UniProtKB - B3KNL2 (B3KNL2_HUMAN)
Protein
RuvB-like helicase
Gene
RUVBL2
Organism
Homo sapiens (Human)
Status
Functioni
Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.UniRule annotation
Catalytic activityi
- EC:3.6.4.12UniRule annotation
GO - Molecular functioni
- 5'-3' DNA helicase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
Keywordsi
Molecular function | HelicaseUniRule annotation, Hydrolase |
Biological process | DNA damage, DNA recombinationUniRule annotationARBA annotation, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RUVBL2Imported ORF Names:hCG_16214Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- Ino80 complex Source: InterPro
- NuA4 histone acetyltransferase complex Source: InterPro
Other locations
- R2TP complex Source: InterPro
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 327 | AAAInterPro annotationAdd BLAST | 293 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 2.40.50.360, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR027417, P-loop_NTPase IPR027238, RuvB-like IPR041048, RuvB-like_C IPR037942, RUVBL2 IPR042487, RUVBL2_DII IPR010339, TIP49_P-loop |
PANTHERi | PTHR11093, PTHR11093, 1 hit PTHR11093:SF2, PTHR11093:SF2, 1 hit |
Pfami | View protein in Pfam PF06068, TIP49, 1 hit PF17856, TIP49_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
B3KNL2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCASHPQASQ GMVGQLAARR AAGVVLEMIR EGKIAGRAVL IAGQPGTGKT
60 70 80 90 100
AIAMGMAQAL GPDTPFTAIA GSEIFSLEMS KTEALTQAFR RSIGVRIKEE
110 120 130 140 150
TEIIEGEVVE IQIDRPATGT GSKVGKLTLK TTEMETIYDL GTKMIESLTK
160 170 180 190 200
DKVQAGDVIT IDKATGKISK LGRSFTRARD YDAMGSQTKF VQCPDGELQK
210 220 230 240 250
RKEVVHTVSL HEIDVINSRT QGFLALFSGD TGEIKSEVRE QINAKVAEWR
260 270 280 290 300
EEGKAEIIPG VLFIDEVHML DIESFSFLNR ALESDMAPVL IMATNRGITR
310 320 330 340 350
IRGTSYQSPH GIPIDLLDRL LIVSTTPYSE KDTKQILRIR CEEEDVEMSE
360 370 380 390 400
DAYTVLTRIG LETSLRYAIQ LITAASLVCR KRKGTEVQVD DIKRVYSLFL
410 420
DESRSTQYMK EYQDAFLFNE LKGETMDTS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027762 mRNA Translation: BAG51374.1 CH471177 Genomic DNA Translation: EAW52429.1 |
RefSeqi | NP_001308119.1, NM_001321190.1 |
Genome annotation databases
GeneIDi | 10856 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027762 mRNA Translation: BAG51374.1 CH471177 Genomic DNA Translation: EAW52429.1 |
RefSeqi | NP_001308119.1, NM_001321190.1 |
3D structure databases
SMRi | B3KNL2 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | B3KNL2 |
PRIDEi | B3KNL2 |
Genome annotation databases
GeneIDi | 10856 |
Organism-specific databases
CTDi | 10856 |
Miscellaneous databases
BioGRID-ORCSi | 10856, 764 hits in 850 CRISPR screens |
ChiTaRSi | RUVBL2, human |
GenomeRNAii | 10856 |
Family and domain databases
Gene3Di | 2.40.50.360, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR027417, P-loop_NTPase IPR027238, RuvB-like IPR041048, RuvB-like_C IPR037942, RUVBL2 IPR042487, RUVBL2_DII IPR010339, TIP49_P-loop |
PANTHERi | PTHR11093, PTHR11093, 1 hit PTHR11093:SF2, PTHR11093:SF2, 1 hit |
Pfami | View protein in Pfam PF06068, TIP49, 1 hit PF17856, TIP49_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B3KNL2_HUMAN | |
Accessioni | B3KNL2Primary (citable) accession number: B3KNL2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | December 2, 2020 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |