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Entry version 91 (31 Jul 2019)
Sequence version 1 (22 Jul 2008)
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Protein
Submitted name:

HECT ubiquitin protein ligase family protein KAK

Gene

KAK

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation EC:2.3.2.26

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1761Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigaseImported, TransferaseSAAS annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HECT ubiquitin protein ligase family protein KAKImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KAKImported
Synonyms:KAKTUSImported, UBIQUITIN-PROTEIN LIGASE 3Imported, UBIQUITIN_PROTEIN LIGASEImported, UPL3Imported
Ordered Locus Names:At4g38600Imported, At4g38610Imported
ORF Names:F20M13.160Imported, F20M13_160Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G38600

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B3H700

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B3H700 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1404 – 1794HECTInterPro annotationAdd BLAST391

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 84DisorderedSequence analysisAdd BLAST84
Regioni587 – 638DisorderedSequence analysisAdd BLAST52
Regioni897 – 1028DisorderedSequence analysisAdd BLAST132
Regioni1043 – 1066DisorderedSequence analysisAdd BLAST24
Regioni1101 – 1120DisorderedSequence analysisAdd BLAST20
Regioni1189 – 1216DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21PolarSequence analysisAdd BLAST21
Compositional biasi22 – 51PolyampholyteSequence analysisAdd BLAST30
Compositional biasi616 – 638PolarSequence analysisAdd BLAST23
Compositional biasi912 – 944PolarSequence analysisAdd BLAST33
Compositional biasi993 – 1022AcidicSequence analysisAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0168 Eukaryota
KOG0170 Eukaryota
COG5021 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000238707

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B3H700

Database of Orthologous Groups

More...
OrthoDBi
34110at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B3H700

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078 HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00632 HECT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 3 hits
SM00119 HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B3H700-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSTDSSGF RRGGRGNRGN NNDNSDKGKE KEHDVRIRER ERERDRAREQ
60 70 80 90 100
LNMDAAAAAA RSADEDDDND SEDGNGGFMH PNMSSASSAL QGLLRKLGAG
110 120 130 140 150
LDDLLPSSGI GSASSSHLNG RMKKILSGLR AEGEEGKQVE ALTQLCEMLS
160 170 180 190 200
IGTEDSLSTF SVDSFVPVLV GLLNHESNPD IMLLAARALT HLCDVLPSSC
210 220 230 240 250
AAVVHYGAVS CLVARLLTIE YMDLAEQSLQ ALKKISQEHP TACLRAGALM
260 270 280 290 300
AVLSYLDFFS TGVQRVALST AANMCKKLPS DASDYVMEAV PLLTNLLQYH
310 320 330 340 350
DSKVLEYASI CLTRIAEAFA PYPEKLDELC NHGLVTQAAS LISTSNSGGG
360 370 380 390 400
QASLSVSTYT GLIRLLSTCA SGSPLGFRTL LLLGISSILK DILLGSGVSA
410 420 430 440 450
NASVSPALSR PADQIYEIVN LANELLPPLP EGVISLPTST NALVKGSCQK
460 470 480 490 500
KSSPSTSGKQ EDILKISPRE KLLGDQPELL QQFGLDLLPV LVQIYGSSVN
510 520 530 540 550
GTIRHKCLSV IGKLMYFSSS EMIQSLIGDT NISSFLAGVL AWKDPQVLVP
560 570 580 590 600
ALQVAEILME KLPETFSKVF VREGVVHAVD QLVLVGKPSH ASPTDKDNDC
610 620 630 640 650
VPGSARSRRY RRRSSNANSD GNQSEEPKNP ASLTIGANHN SLDTPTASFM
660 670 680 690 700
LRETVSSCAK AFKDKYFPSD GGDVDVGVTD DLLHLKNLCT KLTAGIDDHK
710 720 730 740 750
VKGKGKSKAS GPFLGDFSAS KEEYLIGVIS EILGEISKGD GVSTFEFIGS
760 770 780 790 800
GVVAALLNYF SCGYFSKEKI SELNLPKLRQ EGLRRFKAFL EVALPFDGNE
810 820 830 840 850
GKVPPMTVLI QKLQNALSSL ERFPVVLSHP SRSLSGSARL SSGLSALAHP
860 870 880 890 900
LKLRLCRASG EKTLRDYSSN IVLIDPLASL AAVEEFLWPR VQRSESALKP
910 920 930 940 950
AAPIGNTEPG TLPSGAGVSS PSSSTPASTT RRHSSRSRSA INIGDTSKKD
960 970 980 990 1000
PVHEKGTSSS KGKGKGVMKP AQADKGPQTR SNAQKRADEE LEISPVDIDD
1010 1020 1030 1040 1050
ALVIEEDDIS DDEDDDNEDV LDDSLPMCTP DKVHDVKLAD SVDDDGLATS
1060 1070 1080 1090 1100
GRQMNPASGG TSGAAAARAS DSIDTGIGNS YGSRGALSFA AAAMAGLGAA
1110 1120 1130 1140 1150
SGRGIRGSRD LHGRTLNRSS DEPSKLIFTA AGKQLSRHLT IYQAVQRQLM
1160 1170 1180 1190 1200
LDEDDDDRFG GSDLVSSDGS RFNDIYTIMY QRPDSQVNRL SVGGASSTTP
1210 1220 1230 1240 1250
SKSTKSATTN SSVESQSHRA SLLDSILQGE LPCDLEKSNS TYNVLALLRV
1260 1270 1280 1290 1300
LEGLNQLCPR LRAQTLSDRF AEGKITSLDD LSTTAAKVPL DEFVNSKLTP
1310 1320 1330 1340 1350
KLARQIQDAL ALCSGSLPSW CYQLTRACPF LFPFQTRRQY FYSTAFGLSR
1360 1370 1380 1390 1400
ALNRLQQQQG ADGSGSTNER EMRIGRLQRQ KVRVSRNRIL DSAAKVMEMY
1410 1420 1430 1440 1450
SSQKAVLEVE YFGEVGTGLG PTLEFYTLLS HDLQKASLGM WRSSSGDKVS
1460 1470 1480 1490 1500
MQIGRDEIED GKPSAANRDI VLAPLGLFPR PWPSTADISE GGQFHKVIEY
1510 1520 1530 1540 1550
FRLLGRVMAK ALQDGRLLDV PLSTAFYKLI LGQELDLHDI VLFDAELGKT
1560 1570 1580 1590 1600
LQELRVVVAR KHYLEGVGGD NSSTISDLCL RGCRIEDLSL EFTLPGYPEY
1610 1620 1630 1640 1650
ILRSGDEIVD ITNLEEYISL VVDATVKRGV TRQIEAFRSG FNQVFDITSL
1660 1670 1680 1690 1700
QIFTPSELDY LLCGRRELWE VETLAEHIKF DHGYNAKSPA IINIMGELTA
1710 1720 1730 1740 1750
DQQRAFCQFV TGAPRLPPGG LAVLNPKLTI VRKHSSTSSA AANGAGASET
1760 1770 1780 1790
ADDDLPSVMT CANYLKLPPY STKEIMYKKL LYAINEGQGS FDLS
Length:1,794
Mass (Da):193,454
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8155AF11725B53C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6WWW4UPL3_ARATH
E3 ubiquitin-protein ligase UPL3
UPL3 KAK, At4g38600/At4g38610, F20M13.160/F20M13.170
1,888Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP002687 Genomic DNA Translation: AEE86953.1

NCBI Reference Sequences

More...
RefSeqi
NP_195572.2, NM_120021.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G38600.2; AT4G38600.2; AT4G38600

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
830017

Gramene; a comparative resource for plants

More...
Gramenei
AT4G38600.2; AT4G38600.2; AT4G38600

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002687 Genomic DNA Translation: AEE86953.1
RefSeqiNP_195572.2, NM_120021.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiB3H700

Genome annotation databases

EnsemblPlantsiAT4G38600.2; AT4G38600.2; AT4G38600
GeneIDi830017
GrameneiAT4G38600.2; AT4G38600.2; AT4G38600

Organism-specific databases

AraportiAT4G38600

Phylogenomic databases

eggNOGiKOG0168 Eukaryota
KOG0170 Eukaryota
COG5021 LUCA
HOGENOMiHOG000238707
InParanoidiB3H700
OrthoDBi34110at2759
PhylomeDBiB3H700

Gene expression databases

ExpressionAtlasiB3H700 baseline and differential

Family and domain databases

CDDicd00078 HECTc, 1 hit
Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
PfamiView protein in Pfam
PF00632 HECT, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 3 hits
SM00119 HECTc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3H700_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3H700
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 31, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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