UniProtKB - B3KNW7 (B3KNW7_HUMAN)
Protein
Submitted name:
cDNA FLJ30606 fis, clone CTONG2000330, highly similar to Probable global transcription activator SNF2L4
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- histone binding Source: InterPro
- nucleosome-dependent ATPase activity Source: InterPro
GO - Biological processi
- ATP-dependent chromatin remodeling Source: InterPro
Keywordsi
Molecular function | HydrolaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: cDNA FLJ30606 fis, clone CTONG2000330, highly similar to Probable global transcription activator SNF2L4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 54 | Helicase ATP-bindingInterPro annotationAdd BLAST | 54 | |
Domaini | 207 – 369 | Helicase C-terminalInterPro annotationAdd BLAST | 163 | |
Domaini | 567 – 637 | BromoInterPro annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 487 – 550 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 654 – 737 | DisorderedSequence analysisAdd BLAST | 84 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 487 – 509 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 518 – 538 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 659 – 676 | AcidicSequence analysisAdd BLAST | 18 | |
Compositional biasi | 677 – 703 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 719 – 737 | AcidicSequence analysisAdd BLAST | 19 |
Keywords - Domaini
BromodomainPROSITE-ProRule annotationARBA annotationFamily and domain databases
Gene3Di | 1.20.920.10, 1 hit 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR030100, BRG1 IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR029295, SnAC IPR038718, SNF2-like_sf IPR000330, SNF2_dom |
PANTHERi | PTHR10799:SF76, PTHR10799:SF76, 1 hit |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF00271, Helicase_C, 1 hit PF14619, SnAC, 1 hit PF00176, SNF2_N, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00297, BROMO, 1 hit SM00490, HELICc, 1 hit SM01314, SnAC, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 1 hit PS50014, BROMODOMAIN_2, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
i Sequence
Sequence statusi: Complete.
B3KNW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIVDEGHRMK NHHCKLTQVL NTHYVAPRRL LLTGTPLQNK LPELWALLNF
60 70 80 90 100
LLPTIFKSCS TFEQWFNAPF AMTGEKVDLN EEETILIIRR LHKVLRPFLL
110 120 130 140 150
RRLKKEVEAQ LPEKVEYVIK CDMSALQRVL YRHMQAKGVL LTDGSEKDKK
160 170 180 190 200
GKGGTKTLMN TIMQLRKICN HPYMFQHIEE SFSEHLGFTG GIVQGLDLYR
210 220 230 240 250
ASGKFELLDR ILPKLRATNH KVLLFCQMTS LMTIMEDYFA YRGFKYLRLD
260 270 280 290 300
GTTKAEDRGM LLKTFNEPGS EYFIFLLSTR AGGLGLNLQS ADTVIIFDSD
310 320 330 340 350
WNPHQDLQAQ DRAHRIGQQN EVRVLRLCTV NSVEEKILAA AKYKLNVDQK
360 370 380 390 400
VIQAGMFDQK SSSHERRAFL QAILEHEEQD EEEDEVPDDE TVNQMIARHE
410 420 430 440 450
EEFDLFMRMD LDRRREEARN PKRKPRLMEE DELPSWIIKD DAEVERLTCE
460 470 480 490 500
EEEEKMFGRG SRHRKEVDYS DSLTEKQWLK AIEEGTLEEI EEEVRQKKSS
510 520 530 540 550
RKRKRDSDAG SSTPTTSTRS RDKDDESKKQ KKRGRPPAEK LSPNPPNLTK
560 570 580 590 600
KMKKIVDAVI KYKDSSSGRQ LSEVFIQLPS RKELPEYYEL IRKPVDFKKI
610 620 630 640 650
KERIRNHKYR SLNDLEKDVM LLCQNAQTFN LEGSLIYEDS IVLQSVFTSV
660 670 680 690 700
RQKIEKEDDS EGEESEEEEE GEEEGSESES RSVKVKIKLG RKEKAQDRLK
710 720 730
GGRRRPSRGS RAKPVVSDDD SEEEQEEDRS GSGSEED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055168 mRNA Translation: BAG51479.1 |
RefSeqi | NP_001122317.1, NM_001128845.1 NP_001122318.1, NM_001128846.1 NP_001122319.1, NM_001128847.1 NP_001122320.1, NM_001128848.1 |
Genome annotation databases
GeneIDi | 6597 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055168 mRNA Translation: BAG51479.1 |
RefSeqi | NP_001122317.1, NM_001128845.1 NP_001122318.1, NM_001128846.1 NP_001122319.1, NM_001128847.1 NP_001122320.1, NM_001128848.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B3KNW7 |
PRIDEi | B3KNW7 |
Protocols and materials databases
DNASUi | 6597 |
Genome annotation databases
GeneIDi | 6597 |
Organism-specific databases
CTDi | 6597 |
PharmGKBi | PA35950 |
Miscellaneous databases
BioGRID-ORCSi | 6597, 183 hits in 1015 CRISPR screens |
GenomeRNAii | 6597 |
Gene expression databases
Genevisiblei | B3KNW7, HS |
Family and domain databases
Gene3Di | 1.20.920.10, 1 hit 3.40.50.10810, 1 hit |
InterProi | View protein in InterPro IPR030100, BRG1 IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR029295, SnAC IPR038718, SNF2-like_sf IPR000330, SNF2_dom |
PANTHERi | PTHR10799:SF76, PTHR10799:SF76, 1 hit |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF00271, Helicase_C, 1 hit PF14619, SnAC, 1 hit PF00176, SNF2_N, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00297, BROMO, 1 hit SM00490, HELICc, 1 hit SM01314, SnAC, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 1 hit PS50014, BROMODOMAIN_2, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B3KNW7_HUMAN | |
Accessioni | B3KNW7Primary (citable) accession number: B3KNW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | April 7, 2021 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |