UniProtKB - B3KT21 (B3KT21_HUMAN)
Protein
BH3-interacting domain death agonist
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Counters the protective effect of Bcl-2.UniRule annotation
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB-UniRule
- apoptotic process Source: UniProtKB-KW
- positive regulation of apoptotic process Source: InterPro
Keywordsi
Biological process | ApoptosisUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: BH3-interacting domain death agonistUniRule annotationARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Mitochondrion
- Mitochondrion outer membrane UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation
Cytosol
- cytosol Source: UniProtKB-UniRule
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, Membrane, Mitochondrion, Mitochondrion outer membraneUniRule annotationInteractioni
Subunit structurei
Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.
UniRule annotationFamily & Domainsi
Domaini
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.UniRule annotation
Phylogenomic databases
OMAi | MTMLLAK |
OrthoDBi | 1218538at2759 |
Family and domain databases
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR020728, Bcl2_BH3_motif_CS IPR010479, BID IPR036834, Blc2-like_sf |
PANTHERi | PTHR35447, PTHR35447, 1 hit |
Pfami | View protein in Pfam PF06393, BID, 1 hit |
PIRSFi | PIRSF038018, BID, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS01259, BH3, 1 hit |
i Sequence
Sequence statusi: Complete.
B3KT21-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCSGAGVMMA RWAARGRAGW RSTVRILSPL GHCEPGVSRS CRAAQAMDCE
60 70 80 90 100
VNNGSSLRDE CITNLLVFGF LQSCSDSSFR RELDALGHEL PVLAPQWEGY
110 120 130 140 150
DELQTDGNRS SHSRLGRIEA DSESQEDIIR NIARHLAQVG DSMDRSIPPG
160 170 180 190 200
LVNGLALQLR NTSRSEEDRN RDLATALEQL LQAYPRDMEK EKTMLVLALL
210 220 230 240
LAKKVASHTP SLLRDVFHTT VNFINQNLRT YVRSLARNGM D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094795 mRNA Translation: BAG52933.1 |
RefSeqi | NP_001187.1, NM_001196.3 NP_001231496.1, NM_001244567.1 NP_001231498.1, NM_001244569.1 NP_001231499.1, NM_001244570.1 NP_001231501.1, NM_001244572.1 NP_932070.1, NM_197966.2 NP_932071.1, NM_197967.2 |
Genome annotation databases
GeneIDi | 637 |
KEGGi | hsa:637 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094795 mRNA Translation: BAG52933.1 |
RefSeqi | NP_001187.1, NM_001196.3 NP_001231496.1, NM_001244567.1 NP_001231498.1, NM_001244569.1 NP_001231499.1, NM_001244570.1 NP_001231501.1, NM_001244572.1 NP_932070.1, NM_197966.2 NP_932071.1, NM_197967.2 |
3D structure databases
SMRi | B3KT21 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | B3KT21 |
Protocols and materials databases
DNASUi | 637 |
Genome annotation databases
GeneIDi | 637 |
KEGGi | hsa:637 |
Organism-specific databases
CTDi | 637 |
PharmGKBi | PA25353 |
Phylogenomic databases
OMAi | MTMLLAK |
OrthoDBi | 1218538at2759 |
Miscellaneous databases
BioGRID-ORCSi | 637, 21 hits in 999 CRISPR screens |
GenomeRNAii | 637 |
Gene expression databases
Genevisiblei | B3KT21, HS |
Family and domain databases
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR020728, Bcl2_BH3_motif_CS IPR010479, BID IPR036834, Blc2-like_sf |
PANTHERi | PTHR35447, PTHR35447, 1 hit |
Pfami | View protein in Pfam PF06393, BID, 1 hit |
PIRSFi | PIRSF038018, BID, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS01259, BH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B3KT21_HUMAN | |
Accessioni | B3KT21Primary (citable) accession number: B3KT21 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | April 7, 2021 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |