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Entry version 47 (12 Aug 2020)
Sequence version 1 (22 Jul 2008)
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Protein

Succinate--CoA ligase [ADP-forming] subunit alpha

Gene

SCSa

Organism
Blastocystis sp. subtype 1 (strain ATCC 50177 / NandII)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 133 min(-1) with ATP as substrate.1 Publication

      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

      This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation1 Publication
      Proteins known to be involved in this subpathway in this organism are:
      1. Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (AV274_4385), Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (AV274_6110), Succinate--CoA ligase [ADP-forming] subunit beta (SCSb), Succinate--CoA ligase [ADP-forming] subunit alpha (SCSa), Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial (AV274_5644)
      This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
      View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei64Coenzyme AUniRule annotation1
      Binding sitei181Substrate; shared with subunit betaUniRule annotation1
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei271Tele-phosphohistidine intermediateUniRule annotation1

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionLigase
      Biological processTricarboxylic acid cycle
      LigandNucleotide-binding

      Enzyme and pathway databases

      UniPathway: a resource for the exploration and annotation of metabolic pathways

      More...
      UniPathwayi
      UPA00223;UER00999

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Succinate--CoA ligase [ADP-forming] subunit alpha1 Publication (EC:6.2.1.5UniRule annotation1 Publication)
      Alternative name(s):
      Succinyl-CoA synthetase subunit alpha1 PublicationUniRule annotation
      Short name:
      SCS-alphaUniRule annotation
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:SCSa
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBlastocystis sp. subtype 1 (strain ATCC 50177 / NandII)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri478820 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarStramenopilesBigyraOpalozoaOpalinataBlastocystidaeBlastocystis
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000078348 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      GO - Cellular componenti

      Keywords - Cellular componenti

      Hydrogenosome

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 18HydrogenosomeSequence analysisAdd BLAST18
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043859419 – 318Succinate--CoA ligase [ADP-forming] subunit alphaAdd BLAST300

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Heterodimer of an alpha and a beta subunit.

      UniRule annotation

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      B3FHT4

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      Region

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 41Coenzyme A bindingUniRule annotation4
      Regioni117 – 119Coenzyme A bindingUniRule annotation3

      <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

      Keywords - Domaini

      Transit peptide

      Phylogenomic databases

      Database of Orthologous Groups

      More...
      OrthoDBi
      1247548at2759

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      3.40.50.261, 1 hit

      HAMAP database of protein families

      More...
      HAMAPi
      MF_01988, Succ_CoA_alpha, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR017440, Cit_synth/succinyl-CoA_lig_AS
      IPR033847, Citrt_syn/SCS-alpha_CS
      IPR003781, CoA-bd
      IPR005810, CoA_lig_alpha
      IPR005811, CoA_ligase
      IPR036291, NAD(P)-bd_dom_sf
      IPR016102, Succinyl-CoA_synth-like

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF02629, CoA_binding, 1 hit
      PF00549, Ligase_CoA, 1 hit

      PIRSF; a whole-protein classification database

      More...
      PIRSFi
      PIRSF001553, SucCS_alpha, 1 hit

      Simple Modular Architecture Research Tool; a protein domain database

      More...
      SMARTi
      View protein in SMART
      SM00881, CoA_binding, 1 hit

      Superfamily database of structural and functional annotation

      More...
      SUPFAMi
      SSF51735, SSF51735, 1 hit
      SSF52210, SSF52210, 1 hit

      TIGRFAMs; a protein family database

      More...
      TIGRFAMsi
      TIGR01019, sucCoAalpha, 1 hit

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS01216, SUCCINYL_COA_LIG_1, 1 hit
      PS00399, SUCCINYL_COA_LIG_2, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

      B3FHT4-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MLSRVSQVSR VGFSLARASS TARVWVDKNT RVIGQGITGK NGTFHTQQAI
      60 70 80 90 100
      EYGTKMVGGV NPKKAGTTHL GLPIFASVEE AKKATNADAT VIYVPPSGAA
      110 120 130 140 150
      GAILEAVAAE IPLIVCITEG IPQHDMLRVK DIMKSQNKSR LIGPNCPGII
      160 170 180 190 200
      KPEECKIGIM PGYIHKKGKI GIVSRSGTLT YEAVHQTTMY GLGQSTVVGI
      210 220 230 240 250
      GGDPFNGTNF IDCLERFTND PQTEGIVMIG EIGGTAEEDA AEWLKQYGNP
      260 270 280 290 300
      NKPVVSFIAG RTAPPGRRMG HAGAIISGGK GTAKAKMEAL TSAGVKVVET
      310
      PAMIGEAMFN MMKAAGKA
      Length:318
      Mass (Da):33,380
      Last modified:July 22, 2008 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BAC52317C9237E1
      GO

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      EU076378 mRNA Translation: ABY62723.1
      EU090061 Genomic DNA Translation: ABW76150.1
      LXWW01000228 Genomic DNA Translation: OAO14631.1

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      EU076378 mRNA Translation: ABY62723.1
      EU090061 Genomic DNA Translation: ABW76150.1
      LXWW01000228 Genomic DNA Translation: OAO14631.1

      3D structure databases

      SMRiB3FHT4
      ModBaseiSearch...

      Phylogenomic databases

      OrthoDBi1247548at2759

      Enzyme and pathway databases

      UniPathwayiUPA00223;UER00999

      Family and domain databases

      Gene3Di3.40.50.261, 1 hit
      HAMAPiMF_01988, Succ_CoA_alpha, 1 hit
      InterProiView protein in InterPro
      IPR017440, Cit_synth/succinyl-CoA_lig_AS
      IPR033847, Citrt_syn/SCS-alpha_CS
      IPR003781, CoA-bd
      IPR005810, CoA_lig_alpha
      IPR005811, CoA_ligase
      IPR036291, NAD(P)-bd_dom_sf
      IPR016102, Succinyl-CoA_synth-like
      PfamiView protein in Pfam
      PF02629, CoA_binding, 1 hit
      PF00549, Ligase_CoA, 1 hit
      PIRSFiPIRSF001553, SucCS_alpha, 1 hit
      SMARTiView protein in SMART
      SM00881, CoA_binding, 1 hit
      SUPFAMiSSF51735, SSF51735, 1 hit
      SSF52210, SSF52210, 1 hit
      TIGRFAMsiTIGR01019, sucCoAalpha, 1 hit
      PROSITEiView protein in PROSITE
      PS01216, SUCCINYL_COA_LIG_1, 1 hit
      PS00399, SUCCINYL_COA_LIG_2, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUCA_BLAHN
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3FHT4
      Secondary accession number(s): B3FHN9
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
      Last sequence update: July 22, 2008
      Last modified: August 12, 2020
      This is version 47 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Reference proteome

      Documents

      1. PATHWAY comments
        Index of metabolic and biosynthesis pathways
      2. SIMILARITY comments
        Index of protein domains and families
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