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Entry version 83 (02 Dec 2020)
Sequence version 1 (22 Jul 2008)
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Protein

G-protein coupled estrogen receptor 1

Gene

gper1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. Specifically induces apoptosis and reduces proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes.3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Binds 17-beta-estradiol (E2) in plasma membranes with high affinity and displays rapid kinetics of association and dissociation.1 Publication

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
      Biological processApoptosis, Cell cycle, Differentiation, Neurogenesis

      Enzyme and pathway databases

      Reactome - a knowledgebase of biological pathways and processes

      More...
      Reactomei
      R-DRE-375276, Peptide ligand-binding receptors
      R-DRE-418594, G alpha (i) signalling events

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      G-protein coupled estrogen receptor 1
      Alternative name(s):
      G protein-coupled estrogen receptor 1
      G-protein coupled receptor 30
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:gper1
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

      Organism-specific databases

      Zebrafish Information Network genome database

      More...
      ZFINi
      ZDB-GENE-090311-1, gper1

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

      Topology

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
      Topological domaini62 – 81CytoplasmicSequence analysisAdd BLAST20
      Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
      Topological domaini103 – 112ExtracellularSequence analysis10
      Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
      Topological domaini134 – 160CytoplasmicSequence analysisAdd BLAST27
      Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
      Topological domaini182 – 202ExtracellularSequence analysisAdd BLAST21
      Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
      Topological domaini224 – 245CytoplasmicSequence analysisAdd BLAST22
      Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
      Topological domaini267 – 292ExtracellularSequence analysisAdd BLAST26
      Transmembranei293 – 313Helical; Name=7Sequence analysisAdd BLAST21
      Topological domaini314 – 353CytoplasmicSequence analysisAdd BLAST40

      Keywords - Cellular componenti

      Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Nucleus, Postsynaptic cell membrane, Synapse

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

      Morpholino knockdown of the protein leads to growth retardation and developmental deformity.1 Publication

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004245441 – 353G-protein coupled estrogen receptor 1Add BLAST353

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi115 ↔ 192PROSITE-ProRule annotation

      Keywords - PTMi

      Disulfide bond

      Proteomic databases

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      B3G515

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

      Expressed in brain regions that are known to control reproduction and sex behavior. Expressed in ovary, muscle and intestine. Expressed in early germ cells of the testis, including the spermatogonia, spermatocytes, and somatic cells such as Sertoli cells.1 Publication

      <p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

      Expressed throughout early embryonic development from 0 hours post-fertilization (hpf) to 72 hpf. Expressed in blastomeres at 4 hpf. Expressed in the central nervous system at 18 hpf. Expressed in head including the anterior diencephalon, midbrain and hindbrain at 24 hpf. Expressed in trigeminal ganglia as well as in the heart, pancreas and intestinal bulb between 36 and 72 hpf (at protein level).1 Publication

      Gene expression databases

      Bgee dataBase for Gene Expression Evolution

      More...
      Bgeei
      ENSDARG00000074661, Expressed in heart and 14 other tissues

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Homodimer. Heterodimer (By similarity).

      By similarity

      Protein-protein interaction databases

      STRING: functional protein association networks

      More...
      STRINGi
      7955.ENSDARP00000070486

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

      Keywords - Domaini

      Transmembrane, Transmembrane helix

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      ENOG502QU56, Eukaryota

      Ensembl GeneTree

      More...
      GeneTreei
      ENSGT00940000154307

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      CLU_009579_8_3_1

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      B3G515

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      VHLQHTE

      Database of Orthologous Groups

      More...
      OrthoDBi
      736624at2759

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      B3G515

      TreeFam database of animal gene trees

      More...
      TreeFami
      TF333506

      Family and domain databases

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR000276, GPCR_Rhodpsn
      IPR017452, GPCR_Rhodpsn_7TM

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF00001, 7tm_1, 1 hit

      Protein Motif fingerprint database; a protein domain database

      More...
      PRINTSi
      PR00237, GPCRRHODOPSN

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
      PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      B3G515-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MEEQTTNVIQ IYVNGTEQFN ASFDFNITDV KESTDTYEFY IIGLFLSCLY
      60 70 80 90 100
      TIFLFPIGFI GNILILVVNL NHRERMTIPD LYFVNLAVAD LILVADSLIE
      110 120 130 140 150
      VFNLNEKYYD YAVLCTFMSL FLQVNMYSSI FFLTWMSFDR YVALTSSMSS
      160 170 180 190 200
      SPLRTMQHAK LSCSLIWMAS ILATLLPFTI VQTQHTGEVH FCFANVFEIQ
      210 220 230 240 250
      WLEVTIGFLI PFSIIGLCYS LIVRTLMRAQ KHKGLWPRRQ KALRMIVVVV
      260 270 280 290 300
      LVFFICWLPE NVFISIQLLQ GTADPSKRTD TTLWHDYPLT GHIVNLAAFS
      310 320 330 340 350
      NSCLNPIIYS FLGETFRDKL RLFIKRKASW SVVYRFCNHT LDLQIPVRSE

      SEV
      Length:353
      Mass (Da):40,859
      Last modified:July 22, 2008 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB88913B13954D4B2
      GO

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      EU652771 mRNA Translation: ACD88749.1
      CR382361 Genomic DNA No translation available.

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_001122195.1, NM_001128723.1
      XP_009298009.1, XM_009299734.2

      Genome annotation databases

      Ensembl eukaryotic genome annotation project

      More...
      Ensembli
      ENSDART00000076007; ENSDARP00000070486; ENSDARG00000074661
      ENSDART00000189772; ENSDARP00000156576; ENSDARG00000074661

      Database of genes from NCBI RefSeq genomes

      More...
      GeneIDi
      565271

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      dre:565271

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      EU652771 mRNA Translation: ACD88749.1
      CR382361 Genomic DNA No translation available.
      RefSeqiNP_001122195.1, NM_001128723.1
      XP_009298009.1, XM_009299734.2

      3D structure databases

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      SWISS-MODEL Interactive Workspace

      More...
      SWISS-MODEL-Workspacei
      Submit a new modelling project...

      Protein-protein interaction databases

      STRINGi7955.ENSDARP00000070486

      Protein family/group databases

      Information system for G protein-coupled receptors (GPCRs)

      More...
      GPCRDBi
      Search...

      Proteomic databases

      PaxDbiB3G515

      Genome annotation databases

      EnsembliENSDART00000076007; ENSDARP00000070486; ENSDARG00000074661
      ENSDART00000189772; ENSDARP00000156576; ENSDARG00000074661
      GeneIDi565271
      KEGGidre:565271

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      2852
      ZFINiZDB-GENE-090311-1, gper1

      Phylogenomic databases

      eggNOGiENOG502QU56, Eukaryota
      GeneTreeiENSGT00940000154307
      HOGENOMiCLU_009579_8_3_1
      InParanoidiB3G515
      OMAiVHLQHTE
      OrthoDBi736624at2759
      PhylomeDBiB3G515
      TreeFamiTF333506

      Enzyme and pathway databases

      ReactomeiR-DRE-375276, Peptide ligand-binding receptors
      R-DRE-418594, G alpha (i) signalling events

      Miscellaneous databases

      Protein Ontology

      More...
      PROi
      PR:B3G515

      Gene expression databases

      BgeeiENSDARG00000074661, Expressed in heart and 14 other tissues

      Family and domain databases

      InterProiView protein in InterPro
      IPR000276, GPCR_Rhodpsn
      IPR017452, GPCR_Rhodpsn_7TM
      PfamiView protein in Pfam
      PF00001, 7tm_1, 1 hit
      PRINTSiPR00237, GPCRRHODOPSN
      PROSITEiView protein in PROSITE
      PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
      PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPER1_DANRE
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3G515
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2013
      Last sequence update: July 22, 2008
      Last modified: December 2, 2020
      This is version 83 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Reference proteome

      Documents

      1. SIMILARITY comments
        Index of protein domains and families
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