UniProtKB - B3KMS0 (B3KMS0_HUMAN)
Protein
Condensin complex subunit 1
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.UniRule annotation
GO - Biological processi
- cell division Source: UniProtKB-KW
- mitotic chromosome condensation Source: InterPro
Keywordsi
Biological process | Cell cycle, Cell division, DNA condensationUniRule annotationARBA annotation, MitosisUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Condensin complex subunit 1UniRule annotationARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Other locations
- Chromosome ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chromosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
ChromosomeARBA annotation, NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 240 | Cnd1_NInterPro annotationAdd BLAST | 164 | |
Domaini | 1070 – 1230 | Cnd1InterPro annotationAdd BLAST | 161 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 576 – 611 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 1303 – 1401 | DisorderedSequence analysisAdd BLAST | 99 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 450 – 470 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 578 – 601 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1313 – 1339 | PolarSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OrthoDBi | 166920at2759 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR026971, CND1/NCAPD3 IPR032682, Cnd1_C IPR007673, Condensin_cplx_su1 IPR024324, Condensin_cplx_su1_N |
PANTHERi | PTHR14222, PTHR14222, 1 hit PTHR14222:SF2, PTHR14222:SF2, 1 hit |
Pfami | View protein in Pfam PF12717, Cnd1, 1 hit PF12922, Cnd1_N, 1 hit |
PIRSFi | PIRSF017127, Condensin_D2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Complete.
B3KMS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPQMYEFHL PLSPEELLKS GGVNQYVVQE VLSIKHLPPQ LRAFQAAFRA
60 70 80 90 100
QGPLAMLQHF DTIYSILHHF RSIDPGLKED TLEFLIKVVS RHSQELPAIL
110 120 130 140 150
DDTTLSGSDR NAHLNALKMN CYALIRLLES FETMASQTNL VDLDLGGKGK
160 170 180 190 200
KARTKAAHGF DWEEERQPIL QLLTQLLQLD IRHLWNHSII EEEFVSLVTG
210 220 230 240 250
CCYRLLENPT INHQKNRPTR EAITHLLGVA LTRYNHMLSA TVKIIQMLQH
260 270 280 290 300
FEHLAPVLVA AVSLWATDYG MKSIVGEIVR EIGQKCPQEL SRDPSGTKGF
310 320 330 340 350
AAFLTELAER VPAILMSSMR ILLDHLDGEN YMMRNAVLAA MAEMVLQVLS
360 370 380 390 400
GDQLEAAARD TRDQFLDTLQ AHGHDVNSFV RSRVLQLFTR IVQQKALPLT
410 420 430 440 450
RFQAVVALAV GRLADKSVLV CKNAIQLLAS FLANNPFSCK LSDADLAGPL
460 470 480 490 500
QKETQKLQEM RAQRRTAAAS AVLDPEEEWE AMLPELKSTL QQLLQLPQGE
510 520 530 540 550
EEIPEQIANT ETTEDVKGRI YQLLAKASYK KAIILTREAT GHFQESEPFS
560 570 580 590 600
HIDPEESEET RLLNILGLIF KGPAASTQEK NPRESTGNMV TGQTVCKNKP
610 620 630 640 650
NMSDPEESRG NDELVKQEML VQYLQDAYSF SRKITEAIGI ISKMMYENTT
660 670 680 690 700
TVVQEVIEFF VMVFQFGVPQ ALFGVRRMLP LIWSKEPGVR EAVLNAYRQL
710 720 730 740 750
YLNPKGDSAR AKAQALIQNL SLLLVDASVG TIQCLEEILC EFVQKDELKP
760 770 780 790 800
AVTQLLWERA TEKVACCPLE RCSSVMLLGM MARGKPEIVG SNLDTLVSIG
810 820 830 840 850
LDEKFPQDYR LAQQVCHAIA NISDRRKTSL GKRHPPFRLP QEHRLFERLR
860 870 880 890 900
ETVTKGFVHP DPLWIPFKEV AVTLIYQLAE GPEVICAQIL QGCAKQALEK
910 920 930 940 950
LEEKRTSQED PKESPAMLPT FLLMNLLSLA GDVALQQLVH LEQAVGGELC
960 970 980 990 1000
RRRVLREELE HKTKDPKEKN TSSETTMEEE LGLVGATADD TEAELIRGIC
1010 1020 1030 1040 1050
EMELLDGKQT LAAFVPLLLK VCNNPGLYSN PDLSAAASLA LGKFCMISAT
1060 1070 1080 1090 1100
FCDSQLRLLF TMLEKSPLPI VRSNLMVATG DLAIRFPNLV DPWTPHLYAR
1110 1120 1130 1140 1150
LRDPAQQVRK TAGLVMTHLI LKDMVKVKGQ VSEMAVLLID PEPQIAALAK
1160 1170 1180 1190 1200
NFFNELSHKG NAIYNLLPDI ISRLSDPELG VEEEPFHTIM KQLLSYITKD
1210 1220 1230 1240 1250
KQTESLVEKL CQRFRTSRTE RQQRDLAYCV SQLPLTERGL RKMLDNFDCF
1260 1270 1280 1290 1300
GDKLSDESIF SAFLSVVGKL RRGAKPEGKA IIDEFEQKLR ACHTRGLDGI
1310 1320 1330 1340 1350
KELEIGQAGS QRAPSAKKPS TGSRYQPLAS TASDNDFVTP EPRRTTRRHP
1360 1370 1380 1390 1400
NTQQRASKKK PKVVFSSDES SEEDLSAEMT EDETPKKTTP ILRASARRHR
S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022511 mRNA Translation: BAG51082.1 |
RefSeqi | NP_055680.3, NM_014865.3 |
Genome annotation databases
GeneIDi | 9918 |
KEGGi | hsa:9918 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022511 mRNA Translation: BAG51082.1 |
RefSeqi | NP_055680.3, NM_014865.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B3KMS0, 2 interactors |
Proteomic databases
PeptideAtlasi | B3KMS0 |
PRIDEi | B3KMS0 |
Genome annotation databases
GeneIDi | 9918 |
KEGGi | hsa:9918 |
Organism-specific databases
CTDi | 9918 |
PharmGKBi | PA162397021 |
Phylogenomic databases
OrthoDBi | 166920at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9918, 591 hits in 850 CRISPR screens |
GenomeRNAii | 9918 |
Gene expression databases
Genevisiblei | B3KMS0, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR026971, CND1/NCAPD3 IPR032682, Cnd1_C IPR007673, Condensin_cplx_su1 IPR024324, Condensin_cplx_su1_N |
PANTHERi | PTHR14222, PTHR14222, 1 hit PTHR14222:SF2, PTHR14222:SF2, 1 hit |
Pfami | View protein in Pfam PF12717, Cnd1, 1 hit PF12922, Cnd1_N, 1 hit |
PIRSFi | PIRSF017127, Condensin_D2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B3KMS0_HUMAN | |
Accessioni | B3KMS0Primary (citable) accession number: B3KMS0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 2, 2008 |
Last sequence update: | September 2, 2008 | |
Last modified: | December 2, 2020 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |