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UniProtKB - B3KTP4 (B3KTP4_HUMAN)
Protein
Submitted name:
Apolipoprotein L, 6
Gene
APOL6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- lipid binding Source: InterPro
GO - Biological processi
- lipid transport Source: InterPro
- lipoprotein metabolic process Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Apolipoprotein L, 6ImportedSubmitted name: Apolipoprotein L6ImportedSubmitted name: cDNA FLJ38562 fis, clone HCHON2004002, highly similar to Apolipoprotein-L6Imported |
Gene namesi | Name:APOL6Imported Synonyms:ApoL6Imported ORF Names:hCG_1648009Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000221963 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 79 – 101 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 107 – 126 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 324 – 342 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000221963, Expressed in pericardium and 216 other tissues |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 50 – 70 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 268 – 295 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the apolipoprotein L family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_046288_0_1_1 |
OMAi | CETEAYW |
OrthoDBi | 1363478at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR008405, ApoL |
PANTHERi | PTHR14096, PTHR14096, 1 hit |
Pfami | View protein in Pfam PF05461, ApoL, 1 hit |
i Sequence
Sequence statusi: Complete.
B3KTP4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK
60 70 80 90 100
EDLKGNIDKL RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP
110 120 130 140 150
ATGGGSLLLS TAGQGLATAA GVTSIVSGTL ERSKNKEAQA RAEDILPTYD
160 170 180 190 200
QEDREDEEEK ADYVTAAGKI IYNLRNTLKY AKKNVRAFWK LRANPRLANA
210 220 230 240 250
TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM SAFSLGYDLA
260 270 280 290 300
TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA
310 320 330 340
RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ177991 Genomic DNA Translation: ACN51253.1 AK095881 mRNA Translation: BAG53156.1 LC420316 mRNA Translation: BBG06133.1 CH471095 Genomic DNA Translation: EAW60069.1 |
RefSeqi | NP_085144.1, NM_030641.3 XP_011528694.1, XM_011530392.2 |
Genome annotation databases
GeneIDi | 80830 |
KEGGi | hsa:80830 |
MANE-Selecti | ENST00000409652.5; ENSP00000386280.3; NM_030641.4; NP_085144.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ177991 Genomic DNA Translation: ACN51253.1 AK095881 mRNA Translation: BAG53156.1 LC420316 mRNA Translation: BBG06133.1 CH471095 Genomic DNA Translation: EAW60069.1 |
RefSeqi | NP_085144.1, NM_030641.3 XP_011528694.1, XM_011530392.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B3KTP4, 4 interactors |
Protocols and materials databases
Antibodypediai | 25455, 263 antibodies from 30 providers |
DNASUi | 80830 |
Genome annotation databases
GeneIDi | 80830 |
KEGGi | hsa:80830 |
MANE-Selecti | ENST00000409652.5; ENSP00000386280.3; NM_030641.4; NP_085144.1 |
Organism-specific databases
CTDi | 80830 |
PharmGKBi | PA24909 |
VEuPathDBi | HostDB:ENSG00000221963 |
Phylogenomic databases
HOGENOMi | CLU_046288_0_1_1 |
OMAi | CETEAYW |
OrthoDBi | 1363478at2759 |
Miscellaneous databases
BioGRID-ORCSi | 80830, 14 hits in 1079 CRISPR screens |
ChiTaRSi | APOL6, human |
GenomeRNAii | 80830 |
Gene expression databases
Bgeei | ENSG00000221963, Expressed in pericardium and 216 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR008405, ApoL |
PANTHERi | PTHR14096, PTHR14096, 1 hit |
Pfami | View protein in Pfam PF05461, ApoL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B3KTP4_HUMAN | |
Accessioni | B3KTP4Primary (citable) accession number: B3KTP4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | May 25, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |