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UniProtKB - B3KNK9 (B3KNK9_HUMAN)

Entry version 106 (10 Feb 2021)
Sequence version 1 (02 Sep 2008)
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Protein
Submitted name:

Epididymis luminal protein 46

Gene

HEL46

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Epididymis luminal protein 46Imported
Submitted name:
Golgi phosphoprotein 2, isoform CRA_aImported
Submitted name:
cDNA FLJ14811 fis, clone NT2RP4001975, highly similar to Golgi phosphoprotein 2Imported
Submitted name:
cDNA PSEC0257 fis, clone NT2RP3003642, highly similar to golgi phosphoprotein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEL46Imported
Synonyms:GOLPH2Imported
ORF Names:hCG_29469Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135052.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28811

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		B3KNK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135052, Expressed in prostate gland and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		B3KNK9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		B3KNK9, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		B3KNK9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni178 – 401DisorderedSequence analysisAdd BLAST224

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili39 – 59Sequence analysisAdd BLAST21
Coiled coili67 – 87Sequence analysisAdd BLAST21
Coiled coili110 – 144Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi187 – 206PolarSequence analysisAdd BLAST20
Compositional biasi224 – 242PolarSequence analysisAdd BLAST19
Compositional biasi245 – 283PolyampholyteSequence analysisAdd BLAST39
Compositional biasi314 – 351PolyampholyteSequence analysisAdd BLAST38
Compositional biasi377 – 401PolyampholyteSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLM family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055640_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		QREKRNH

Database of Orthologous Groups

More...OrthoDBi		1073183at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026143, GOLM1
IPR026139, GOLM1/CASC4

The PANTHER Classification System

More...PANTHERi		PTHR15896, PTHR15896, 1 hit
PTHR15896:SF8, PTHR15896:SF8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02084, GOLM1CASC4

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3KNK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE 
        60         70         80         90        100
GRVRRAAAER GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ 
       110        120        130        140        150
DEKAVLVNNI TTGERLIRVL QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER 
       160        170        180        190        200
KFSYDLSQCI NQMKEVKEQC EERIEEVTKK GNEAVASRDL SENNDQRQQL 
       210        220        230        240        250
QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS EVVLDSKRQV 
       260        270        280        290        300
EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP 
       310        320        330        340        350
QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD 
       360        370        380        390        400
YNMDENEAES ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT 

L
Length:401
Mass (Da):45,333
Last modified:September 2, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24C1DC31E47B5B77
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EU794616 mRNA Translation: ACJ13670.1
AK027717 mRNA Translation: BAG51371.1
AK075557 mRNA Translation: BAG52167.1
CH471089 Genomic DNA Translation: EAW62705.1
CH471089 Genomic DNA Translation: EAW62706.1

NCBI Reference Sequences

More...RefSeqi		NP_057632.2, NM_016548.3
NP_808800.1, NM_177937.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51280

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51280

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU794616 mRNA Translation: ACJ13670.1
AK027717 mRNA Translation: BAG51371.1
AK075557 mRNA Translation: BAG52167.1
CH471089 Genomic DNA Translation: EAW62705.1
CH471089 Genomic DNA Translation: EAW62706.1
RefSeqiNP_057632.2, NM_016548.3
NP_808800.1, NM_177937.2

3D structure databases

SMRiB3KNK9
ModBaseiSearch...

Protein-protein interaction databases

IntActiB3KNK9, 2 interactors

Proteomic databases

PRIDEiB3KNK9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2449, 694 antibodies

The DNASU plasmid repository

More...DNASUi		51280

Genome annotation databases

GeneIDi51280
KEGGihsa:51280

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51280
PharmGKBiPA28811
VEuPathDBiHostDB:ENSG00000135052.16

Phylogenomic databases

HOGENOMiCLU_055640_0_0_1
OMAiQREKRNH
OrthoDBi1073183at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51280, 4 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GOLM1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51280

Gene expression databases

BgeeiENSG00000135052, Expressed in prostate gland and 221 other tissues
ExpressionAtlasiB3KNK9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026143, GOLM1
IPR026139, GOLM1/CASC4
PANTHERiPTHR15896, PTHR15896, 1 hit
PTHR15896:SF8, PTHR15896:SF8, 1 hit
PRINTSiPR02084, GOLM1CASC4

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3KNK9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3KNK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 2, 2008
Last sequence update: September 2, 2008
Last modified: February 10, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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