript ...
IQCJ-SCHIP1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230Q → R in BAG53300 (PubMed:14702039).Curated1
Sequence conflicti230Q → R in ABA42890 (PubMed:17045569).Curated1
Sequence conflicti230Q → R in ABA42889 (PubMed:17045569).Curated1
Sequence conflicti536D → A in BAG53300 (PubMed:14702039).Curated1
Sequence conflicti536D → A in ABA42890 (PubMed:17045569).Curated1
Sequence conflicti536D → A in ABA42889 (PubMed:17045569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05922726 – 52Missing in isoform IQCJ-SCHIP1-2. Add BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ157847 mRNA Translation: ABA42889.1
DQ157848 mRNA Translation: ABA42890.1
AK096479 mRNA Translation: BAG53300.1
AC021654 Genomic DNA No translation available.
AC063955 Genomic DNA No translation available.
AC068770 Genomic DNA No translation available.
AC092861 Genomic DNA No translation available.
AC092943 Genomic DNA No translation available.
AC092997 Genomic DNA No translation available.
AC107312 Genomic DNA No translation available.
AC131150 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56289.1 [B3KU38-1]
CCDS56291.1 [B3KU38-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001184042.1, NM_001197113.1 [B3KU38-1]
NP_001184043.1, NM_001197114.1 [B3KU38-2]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
100505385

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100505385

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ157847 mRNA Translation: ABA42889.1
DQ157848 mRNA Translation: ABA42890.1
AK096479 mRNA Translation: BAG53300.1
AC021654 Genomic DNA No translation available.
AC063955 Genomic DNA No translation available.
AC068770 Genomic DNA No translation available.
AC092861 Genomic DNA No translation available.
AC092943 Genomic DNA No translation available.
AC092997 Genomic DNA No translation available.
AC107312 Genomic DNA No translation available.
AC131150 Genomic DNA No translation available.
CCDSiCCDS56289.1 [B3KU38-1]
CCDS56291.1 [B3KU38-2]
RefSeqiNP_001184042.1, NM_001197113.1 [B3KU38-1]
NP_001184043.1, NM_001197114.1 [B3KU38-2]

3D structure databases

SMRiB3KU38
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000420182

PTM databases

iPTMnetiB3KU38

Polymorphism and mutation databases

BioMutaiIQCJ-SCHIP1

Proteomic databases

jPOSTiB3KU38
MassIVEiB3KU38
PRIDEiB3KU38

Genome annotation databases

GeneIDi100505385
KEGGihsa:100505385

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
100505385
DisGeNETi100505385

GeneCards: human genes, protein and diseases

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GeneCardsi
IQCJ-SCHIP1
HGNCiHGNC:38842 IQCJ-SCHIP1
HPAiHPA003243
HPA003445
neXtProtiNX_B3KU38
OpenTargetsiENSG00000283154

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4847 Eukaryota
ENOG4111HYM LUCA
GeneTreeiENSGT00390000011127
OMAiXLQSGMN
OrthoDBi1290403at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IQCJ-SCHIP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
100505385
PharosiB3KU38 Tdark

Protein Ontology

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PROi
PR:B3KU38

Gene expression databases

ExpressionAtlasiB3KU38 baseline and differential
GenevisibleiB3KU38 HS

Family and domain databases

InterProiView protein in InterPro
IPR029362 IQCJ-SCHIP1_N
IPR039045 SCHIP_1
IPR015649 SCHIP_1_C
PANTHERiPTHR13103 PTHR13103, 1 hit
PfamiView protein in Pfam
PF15157 IQCJ-SCHIP1, 1 hit
PF10148 SCHIP-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQIP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KU38
Secondary accession number(s): B3KRM0
, O75543, Q00P30, Q00P31, Q7Z3Y3, Q8IY83, Q9P0W3, Q9P0W4, Q9P0W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: November 22, 2017
Last modified: February 26, 2020
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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