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Protein
Submitted name:

cDNA FLJ34857 fis, clone NT2NE2012533, highly similar to Cadherin-12

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionUniRule annotationSAAS annotation
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ34857 fis, clone NT2NE2012533, highly similar to Cadherin-12Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei216 – 247HelicalSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiB3KRT0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 97CAInterPro annotationAdd BLAST82
Domaini120 – 207CAInterPro annotationAdd BLAST88

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000231252
HOVERGENiHBG005217

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 2 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 2 hits
SUPFAMiSSF49313 SSF49313, 2 hits

Sequencei

Sequence statusi: Complete.

B3KRT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVYEDTPVG TIIGAVTAQD LDVGSSAVRY FIDWKSDGDS YFTIDGNEGT
60 70 80 90 100
IATNELLDRE STAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS
110 120 130 140 150
VPYETAVCEN AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV
160 170 180 190 200
RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC
210 220 230 240 250
RCDSDGTILS CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ
260 270 280 290 300
KKKDTLMTSK EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR
310 320 330 340 350
RDIKPDSLCL PRQRPPMEDN TDIRDFIHQR LQENDVDPTA PPYDSLATYA
360 370 380 390 400
YEGSGSVAES LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD MFGEEESYNP

DKVT
Length:404
Mass (Da):44,962
Last modified:September 2, 2008 - v1
Checksum:i3C25E255F47FC3D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092176 mRNA Translation: BAG52492.1
UniGeneiHs.113684

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092176 mRNA Translation: BAG52492.1
UniGeneiHs.113684

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB3KRT0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000231252
HOVERGENiHBG005217

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 2 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 2 hits
SUPFAMiSSF49313 SSF49313, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiB3KRT0_HUMAN
AccessioniPrimary (citable) accession number: B3KRT0
Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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