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Entry version 58 (13 Feb 2019)
Sequence version 3 (05 Oct 2010)
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Protein

Serine/arginine repetitive matrix protein 5

Gene

SRRM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Overlaps in opposite strand with ZNF428.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/arginine repetitive matrix protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRRM5
Synonyms:ZNF576
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000226763.4

Human Gene Nomenclature Database

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HGNCi
HGNC:37248 SRRM5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_B3KS81

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000226763

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRRM5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003953061 – 715Serine/arginine repetitive matrix protein 5Add BLAST715

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
B3KS81

PRoteomics IDEntifications database

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PRIDEi
B3KS81

ProteomicsDB human proteome resource

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ProteomicsDBi
3626

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B3KS81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
B3KS81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000226763 Expressed in 80 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
B3KS81 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA047399

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
B3KS81, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B3KS81

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 711Ser-richAdd BLAST710

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J72A Eukaryota
ENOG410YU2B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111657

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG087335

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B3KS81

Identification of Orthologs from Complete Genome Data

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OMAi
RQRGRML

Database of Orthologous Groups

More...
OrthoDBi
710781at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B3KS81

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038787 SRRM5

The PANTHER Classification System

More...
PANTHERi
PTHR39414 PTHR39414, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KS81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSPKRSSKP SMSLAPSGSS MPTADPKPPA SLKSTKSATP NRSLVPTKPA
60 70 80 90 100
TSRNSVMSPS SSKSTKSTST KRAPSNRPSS RSRVRSKART PSRVSTDTRT
110 120 130 140 150
SKASKASDVR CHQRRGTHSR GRTPGRRGSR SSKRSPSRAS TPGRIRTHGA
160 170 180 190 200
RPGMASRVRT PTSQQKGSRG KSYGRPRTSN RERSDSQPRN LSKKSYRPPG
210 220 230 240 250
GSGIGRSSEL AVTPSTAKCQ TPTGIPSKEK SDNPSPSSSR KVKSYGQMII
260 270 280 290 300
PSREKSYSPT EMSSRVKSYN QASTRSRPQS HSQSRSPRRS RSGSQKRTHS
310 320 330 340 350
RVRSHSWKRN HSRARSRTRK GILSQMGRHS QSRSHSKGKS QNQSRTPRRG
360 370 380 390 400
RSHNWSRNPS KERSHSHSRS SSKERDHRGS SSPRKESGRS QSGSPNKQRD
410 420 430 440 450
HSRSRSPNKA RDRSRSRSPY KARDRSRSRS PNKARDCSRS RSPYKARDRS
460 470 480 490 500
RSRSPNKARD HSRSRSPNKA RDRSRSRSPS KERDHSQLGS PSKERDHRRS
510 520 530 540 550
RSPSKERQCR QSRSSSKERD HRRSRSPSKE RQRRQSRSPN KERDRSQSRS
560 570 580 590 600
PSEEREHRQS RSPSKERDRR RWRSPSKERE RRQSRSSSEE RDHSRSRSPN
610 620 630 640 650
KQSGYSRPRA SSKEKAHSRS RTPSKEGNHS QSRTSSKESD PSQSTVPRSP
660 670 680 690 700
DWKRSPTRTS SLSQNRTPSK TSSHSPSTFP SGGQTLSQDD SQADATTSKA
710
TLPGERSSSS SSKLA
Length:715
Mass (Da):80,355
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AF0665D74CAAF26
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG60212 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti375R → G in BAG60212 (PubMed:14702039).Curated1
Sequence conflicti437C → R in BAG60212 (PubMed:14702039).Curated1
Sequence conflicti639S → R in BAG60212 (PubMed:14702039).Curated1
Sequence conflicti694D → N in BAG60212 (PubMed:14702039).Curated1
Sequence conflicti712S → P in BAG52643 (PubMed:14702039).Curated1
Sequence conflicti712S → P in AX747890 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK297891 mRNA Translation: BAG60212.1 Different initiation.
AK093056 mRNA Translation: BAG52643.1
AX747890 mRNA No translation available.
AC006276 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46095.1

NCBI Reference Sequences

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RefSeqi
NP_001139113.1, NM_001145641.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.722032

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000417606; ENSP00000414512; ENSG00000226763
ENST00000607544; ENSP00000476253; ENSG00000226763

Database of genes from NCBI RefSeq genomes

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GeneIDi
100170229

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100170229

UCSC genome browser

More...
UCSCi
uc002oxb.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297891 mRNA Translation: BAG60212.1 Different initiation.
AK093056 mRNA Translation: BAG52643.1
AX747890 mRNA No translation available.
AC006276 Genomic DNA No translation available.
CCDSiCCDS46095.1
RefSeqiNP_001139113.1, NM_001145641.1
UniGeneiHs.722032

3D structure databases

ProteinModelPortaliB3KS81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB3KS81, 1 interactor

PTM databases

iPTMnetiB3KS81
PhosphoSitePlusiB3KS81

Polymorphism and mutation databases

BioMutaiSRRM5

Proteomic databases

PaxDbiB3KS81
PRIDEiB3KS81
ProteomicsDBi3626

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000417606; ENSP00000414512; ENSG00000226763
ENST00000607544; ENSP00000476253; ENSG00000226763
GeneIDi100170229
KEGGihsa:100170229
UCSCiuc002oxb.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100170229
EuPathDBiHostDB:ENSG00000226763.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SRRM5
HGNCiHGNC:37248 SRRM5
HPAiHPA047399
neXtProtiNX_B3KS81
OpenTargetsiENSG00000226763

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J72A Eukaryota
ENOG410YU2B LUCA
GeneTreeiENSGT00730000111657
HOVERGENiHBG087335
InParanoidiB3KS81
OMAiRQRGRML
OrthoDBi710781at2759
PhylomeDBiB3KS81

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100170229

Protein Ontology

More...
PROi
PR:B3KS81

Gene expression databases

BgeeiENSG00000226763 Expressed in 80 organ(s), highest expression level in right testis
GenevisibleiB3KS81 HS

Family and domain databases

InterProiView protein in InterPro
IPR038787 SRRM5
PANTHERiPTHR39414 PTHR39414, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRRM5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KS81
Secondary accession number(s): B4DNF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 5, 2010
Last modified: February 13, 2019
This is version 58 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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