UniProtKB - B3GN61 (B3GN61_HUMAN)
Protein
Submitted name:
Truncated E-cadherin
Gene
CDH1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Ligand | CalciumPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Truncated E-cadherinImported |
Gene namesi | Name:CDH1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 709 – 731 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5002788831 | 23 – 758 | Sequence analysisAdd BLAST | 736 |
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotation, GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | B3GN61 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 180 – 262 | CadherinInterPro annotationAdd BLAST | 83 | |
Domaini | 263 – 375 | CadherinInterPro annotationAdd BLAST | 113 | |
Domaini | 376 – 486 | CadherinInterPro annotationAdd BLAST | 111 | |
Domaini | 487 – 595 | CadherinInterPro annotationAdd BLAST | 109 | |
Domaini | 594 – 702 | CadherinInterPro annotationAdd BLAST | 109 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OrthoDBi | 182239at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR014868, Cadherin_pro_dom IPR030049, CDH1 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF319, PTHR24027:SF319, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 5 hits |
i Sequence
Sequence statusi: Complete.
B3GN61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR
60 70 80 90 100
VLGRVNFEDC TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV
110 120 130 140 150
YAWDSTYRKF STKVTLNTVG HHHRPPPHQA SVSGIQAELL TFPNSSPGLR
160 170 180 190 200
RQKRDWVIPP ISCPENEKGP FPKNLVQIKS NKDKEGKVFY SITGQGADTP
210 220 230 240 250
PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN AVEDPMEILI
260 270 280 290 300
TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI
310 320 330 340 350
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL
360 370 380 390 400
QGEGLSTTAT AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD
410 420 430 440 450
ADAPNTPAWE AVYTILNDDG GQFVVTTNPV NNDGILKTAK GLDFEAKQQY
460 470 480 490 500
ILHVAVTNVV PFEVSLTTST ATVTVDVLDV NEAPIFVPPE KRVEVSEDFG
510 520 530 540 550
VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG AISTRAELDR
560 570 580 590 600
EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI
610 620 630 640 650
FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI
660 670 680 690 700
ILKPKMALEV GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP
710 720 730 740 750
VEAGLQIPAI LGILGGILAL LILILLLLLF LRRRAVVKEP LLPPEDDTRD
NVYYYDEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU709494 mRNA Translation: ACD87624.1 |
RefSeqi | NP_001304113.1, NM_001317184.1 NP_001304114.1, NM_001317185.1 NP_001304115.1, NM_001317186.1 NP_004351.1, NM_004360.4 |
Genome annotation databases
GeneIDi | 999 |
KEGGi | hsa:999 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU709494 mRNA Translation: ACD87624.1 |
RefSeqi | NP_001304113.1, NM_001317184.1 NP_001304114.1, NM_001317185.1 NP_001304115.1, NM_001317186.1 NP_004351.1, NM_004360.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B3GN61 |
Genome annotation databases
GeneIDi | 999 |
KEGGi | hsa:999 |
Organism-specific databases
CTDi | 999 |
Phylogenomic databases
OrthoDBi | 182239at2759 |
Miscellaneous databases
BioGRID-ORCSi | 999, 35 hits in 881 CRISPR screens |
ChiTaRSi | CDH1, human |
GenomeRNAii | 999 |
Family and domain databases
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR014868, Cadherin_pro_dom IPR030049, CDH1 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF319, PTHR24027:SF319, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B3GN61_HUMAN | |
Accessioni | B3GN61Primary (citable) accession number: B3GN61 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 22, 2008 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 10, 2021 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |